精子发生过程中调控性非编码 RNAs 的功能

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (6): 95-99.

精子发生过程中调控性非编码 RNAs 的功能

王燕¹，郭文龙²，耿德海²，王波³，张建立³，张艳敏⁴，刘淑卓⁵

1. 河北大学基础医学院, 河北保定 071000；2. 涞水县县医院，河北涞水074100；3. 易县县医院，河北易县 074200；4. 易县中医院，河北易县 074200；5. 河北大学附属医院，河北保定 071000

出版日期:2014-12-25 发布日期:2014-12-25
通讯作者: 刘淑卓（1971—），女，河北保定人，主管检验师，主要从事临床检验。E-mail: cimeiliuxiang@126.com
作者简介:王燕（1974—），女，满族，河北易县人，副教授，硕士，主要从事生殖毒理学教学和科研。E-mail：wyry2004@163.com,

The role of regulatory non-coding RNAs during spermatogenesis

WANG Yan¹, GUO Wenlong², GENG Dehai², WANG Bo³, ZHANG Jianli³, ZHANG anmin⁴, LIU Shuzhuo⁵

1. College of Basic Medical Sciences of Hebei University, Baoding 071000, China; 2. Laishui County Hospital, Laishui 074100, China; 3. Yixian County Hospital, Yixian 074200, China; 4. Yixian County Hospital of Traditional Chinese Medicine, Yixian 074200, China; 5. Affiliated Hospital of Hebei University, Baoding 071000, China

Online:2014-12-25 Published:2014-12-25

摘要/Abstract

摘要： 精子数量下降和质量减低是全球范围内男性不育疾病增加的主要原因。因此理解精子发生及其调控的分子机制是非常必要的。精子发生主要分为有丝分裂、减数分裂和精子形成三个阶段，这些过程被阶段特异性的基因表达严格调控，而众多的调控性非编码 RNAs则是基因表达的重要调控因子。飞速发展的基因组检测技术已经证实，调控性非编码 RNAs在不同生物演化和疾病进程中基因表达的转录和转录后水平上发挥重要的调控作用，其包括微小 RNA(miRNA)、小干扰RNA（siRNA）、与 PIWI 蛋白相互作用的 RNAs（piRNA）和长链非编码 RNA（lncRNA）。讨论这些转录本在精子发生中的功能作用，并综述其异常表达与相关疾病的关系。

关键词: 调控性非编码 RNAs, 精子发生, 基因表达, 男性不育

Abstract: Global rise in male infertility as a result of falling sperm count and quality has been pointed out by many investigations. Therefore, it is essential to understand the molecular mechanism of spermatogenesis and its regulation. Spermatogenesis is characterized by three phases: mitosis, meiosis and spermiogenesiss, which are strictly regulated by phase-specific gene expression that is controlled by myriads of regulatory non-coding RNAs. Rapid advancement in genome mining technologies has identified role of regulatory non-coding RNAs including microRNA(miRNA), small-interfering RNA(siRNA), PIWI-interacting RNA(piRNA) and long non-coding RNA(lncRNA) as controllers of gene expression at transcriptional as well as post-transcriptional level in different biological context and disease processes. Here, we discuss the recent advances in our understanding about the involvement of these transcripts in spermatogenesis. In addition, we review here the relationship between their abnormal experssion and associated diseases.

Key words: regulatory non-coding RNAs, spermatogenesis, gene expression, male infertility

中图分类号:

王燕，郭文龙，耿德海，王波，张建立，张艳敏，刘淑卓. 精子发生过程中调控性非编码 RNAs 的功能[J]. 医学研究与教育, 2014, 31(6): 95-99.

WANG Yan, GUO Wenlong, GENG Dehai, WANG Bo, ZHANG Jianli, ZHANG Yanmin, LIU Shuzhuo. The role of regulatory non-coding RNAs during spermatogenesis[J]. Medical Reserch and Education, 2014, 31(6): 95-99.

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