糖尿病患者不同时期球后血管血流动力学变化

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (2): 35-39.

糖尿病患者不同时期球后血管血流动力学变化

王晶¹，韦旭²

1. 承德医学院，河北承德 066000；2. 保定市第二医院眼科，河北保定 071051

出版日期:2015-04-25 发布日期:2015-04-25
通讯作者: 韦旭（1969—），女，河北保定人，主任医师，硕士，硕士生导师，主要从事眼底病相关研究。E-mail: 1781834012@qq.com
作者简介:王晶（1988—），女，河北保定人，在读硕士。

Changes of retrobulbar vascular hemodynamics in patients with diabetes at different periods

WANG Jing¹, WEI Xu²

1. Chengde Medical University, Chengde 066000, China; 2. Department of Ophthalmology, NO.2 Hospital of Baoding, Baoding 071051,China

Online:2015-04-25 Published:2015-04-25

摘要/Abstract

摘要： 目的利用彩色超声多普勒成像（CDI）技术对糖尿病视网膜病变（DR）患者球后血管血流动力学变化进行相关研究。方法选取确诊为糖尿病（DM）的患者纳入 DM 组，分为无视网膜病变（NDR）组、非增殖性视网膜病变（NPDR）组、增殖性视网膜病变（PDR）组。设立健康对照（HC）组，应用 CDI 检测研究对象颈动脉（CA）、眼动脉（OA）、视网膜中央动脉（CRA）及视网膜中央静脉（CRV）血流参数并进行比较分析。结果与 HC 组比较，NDR 期 CA、OA 血流及颈动脉中内膜厚度（IMT）变化不明显，但 CRA、CRV 出现收缩期峰值流速（PSV）和舒张末期血流速度（EDV）增加（P<0.05）；NPDR 及 PDR 期 CA、OA 及 CRA 的 PSV、EDV 呈下降趋势（P<0.05），阻力指数（RI）、搏动指数（PI）及 IMT 增高（P<0.05）。结论 CDI 技术对 DR 早期诊断有一定参考价值，虽在准确判断视网膜血液循环方面还存在局限性，但可为判断预后及分析病变提供重要信息。

关键词: 糖尿病视网膜病变, 血流动力学, 彩色超声多普勒成像技术

Abstract: Objective To study the changes of retrobulbar vascular hemodynamics in patients with diabetic retinopathy (DR) by using color Doppler imaging technology (CDI). Methods The diagnosed patients withdiabetic mellitus (DM) were divided into non-diabetic retinopathy (NDR) group, non-proliferative diabetic retinopathy (NPDR) group and proliferative diabetic retinopathy (PDR) group. The healthy patients were servedas control (HC) group. The states of carotid artery (CA), ophthalmic artery (OA), central retinal artery (CRA) and central retinal vein (CRV) blood flow parameters were examined with CDI and the results were analyzed. Results Compared with HC group, the blood flow of carotid artery(CA), ophthalmic artery(OA) and the intimamedia thickness (IMT) changes were not obvious in the patients with non-diabetic retinopathy(NDR), but the appearance of CRA peak systolic velocity (PSV) and end diastolic velocity (EDV)increased (P<0.05); phase NDR, CRV increased velocity (P<0.05). In NPDR group and PDR group, PSV, EDV in CA, OA and CRA decreased (P<0.05), resistance index (RI) and pulsatility index (PI) increased (P<0.05). Conclusion There is a reference value for the early diagnosis of DR using color Doppler imaging, but it has limitations in the accurate judgment of retinal blood circulation, however, it can be applied to provide some important information for prognosis and analysis of the degree of lesion.

Key words: diabetic retinopathy, hemodynamics, color Doppler imaging technology

中图分类号:

王晶，韦旭. 糖尿病患者不同时期球后血管血流动力学变化[J]. 医学研究与教育, 2015, 32(2): 35-39.

WANG Jing, WEI Xu. Changes of retrobulbar vascular hemodynamics in patients with diabetes at different periods[J]. Medical Reserch and Education, 2015, 32(2): 35-39.

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