AMP激活蛋白激酶在癌症代谢中的效用

doi:10.3969/j.issn.1674-490X.2025.01.001

摘要/Abstract

摘要： AMP激活蛋白激酶(AMP-activated protein kinase, AMPK)是细胞能量感知器,通过调控代谢维持能量稳定。低能量激活AMPK,增强分解代谢的同时抑制合成代谢。这一机制为ATP的产生提供了有力支持,确保细胞在能量应激状态时有效利用资源以适应环境的变化。AMPK在癌症中的作用呈现双重性:一方面,AMPK被激活后,借助其对糖代谢、脂质代谢等途径的调节,稳定癌细胞内能量水平,从而对癌细胞的增殖和转移加以遏制;另一方面,AMPK通过调控癌症代谢维持其能量稳定,进而对癌细胞的生存起促进作用。现将从AMPK的结构、生物学功能及其在癌症中的双重作用展开综述,旨在为癌症的治疗及诊断带来新的思路和策略。

关键词: AMP激活蛋白激酶, 能量稳定, 癌症代谢, 糖代谢, 脂质代谢

Abstract: AMP-activated protein kinase(AMPK)acts as a cellular energy sensor, which can maintain energy stability by regulating metabolism. Under a low-energy circumstance, AMPK is activated, enhancing catabolism while inhibiting anabolism. This mechanism provides strong support for the production of ATP, ensuring that cells can efficiently utilizing resources to adapt to changes in environmental conditions in the face of energy stress. The role of AMPK in cancer is twofold: on the one hand, after AMPK is activated, it regulates the pathways of carbohydrate metabolism and lipid metabolism to keep the intracellular energy level stable, thereby curbing the proliferation and metastasis of cancer cells. On the other hand, AMPK plays a role in promoting the survival of cancer cells by regulating cancer metabolism and maintaining its energy stability. Here, we will deeply review the structure and biological function of AMPK, dual role of AMPK in cancer, aiming to bring new ideas and strategies for cancer treatment and diagnosis.

Key words: AMP-activated protein kinase, energy stability, cancer metabolism, carbohydrate metabolism, lipid metabolism

中图分类号:

Q591

李文娟,贾怡明,唐雪. AMP激活蛋白激酶在癌症代谢中的效用[J]. 医学研究与教育, 2025, 42(1): 1-13.

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