人参皂苷抗皮肤衰老的研究进展

doi:10.3969/j.issn.1674-490X.2026.03.002

摘要/Abstract

摘要： 在全球人口老龄化加剧的背景下,由皮肤衰老引起的各类外观改变及其对生活质量的影响,已成为皮肤科学与美容医学领域的研究热点。人参皂苷作为人参属植物发挥药效的核心物质基础,在延缓皮肤衰老、修复光损伤等方面展现显著的生物学活性。系统综述人参皂苷抗衰老的多靶点机制,并针对天然皂苷生物利用度低的瓶颈,重点分析稀有皂苷转化及新型经皮递送系统的应用潜能,旨在为开发高功效的人参皂苷类护肤品提供科学依据。

关键词: 人参皂苷, 皮肤衰老, 生物转化, 递送系统

Abstract: Against the epidemiological backdrop of the intensifying global population aging, various aesthetic changes caused by skin aging and their impact on quality of life have become research hotspots in the fields of dermatology and aesthetic medicine. Ginsenosides, as the core pharmacodynamic material basis of Panax plants, exhibit significant biological activities in delaying skin aging and repairing photo-damage. This paper systematically reviews the multi-target anti-aging mechanisms of ginsenosides. Furthermore, addressing the bottleneck of the low bioavailability of natural ginsenosides, it focuses on analyzing the biotransformation of rare ginsenosides and the application potential of novel transdermal delivery systems, aiming to provide a scientific basis for the development of high-efficacy ginsenoside-based skincare products.

Key words: ginsenosides, skin aging, biotransformation, delivery systems

中图分类号:

R285

陈先鹏,周玥. 人参皂苷抗皮肤衰老的研究进展[J]. 医学研究与教育, 2026, 43(3): 11-23.

Chen Xianpeng, Zhou Yue. Advances on the anti-skin aging effects of ginsenosides[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(3): 11-23.

