T1D发病中的双刃剑——iNKT细胞

doi:10.3969/j.issn.1674-490X.2016.04.010

医学研究与教育 ›› 2016, Vol. 33 ›› Issue (4): 47-51.DOI: 10.3969/j.issn.1674-490X.2016.04.010

T1D发病中的双刃剑——iNKT细胞

刘绍川,娄永富,胡鸿鹏,杨飞,孟明

河北大学医学院, 河北保定 071000

收稿日期:2016-03-22 出版日期:2016-08-25 发布日期:2016-08-25
通讯作者: 孟明(1964—),女,辽宁义县人,教授,博士,硕士生导师,主要从事自身免疫疾病及免疫药理学研究。E-mail: mengming127@163.com
作者简介:刘绍川(1993—),男,土家族,湖南慈利人。
基金资助:
国家自然科学基金资助项目(81373197);河北省自然科学基金(H2015201131);国家级大学生创新项目基金(201510075030);河北大学研究生创新资助项目(X2016090)

The double-edged sword in the pathogenesis of T1D—iNKT cells

LIU Shaochuan,LOU Yongfu,HU Hongpeng,YANG Fei,MENG Ming

Medical College of Hebei University, Baoding 071000, China

Received:2016-03-22 Online:2016-08-25 Published:2016-08-25

摘要/Abstract

摘要： 1型糖尿病(type 1 diabetes,T1D)是一种由遗传因素、环境因素和免疫调节因素共同参与的自身免疫性疾病。由于免疫系统的功能紊乱和调节异常,胰岛β细胞受损,导致胰岛素缺乏,糖代谢紊乱。恒定自然杀伤T(invariant nature killer T,iNKT)细胞是一种同时参与适应性免疫和固有免疫应答的特殊T细胞亚群。近年来发现iNKT细胞与T1D的发病密切相关,虽然有关报道众多但结论不一。旨在对这一领域的最新研究进展进行综述。

关键词: 1型糖尿病, 恒定自然杀伤T细胞, IL-17

Abstract: Type 1 diabetes(Type 1 diabetes,T1D)is a disorder caused by immune,genetic and environmental factors.Due to the dysfunction of the immune system and regulation of abnormal,impaired islet beta cells,leading to the lack of insulin,glucose metabolism disorders.Invariant nature killer T(iNKT)cells are a kind of special T cell subsets in adaptive immunity and innate immunity.In recent years iNKT cells is closely related to the pathogenesis of T1D,but many reports disagree,this review aims to elaborate the research progress in this field.

Key words: Type 1 diabetes, invariant nature killer T, IL-17

中图分类号:

刘绍川,娄永富,胡鸿鹏,杨飞,孟明. T1D发病中的双刃剑——iNKT细胞[J]. 医学研究与教育, 2016, 33(4): 47-51.

LIU Shaochuan,LOU Yongfu,HU Hongpeng,YANG Fei,MENG Ming. The double-edged sword in the pathogenesis of T1D—iNKT cells[J]. Medical Reserch and Education, 2016, 33(4): 47-51.

