氨甲环酸治疗老年股骨转子间骨折髓内固定术后隐性失血的临床分析

doi:10.3969/j.issn.1674-490X.2013.06.013

医学研究与教育 ›› 2013, Vol. 30 ›› Issue (6): 51-54.DOI: 10.3969/j.issn.1674-490X.2013.06.013

氨甲环酸治疗老年股骨转子间骨折髓内固定术后隐性失血的临床分析

王晓冬¹,姜媛媛¹,王建忠¹,高文山¹,李辉²,陆健海³

1.河北大学附属医院骨科,河北保定,071000
2.河北医科大学第三医院骨科,河北石家庄,050051
3.深泽县医院骨科,河北深泽,052560

收稿日期:2016-10-09 修回日期:2016-10-09 出版日期:2013-12-25 发布日期:2013-12-25

Clinical research of tranexamic acid on the hidden blood Ioss after the treatment of intertrochanteric fractures with proximal femoral nail anti-rotation (PFNA)

WANG Xiaodong¹,JIANG Yuanyuan¹,WANG Jianzhong¹,GAO Wenshan¹,LI Hui²,LU Jianhai³

Received:2016-10-09 Revised:2016-10-09 Online:2013-12-25 Published:2013-12-25

摘要/Abstract

摘要： 目的：研究应用氨甲环酸治疗转子间骨折髓内固定术后隐性失血的疗效。方法56例老年股骨转子间骨折髓内固定患者随机分为2组。治疗组28例，术中扩髓前应用1 g氨甲环酸加入至250 mL生理盐水中静脉滴注；对照组28例，术中给予等量生理盐水静脉滴注。分别计算其总失血量、显性失血量及隐性失血量，对其结果进行对比。并术后10 d超声检查是否出现下肢静脉血栓。结果2组患者总失血量比较差异有统计学意义（P<0.05）。隐性失血平均为（426.69±56.25）mL，明显低于对照组的（658.36±60.76）mL，组间比较差异有统计学意义（P<0.05）。而显性失血差异无统计学意义（P>0.05）。超声检查所有患者无下肢深静脉血栓形成。结论应用氨甲环酸治疗能有效减少转子间骨折髓内固定术后围术期失血量及隐性失血量，减少了输血患者人数及输血量。同时未增加血栓形成风险。

关键词: 股骨转子间骨折, 隐性失血, 氨甲环酸, 失血, 手术

Abstract: Objective To assess the impact of tranexamine acid on the hidden blood loss in intertrochanteric fractures treated with proximal femoral nail anti-rotation (PFNA). Methods 56 cases patients with intertrochanteric fractured treated with PFNA were randomly divided into two groups. Group A included 28 cases with tranexanifc acid. And the patients in this group were given 1 g tranexamieacid with 250 mL normal saline when the surgery started. The controls included 28 cases without tranexamic acid, in which the patients were just given 250 mL normal saline. The total red bloodcell loss, visible red blood cell loss and hidden red blood cell loss of the two groups were measured and the comparative analysis was conducted. Results The results of the hidden red blood loss in treatment group and control group were (426.69±56.25)mL and (658.36±60.76)mL, the hidden blood cell losses in group A were both signiifcantly less than those in group B(P<0. 05). The visible blood loss was unchanged at the same time. Conclusion Ranexamic acid can reduce both the visible and hidden red blood loss after the treatment of intertrochanteric fractures with PFNA.

Key words: intertrochanteric fracture, hidden blood loss, Ranexamic acid, blood loss, surgery

中图分类号:

王晓冬,姜媛媛,王建忠,高文山,李辉,陆健海. 氨甲环酸治疗老年股骨转子间骨折髓内固定术后隐性失血的临床分析[J]. 医学研究与教育, 2013, 30(6): 51-54.

WANG Xiaodong,JIANG Yuanyuan,WANG Jianzhong,GAO Wenshan,LI Hui,LU Jianhai. Clinical research of tranexamic acid on the hidden blood Ioss after the treatment of intertrochanteric fractures with proximal femoral nail anti-rotation (PFNA)[J]. Medical Reserch and Education, 2013, 30(6): 51-54.

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氨甲环酸治疗老年股骨转子间骨折髓内固定术后隐性失血的临床分析

Clinical research of tranexamic acid on the hidden blood Ioss after the treatment of intertrochanteric fractures with proximal femoral nail anti-rotation (PFNA)

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