与血管性痴呆大鼠学习记忆力相关的基因表达变化

doi:10.3969/j.issn.1674-490X.2011.04.021

摘要/Abstract

摘要： 血管性痴呆( vascular dementia,VD)是由各种脑血管因素(缺血或出血及急慢性缺氧性脑血管病)导致脑组织损害而引起的获得性智能损害综合征,以记忆、认知功能缺损为主,可伴有语言、视空间技能及人格障碍.近年来VD的发病率及病死率逐年上升,在世界范围内已成为继心脏病、癌症之后处第3位的致死性疾病.随着社会的进步和科技的发展,人类的平均寿命提高,人口老龄化已经成为全世界面临的重大社会和医学问题,严重威胁老年人的生命和生存质量,而且中国的VD发病呈逐年上升的趋势.近年来,诸多学者对VD对于记忆能力的影响做了各方面的研究,主要对与VD大鼠记忆力相关的凋亡相关基因、蛋白类、相关因子类等进行综述.

中图分类号:

张新颖,武变瑛,范淑娟,李利平,牛培,曹松云,王淼. 与血管性痴呆大鼠学习记忆力相关的基因表达变化[J]. 医学研究与教育, 2011, 28(4): 78-83.

ZHANG Xinying,WU Bianying,FAN Shujuan,LI Liping,NIU Pei,CAO Songyun,WANG Miao. Gene expression changes related the study memory of vascular dementia rats[J]. Medical Reserch and Education, 2011, 28(4): 78-83.

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