参考文献

[1] PHILLIPS J M,PARISH N M,BLAND C,et al.Type 1 diabetes development requires both CD4 + and CD8 + T cells and can be reversed by non-depleting antibodies targeting both cell populations[J].Rev Diabet Stud,2009,6(2): 97-103.DOI: 10.1900/RDS.2009.6.97.
[2] SHAMIN L,CLAUDINE J,CHANTAL B,et al.Potential Role of IL-17-producing iNKT cells in type 1 diabetes [J].PLoS One,2014,9(4): e96151.DOI: 10.1371/journal.pone.0096151.
[3] DAVID N,NORA A,MATTNER J.Mechanisms of innate lymphoid cell and natural killer T cell activation during mucosal inflammation[J].J Immunol Res,2014,2014: 546596.DOI: 10.1155/2014/546596.
[4] BRENNAN P J,BRIGL M,BRENNER M B.Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions [J].Nat Rev Immunol,2013,13(2):101-117.DOI: 10.1038/nri3369.
[5] GAPIN L.Development of invariant natural killer T cells [J].Curr Opin Immunol,2016,39:68-74.DOI:10.1016/j.coi.2016.01.001.
[6] AGUIAR C F,NAFFAH-DE-SOUZA C,CASTOLDI A,et al.Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury [J].Mol Med,2015,21:553-562.DOI: 10.2119/molmed.2014.00090.
[7] FICHTNER A S,PALETTA D,STARICK L,et al.Function and expression of CD1d and invariant natural killer T-cell receptor in the cotton rat(Sigmodon hispidus)[J].Immunology,2015,146(4):618-629.DOI: 10.1111/imm.12532.
[8] TSAIH S W,PRESA M,KHAJA S,et al.A locus on mouse Chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells [J].Genes Immun,2015,16(3):221-230.DOI: 10.1038/gene.2014.81.
[9] BERGA-BOLAOS R,SHARMA A,STEINKE F C,et al.β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation [J].BMC Immunol,2015,16(1):62.DOI: 10.1186/s12865-015-0121-0.
[10] WINGENDER G,SAG D,KRONENBERG M,et al.NKT10 cells: a novel iNKT cell subset [J].Oncotarget,2015,6(29):26552-26553.DOI: 10.18632/oncotarget.5270.
[11] HU T,WANG H,SIMMONS A,et al.Increased level of E protein activity during invariant NKT development promotes differentiation of invariant NKT2 and invariant NKT17 subsets [J].J Immunol,2013,191(10):5065-5073.DOI: 10.4049/jimmunol.1301546.
[12] SIMONI Y,GAUTRON A S,BEAUDOIN L,et al.NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes [J].Eur J Immunol,2011,41(12):3574-3585.DOI: 10.1002/eji.201141751.
[13] CHEN Y G,CHOISY-ROSSI C M,HOLL T M,et al.Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes [J].J Immunol,2005,174: 1196-1204.DOI: 10.4049/jimmunol.174.3.1196.
[14] JAAKKOLA,JALKANEN S,HANMINEN A,et al.Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice [J].Eur J Immunol,2003,33:3255-3264.DOI:10.1002/eji.200324405.
[15] CHEN Y G,TSAIH S W,SERREZE D V,et al.Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type [J].Genes Immun,2012,13(2):164-174.DOI: 10.1038/gene.2011.68.
[16] SIMONI Y,DIANA J,GHAZARIAN L,et al.Therapeutic manipulation of natural killer(NK)T cells in autoimmunity: are we close to reality? [J].Clin Exp Immunol,2013,171(1): 8-19.DOI: 10.1111/j.1365-2249.2012.04625.x.
[17] DALAM L,Mi Q S,HUSSAIN S,et al.Protection from type 1 diabetes by invariant NK T cells requires the activity of CD4+CD25+ regulatory T cells [J].J Immunol,2006,177(6):3695-3704.DOI: 10.4049/jimmunol.177.6.3695.
[18] DIANA J,BREZAR V,BEAUDOIN L,et al.Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay [J].J Exp Med,2011,208(4):729-745.DOI: 10.1084/jem.20101692.
[19] GHAZARIAN L,DIANA J,BEAUDOIN L,et al.Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages [J].Diabetes,2013,62(11):3785-3796.DOI: 10.2337/db12-0958.
[20] BEAUDOIN L,DIANA J,GHAZARIAN L,et al.Plasmacytoid dendritic cells license regulatory T cells,upon iNKT-cell stimulation,to prevent autoimmune diabetes [J].Eur J Immunol,2014,44(5):1454-1466.DOI: 10.1002/eji.201343910.
[21] SCHEUPLEIN F,LAMONT D J,POYNTER M,et al.Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo [J].PLoS One,2015,10(10):e0140729.DOI: 10.1371/journal.pone.0140729.
[22] MAGALHAES I,KIAF B,LEHUEN A,et al.iNKT and MAIT Cell Alterations in Diabetes [J].Front Immunol,2015,6:341.DOI: 10.3389/fimmu.2015.00341.
[23] VALLOIS D,GAGNERAULT M C,AVNER P,et al.Influence of a non-NK complex region of chromosome 6 on CD4+ invariant NK T cell homeostasis [J].Immunol,2008,181(3):1753-1759.DOI:10.4049/jimmunol.181.3.1753.
[24] CAIELLI S,SORINI C,FALCONE M.The dangerous liaison between iNKT cells and dendritic cells: does it prevent or promote autoimmune diseases? [J].Autoimmunity,2011,44(1):11-22.

T1D发病中的双刃剑——iNKT细胞

The double-edged sword in the pathogenesis of T1D—iNKT cells

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