参考文献

[1] Naharro-Rodriguez J, Bacci S, Hernandez-Bule M L, et al. Decoding skin aging: a review of mechanisms, markers, and modern therapies[J]. Cosmetics, 2025, 12(4): 144. DOI: 10.3390/cosmetics12040144.
[2] Cong L L, Ma J L, Zhang Y D, et al. Effect of anti-skin disorders of ginsenosides:a systematic review[J]. J Ginseng Res, 2023, 47(5): 605-614. DOI: 10.1016/j.jgr.2023.04.005.
[3] Wan S C, Liu Y N, Shi J J, et al. Anti-photoaging and anti-inflammatory effects of ginsenoside Rk3 during exposure to UV irradiation[J]. Front Pharmacol, 2021, 12: 716248. DOI: 10.3389/fphar.2021.716248.
[4] Kim J, Phung H M, Lee S, et al. Anti-skin-aging effects of tissue-cultured mountain-grown ginseng and quantitative HPLC/ELSD analysis of major ginsenosides[J]. J Nat Med, 2022, 76(4): 811-820. DOI: 10.1007/s11418-022-01633-2.
[5] Kim H, Lee J H, Kim J E, et al. Micro-/ nano-sized delivery systems of ginsenosides for improved systemic bioavailability[J]. J Ginseng Res, 2018, 42(3): 361-369. DOI: 10.1016/j.jgr.2017.12.003.
[6] Hu Q R, Hong H, Zhang Z H, et al. Methods on improvements of the poor oral bioavailability of ginsenosides: pre-processing, structural modification, drug combination, and micro- or nano- delivery system[J]. J Ginseng Res, 2023, 47(6): 694-705. DOI: 10.1016/j.jgr.2023.07.005.
[7] Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells[J]. Nat Rev Mol Cell Biol, 2007, 8(9): 729-740. DOI: 10.1038/nrm2233.
[8] Liu Z B, Sun C, Zhang Z F, et al. Telomeres in skin aging[J]. Biogerontology, 2025, 26(2): 83. DOI: 10.1007/s10522-025-10228-9.
[9] Tanveer M A, Rashid H, Tasduq S A. Molecular basis of skin photoaging and therapeutic interventions by plant-derived natural product ingredients: a comprehensive review[J]. Heliyon, 2023, 9(3): e13580. DOI: 10.1016/j.heliyon.2023.e13580.
[10] Krutmann J, Bouloc A, Sore G, et al. The skin aging exposome[J]. J Dermatol Sci, 2017, 85(3): 152-161. DOI: 10.1016/j.jdermsci.2016.09.015.
[11] Hussen N H A, Abdulla S K, Ali N M, et al. Role of antioxidants in skin aging and the molecular mechanism of ROS: a comprehensive review[J]. Aspects Mol Med, 2025, 5: 100063. DOI: 10.1016/j.amolm.2025.100063.
[12] Feng C, Chen X L, Yin X Q, et al. Matrix metalloproteinases on skin photoaging[J]. J Cosmet Dermatol, 2024, 23(12): 3847-3862. DOI: 10.1111/jocd.16558.
[13] Gu X Y, Li Z R, Su J. Air pollution and skin diseases: a comprehensive evaluation of the associated mechanism[J]. Ecotoxicol Environ Saf, 2024, 278: 116429. DOI: 10.1016/j.ecoenv.2024.116429.
[14] Li Y M, Tian X T, Luo J Y, et al. Molecular mechanisms of aging and anti-aging strategies[J]. Cell Commun Signal, 2024, 22(1): 285. DOI: 10.1186/s12964-024-01663-1.
[15] Xu X Y, Pang Y, Fan X Q. Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances[J]. Sig Transduct Target Ther, 2025, 10: 190. DOI: 10.1038/s41392-025-02253-4.
[16] Lee H J, Yoon Y S, Lee S J. Molecular mechanisms of cellular senescence in neurodegenerative diseases[J]. J Mol Biol, 2023, 435(12): 168114. DOI: 10.1016/j.jmb.2023.168114.
[17] Pilkington S M, Bulfone-Paus S, Griffiths C E M, et al. Inflammaging and the skin[J]. J Investig Dermatol, 2021, 141(4): 1087-1095. DOI: 10.1016/j.jid.2020.11.006.
[18] Wang Z Y, Yuan F M, Zhong X W, et al. Skin microbiome and skin aging: emerging strategies for manipulation[J]. Microbiol Res, 2025, 300: 128285. DOI: 10.1016/j.micres.2025.128285.
[19] Wang K, Liu H C, Hu Q C, et al. Epigenetic regulation of aging: implications for interventions of aging and diseases[J]. Sig Transduct Target Ther, 2022, 7(1): 374. DOI: 10.1038/s41392-022-01211-8.
[20] Mohanan P, Subramaniyam S, Mathiyalagan R, et al. Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions[J]. J Ginseng Res, 2018, 42(2): 123-132. DOI: 10.1016/j.jgr.2017.01.008.
[21] Liu Y N, Qu L L, Wan S C, et al. Ginsenoside Rk1 prevents UVB irradiation-mediated oxidative stress, inflammatory response, and collagen degradation via the PI3K/AKT/NF-κB pathway in vitro and in vivo[J]. J Agric Food Chem, 2022, 70(50): 15804-15817. DOI: 10.1021/acs.jafc.2c06377.
