S100B蛋白在围产医学中的研究进展

doi:10.3969/j.issn.1674-490X.2013.04.019

医学研究与教育 ›› 2013, Vol. 30 ›› Issue (4): 75-79.DOI: 10.3969/j.issn.1674-490X.2013.04.019

S100B蛋白在围产医学中的研究进展

龙爱云¹,瓮占平²

1.涞源县中医院妇产科,河北涞源,074300
2.青岛市立医院妇产科,山东青岛,266000

收稿日期:2016-10-09 修回日期:2016-10-09 出版日期:2013-08-25 发布日期:2013-08-25

Developments of S100B protein in perinatal medicine

LONG Aiyun¹,WENG Zhanping²

Received:2016-10-09 Revised:2016-10-09 Online:2013-08-25 Published:2013-08-25

摘要/Abstract

摘要： 国内外学者确定围产儿脑损伤的基本诊断步骤主要是建立在临床表现、大脑超声、动态脑电图监测、脑脊液检查、脑部CT、MRI、及多普勒的基础之上，但这些方法具有不便利性、复杂性、动态监测性差、医疗费用高、发现脑损伤时间较晚等缺点，这就导致临床上不能及早诊断及采取治疗措施。而脑自身成份S100B作为神经系统细胞损伤的直接预测因子，具有敏感性高、便于操作、重复性好、可以进行动态监测等优点，同时还可以对脑损伤程度进行定量观察。现就S100B蛋白的生物学特性、检测及其在围产医学中的应用进行综述。

关键词: S100B蛋白, 孕龄, 胎儿生长受限, 新生儿缺血缺氧性脑病

Abstract: The fundamental diagnostic procedures of perinatal brain injury determined by domestic and foreign scholars are based on the clinical manifestations, cerebral ultrasound, dynamic electroencephalogram monitoring, cerebrospinal lfuid examination, cerebral CT, MRI and doppler ultrasound. However, these methods mentioned above have some shortcomings, such as inconvenience, complexity, poor dynamic monitoring, high medical cost, late for ifnding the brain injury, et.al, which often result in slow diagnosis and treatment. However, the S100B protein coming from the brain itself, as the direct predictive factors of cell injury in nervous system, have some advantages, such as high sensitivity, easy operation, good reproducibility, easy dynamic monitoring, et.al. Furthermore, it can quantitatively observe the brain injury. The paper introduces the biological characteristics, detection methods of S100B protein and the recent developments of its applications in perinatal medicine.

Key words: S100B protein, gestational age, fetal growth restriction, neonatal hypoxic ischemic encephalopathy

中图分类号:

R715

龙爱云,瓮占平. S100B蛋白在围产医学中的研究进展[J]. 医学研究与教育, 2013, 30(4): 75-79.

LONG Aiyun,WENG Zhanping. Developments of S100B protein in perinatal medicine[J]. Medical Reserch and Education, 2013, 30(4): 75-79.

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S100B蛋白在围产医学中的研究进展

Developments of S100B protein in perinatal medicine

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