厄贝沙坦联合胺碘酮对阵发性房颤患者转律及窦性心律维持的临床研究

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (6): 41-45.

厄贝沙坦联合胺碘酮对阵发性房颤患者转律及窦性心律维持的临床研究

张兰芳¹，陈彦霞¹，赵淑君¹，解俊敏¹，陈美鹤²，张进尊²，韩昆鹏³

1.河北大学附属医院，河北保定 071000；2.河北省保定市新市区医院，河北保定 071000；3.河北省保定市高阳县中医院，河北高阳 071500

出版日期:2014-12-25 发布日期:2014-12-25
通讯作者: 陈美鹤（1980—），女，河北保定人，主管护师，主要从事心律失常疾病的护理。E-mail: zlf_doc@126.com
作者简介:张兰芳（1979—），女，河北高阳人，主治医师，主要从事高血压病及心律失常疾病的诊疗。E-mail: ache911@126.com

Clinical research of irbesartan combined with amiodarone in rebuilding and maintaining sinus rhythm in patients with paroxysmal atrial fibrillation

ZHANG Lanfang¹, CHEN Yanxia¹, ZHAO Shujun¹, XIE Junmin¹, CHEN Meihe², ZHANG Jinzun², HAN Kunpeng³

1. Affiliated Hospital of Hebei University,Baoding 071000; China; 2. Baoding New District Hospital, Baoding 071000, China; 3. Gaoyang Hospital of Traditional Chinese Medicine, Gaoyang 071500, China

Online:2014-12-25 Published:2014-12-25

摘要/Abstract

摘要： 目的探讨厄贝沙坦联合胺碘酮对阵发性房颤转律及窦性心律维持的临床疗效。方法选择阵发性房颤患者100例，随机分为两组：对照组（48 例）和治疗组（52 例）。对照组给予胺碘酮治疗，治疗组在应用胺碘酮基础上加服厄贝沙坦治疗。随访 1 年，观察两组治疗前后左心房内径（LAD）、左室射血分数（LVEF）、血清超敏 C- 反应蛋白（hs-CRP）变化、心房颤动转复率及窦性心律维持率。结果治疗组 LAD 明显缩小、LVEF明显升高，房颤转复率及窦性心律维持率明显优于对照组（P<0.05）；两组治疗后 hs-CRP较治疗前均有下降，但治疗组优于对照组（P<0.05）。结论厄贝沙坦联合胺碘酮可明显抑制心房重构、改善心功能，提高阵发性房颤患者心律转复率，降低复发率，作用优于单独应用胺碘酮，并能有效降低血清 hs-CRP 水平。

关键词: 厄贝沙坦, 胺碘酮, 超敏 C- 反应蛋白, 阵发性房颤

Abstract: Objective To discuss the clinical effect of irbesartan combined with amiodarone in rebuilding and maintaining sinus rhythm in patients with paroxysmal atrial fibrillation. Methods 100 patients with paroxysmal atrial fibrillation randomly were divided into control group (n=48) and therapeutic group (n=52).Both groups received amiodarone, therapeutic group received irbesartan additionally.All patients were follwed up for 1year. The diameter of left atrium (LAD), left ventricular ejection fraction (LVEF) and the level of hs-CRP were counted, The rate of successful sinus rhythm rebuilding and its maintenance were also observed. Results Compared with the control group, the LAD decreased and LVEF improved in therapeutic group, the rate of successful sinus rhythm and its maintenance were significantly increased. The level of hs-CRP in both groups was lower, especially in the therapeutic group. Conclusion Irbesartan combined with amiodarone can inhibit atrial remodeling obviously, improve heart function, increase the rate of in the rebuilding of sinus rhythm and decrease its recurrence rate significantly, which is more effective than amiodarone alone.

Key words: irbesartan, amiodarone, high sensitivity C reactive protein, paroxysmal atrial fibrillation

中图分类号:

张兰芳，陈彦霞，赵淑君，解俊敏，陈美鹤，张进尊，韩昆鹏. 厄贝沙坦联合胺碘酮对阵发性房颤患者转律及窦性心律维持的临床研究[J]. 医学研究与教育, 2014, 31(6): 41-45.

ZHANGLanfang, CHEN Yanxia, ZHAO Shujun, XIE Junmin, CHEN Meihe, ZHANG Jinzun, HAN Kunpeng. Clinical research of irbesartan combined with amiodarone in rebuilding and maintaining sinus rhythm in patients with paroxysmal atrial fibrillation[J]. Medical Reserch and Education, 2014, 31(6): 41-45.

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