锌离子在脊髓损伤修复中的研究进展

doi:10.3969/j.issn.1674-490X.2026.03.001

摘要/Abstract

摘要： 脊髓损伤是一种严重的中枢神经系统疾病。原发性损伤会进一步触发炎症、氧化应激、神经元凋亡等继发性损伤,最终导致患者的运动与感觉功能丧失。金属离子在维持生命活动中具有重要作用,其中锌离子已被证实可在脊髓损伤修复中发挥关键的保护作用。锌离子可以通过调控多种信号通路,缓解损伤程度,促进神经功能的恢复。从作用机制和作用方式方面系统梳理近年来锌离子在脊髓损伤领域的研究进展,以期为其临床转化与应用提供理论依据和参考。

关键词: 脊髓损伤, 锌离子, 神经保护, 信号通路, 修复机制

Abstract: Spinal cord injury is a severe disorder of the central nervous system. The first injury directly damages tissue. Then these secondary problems, such as inflammation, oxidative stress, and poor nerve regeneration, lead to the loss of motor and sensory function in patients. Metal ions play essential roles in biological systems. Among them, zinc ions has attracted growing attention for its neuroprotective potential after the spinal cord injury. Zinc ions regulate multiple signaling pathways to reduce the severity of primary and secondary damage and promote neural function recovery. This review systematically summarizes recent research progress on zinc ions in the field of spinal cord injury, covering mechanisms of action, and therapeutic strategies. The goal of this review is to provide a theoretical basis and reference for their clinical translation and application.

Key words: spinal cord injury, zinc ions, neuroprotection, signaling pathways, repair mechanisms

中图分类号:

R744

张燕,张家琪,史晓灿,王文博,王晗叶,郭涛,刘丰. 锌离子在脊髓损伤修复中的研究进展[J]. 医学研究与教育, 2026, 43(3): 1-10.

Zhang Yan, Zhang Jiaqi, Shi Xiaocan, Wang Wenbo, Wang Hanye, Guo Tao, Liu Feng. Advances on zinc ions for spinal cord injury repair[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(3): 1-10.

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