孟鲁司特钠佐治儿童肺炎支原体肺炎的疗效与安全性 meta 分析

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (5): 29-33.

孟鲁司特钠佐治儿童肺炎支原体肺炎的疗效与安全性 meta 分析

方玉婷，姜玲，史天陆，孙言才

安徽医科大学附属省立医院药剂科，安徽合肥 230001

出版日期:2014-10-25 发布日期:2014-10-25
通讯作者: 姜玲（1963—），女，安徽合肥人，主任药师，主要从事医院药学研究。E-mail: ahslyyjl@126.com
作者简介:方玉婷（1982—），女，安徽合肥人，药师，硕士，主要从事临床药学研究。E-mail: 29144389@qq.com

A meta-analysis of the effects and safety of montelukast sodium in treating mycopeasmae pneumonia in children

FANG Yuting, JIANG Ling, SHI Tianlu, SUN Yancai

Department of Pharmacy, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China

Online:2014-10-25 Published:2014-10-25

摘要/Abstract

摘要： 目的评价孟鲁司特钠佐治儿童肺炎支原体肺炎的疗效及安全性，为儿童肺炎支原体肺炎辅助治疗提供合理的用药方案和临床依据。方法通过检索中国全文期刊、维普、万方、PubMed，EMbase 等数据库 2000—2013 年发表的相关论文，根据纳入标准对文献进行筛选和评估，采用 RevMan 5.1 软件对数据进行 meta 分析。结果经筛选最终纳入符合标准的文献 5 篇，meta 分析结果显示，实验组患儿发热、咳嗽、喘息及肺部啰音消失时间优于对照组（P<0.05）。结论孟鲁司特钠可佐治儿童肺炎支原体肺炎，但由于纳入的研究质量较低 , 该结论尚需大样本的随机双盲对照试验加以验证。

关键词: meta 分析, 肺炎支原体肺炎, 儿童, 孟鲁司特钠

Abstract: Objective To evaluate the efficacy and safety of montelukast sodium in treating mycopeasmae pneumonia in children and provide reasonable medication and clinical basis for the treatment of mycoplasma pneumonia in children.Methods The related articles selected from Tosearch cnki, VIP, Wanfang, PubMed, EMbase from 2000 to 2013, according to the inclusion criteria, were selected and evaluated. All data were meta-analyzed using RevMan 5.1 software. Results 5 RCT were selected according to the inclusion criteria, the results of meta-analysis showed that: disappearance time of patients’ fever, cough, wheezing, and pulmonary rales of observation group was shorter than that of the control group (P<0.05). Conclusion According to the available data, montelukast sodium has definite clinical efficacy and safety in the treatment of of mycopeasmae pneumonia in children. However, due to poor quality and small sample size of included studies, it is necessary to carry out more high-quality clinical trials to verify this result.

Key words: meta-analysis;mycoplasma pneumoniae pneumonia, children, Montelukast Sodium

中图分类号:

R917

方玉婷，姜玲，史天陆，孙言才. 孟鲁司特钠佐治儿童肺炎支原体肺炎的疗效与安全性 meta 分析[J]. 医学研究与教育, 2014, 31(5): 29-33.

FANG Yuting, JIANG Ling, SHI Tianlu, SUN Yancai. A meta-analysis of the effects and safety of montelukast sodium in treating mycopeasmae pneumonia in children[J]. Medical Reserch and Education, 2014, 31(5): 29-33.

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