[22] Xia W, Zhu Z D, Xiang S, et al. Ginsenoside Rg5 promotes wound healing in diabetes by reducing the negative regulation of SLC7A11 on the efferocytosis of dendritic cells[J]. J Ginseng Res, 2023, 47(6): 784-794. DOI: 10.1016/j.jgr.2023.06.006.
[23] Shin D, Moon H W, Oh Y, et al. Defensive properties of ginsenoside Re against UV-B-induced oxidative stress through up-regulating glutathione and superoxide dismutase in HaCaT keratinocytes[J]. Iran J Pharm Res, 2018, 17(1): 249-260.
[24] Yang K E, Jang H J, Hwang I H, et al. Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling[J]. J Ginseng Res, 2020, 44(2): 341-349. DOI: 10.1016/j.jgr.2019.08.002.
[25] Kim E, Kim D, Yoo S, et al. The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng[J]. J Ginseng Res, 2018, 42(2): 218-224. DOI: 10.1016/j.jgr.2017.03.007.
[26] Kim S, Kang B Y, Cho S Y, et al. Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin[J]. Biochem Biophys Res Commun, 2004, 316(2): 348-355. DOI: 10.1016/j.bbrc.2004.02.046.
[27] Xia Z, Liu W, Zeng F M, et al. Systematic evaluation and identification of anti-inflammatory and anti-aging ginseng peptides for skincare applications[J]. Cosmetics, 2025, 12(2): 85. DOI: 10.3390/cosmetics12020085.
[28] Hou J G, Kim S. Possible role of ginsenoside Rb1 in skin wound healing via regulating senescent skin dermal fibroblast[J]. Biochem Biophys Res Commun, 2018, 499(2): 381-388. DOI: 10.1016/j.bbrc.2018.03.170.
[29] Park S H, Seo W, Eun H S, et al. Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice[J]. Biochem Biophys Res Commun, 2016, 478(4): 1713-1719. DOI: 10.1016/j.bbrc.2016.09.009.
[30] Liu X Y, Hwang E, Park B, et al. Ginsenoside C-mx isolated from notoginseng stem-leaf ginsenosides attenuates ultraviolet B-mediated photoaging in human dermal fibroblasts[J]. Photochem Photobiol, 2018, 94(5): 1040-1048. DOI: 10.1111/php.12940.
[31] Kang H J, Huang Y H, Lim H W, et al. Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes[J]. J Photochem Photobiol B Biol, 2016, 165: 232-239. DOI: 10.1016/j.jphotobiol.2016.10.034.
[32] Jung E M, Lee G S. Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic[J]. J Ginseng Res, 2022, 46(3): 331-336. DOI: 10.1016/j.jgr.2022.02.003.
[33] Lee W J, Kim E N, Trang N M, et al. Ameliorative effect of ginsenoside Rg6 in periodontal tissue inflammation and recovering damaged alveolar bone[J]. Molecules, 2023, 29(1): 46. DOI: 10.3390/molecules29010046.
[34] Li D X, Luo Z B, Zhu J, et al. Ginsenoside F2-mediated intestinal microbiota and its metabolite propionic acid positively impact the gut-skin axis in atopic dermatitis mice[J]. J Agric Food Chem, 2024, 72(1): 339-350. DOI: 10.1021/acs.jafc.3c06015.
[35] Lee S J, Lee W J, Chang S E, et al. Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor[J]. J Ginseng Res, 2015, 39(3): 238-242. DOI: 10.1016/j.jgr.2015.01.001.
[36] Ma A T, Zhu S Y, Yao X W, et al. Ginsenoside Rg3 inhibits melanoma progression by inducing ferroptosis via the p53/SLC7A11/GPX4 pathway[J]. J Adv Res, 2025: S2090-S1232(25)00864-1. DOI: 10.1016/j.jare.2025.10.069.
[37] Liu J Z, Xu X H, Zhou J Y, et al. Phenolic acids in Panax ginseng inhibit melanin production through bidirectional regulation of melanin synthase transcription via different signaling pathways[J]. J Ginseng Res, 2023, 47(6): 714-725. DOI: 10.1016/j.jgr.2023.05.002.
[38] Yang K E, Nam S B, Jang M, et al. Ginsenoside Rb2 suppresses cellular senescence of human dermal fibroblasts by inducing autophagy[J]. J Ginseng Res, 2023, 47(2): 337-346. DOI: 10.1016/j.jgr.2022.11.004.
[39] Lee C S, Nam G, Bae I H, et al. Whitening efficacy of ginsenoside F1 through inhibition of melanin transfer in cocultured human melanocytes-keratinocytes and three-dimensional human skin equivalent[J]. J Ginseng Res, 2019, 43(2): 300-304. DOI: 10.1016/j.jgr.2017.12.005.
[40] Hou J G, Yun Y, Jeon B, et al. Ginsenoside F1-mediated telomere preservation delays cellular senescence[J]. Int J Mol Sci, 2023, 24(18): 14241. DOI: 10.3390/ijms241814241.
[41] Li S G, Yan M Z, Zhang D, et al. Effects of ginsenoside Rg1 on the senescence of vascular smooth muscle cells[J]. Genet Mol Res, 2016, 15(3): 15038409. DOI: 10.4238/gmr.15038409.
[42] Wang Z K, Chen L, Zhang Y N, et al. An injectable, anti-inflammatory, and angiogenesis-promoting dual crosslinked hydrogel loaded with ginsenoside Rg1 on wound healing[J]. Macromol Biosci, 2026, 26(1): e00228. DOI: 10.1002/mabi.202500228.
[43] Jeong G, Shin S H, Kim S N, et al. Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells[J]. J Ginseng Res, 2023, 47(3): 440-447. DOI: 10.1016/j.jgr.2022.11.002.
[44] Fang C, Yang H X, Zhu C H, et al. Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β-catenin and p53 signaling pathways in AGA mice[J]. Food Front, 2023, 4(3): 1270-1284. DOI: 10.1002/fft2.272.
[45] Choi W, Cho J H, Park S H, et al. Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species[J]. J Ginseng Res, 2024, 48(2): 211-219. DOI: 10.1016/j.jgr.2024.01.001.
[46] Yang S, Lu S Y, Ren L M, et al. Ginseng-derived nanoparticles induce skin cell proliferation and promote wound healing[J]. J Ginseng Res, 2023, 47(1): 133-143. DOI: 10.1016/j.jgr.2022.07.005.
[47] Zhou B, Wu L, Liu D H, et al. Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/ENOS/NO axis[J]. J Ginseng Res, 2025, 49(6): 683-691. DOI: 10.1016/j.jgr.2025.06.002.
[48] Yu X M, Lu Y, Chen J J, et al. Unlocking ginsenosides' therapeutic power with polymer-based delivery systems: current applications and future perspectives[J]. Front Pharmacol, 2025, 16: 1629803. DOI: 10.3389/fphar.2025.1629803.
[49] Quan L H, Piao J Y, Min J W, et al. Bioconversion of ginsenoside Rb1 into compound k by Leuconostoc citreum LH1 isolated from kimchi[J]. Publ Braz Soc Microbiol, 2011, 42(3): 1227-1237. DOI: 10.1590/S1517-838220110003000049.
[50] Kim W H, Kim J E, Kim S, et al. Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function[J]. Heliyon, 2023, 9(4): e14803. DOI: 10.1016/j.heliyon.2023.e14803.
[51] Jo S K, Kim I S, Yoon K S, et al. Preparation of ginsenosides Rg3, Rk1, and Rg5-selectively enriched ginsengs by a simple steaming process[J]. Eur Food Res Technol, 2015, 240(1): 251-256. DOI: 10.1007/s00217-014-2370-1.
[52] Vo H T, Cho J Y, Choi Y E, et al. Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1[J]. J Ginseng Res, 2015, 39(4): 304-313. DOI: 10.1016/j.jgr.2015.02.003.
[53] Lee S H, Kim K M, Kim D, et al. Changes in ginsenoside patterns of red ginseng extracts according to manufacturing and storage conditions[J]. Food Sci Biotechnol, 2017, 26(6): 1735-1741. DOI: 10.1007/s10068-017-0149-4.
[54] Choi J H, Cho S H, Yun J J, et al. Ethosomes and transfersomes for topical delivery of ginsenoside rhl from red ginseng: characterization and in vitro evaluation[J]. J Nanosci Nanotechnol, 2015, 15(8): 5660-5662. DOI: 10.1166/jnn.2015.10462.
[55] Jin Y Y, Liu D, Lu Z, et al. Preparation and evaluation of liposomes and niosomes containing total ginsenosides for anti-photoaging therapy[J]. Front Bioeng Biotechnol, 2022, 10: 874827. DOI: 10.3389/fbioe.2022.874827.
[56] Hou P P, Pu F L, Zou H Y, et al. Whey protein stabilized nanoemulsion: a potential delivery system for ginsenoside Rg3 whey protein stabilized nanoemulsion: potential Rg3 delivery system[J]. Food Biosci, 2019, 31: 100427. DOI: 10.1016/j.fbio.2019.100427.
[57] Yang Q, Guo P, Lei P K, et al. Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment[J]. Regen Biomater, 2024, 11: rbae086. DOI: 10.1093/rb/rbae086.
[58] Cho E G, Choi S Y, Kim H, et al. Panax ginseng-derived extracellular vesicles facilitate anti-senescence effects in human skin cells: an eco-friendly and sustainable way to use ginseng substances[J]. Cells, 2021, 10(3): 486. DOI: 10.3390/cells10030486.