成人接种乙肝疫苗无/弱免疫应答的影响因素分析

doi:10.3969/j.issn.1674-490X.2013.05.023

摘要/Abstract

摘要： 接种乙肝疫苗是预防乙型肝炎病毒感染的有效措施，但有部分成年人接种乙型肝炎疫苗后往往不产生有效的保护性免疫应答。现从机体因素、疫苗因素、接种因素三个方面综述分析了成人接种乙肝疫苗后无/弱免疫应答的影响因素。

Abstract: The immunization of hepatitis B vaccine is the most effective measure to prevent hepatitis B infection, but some adults have no response to the hepatitis B vaccine. This article analyses the affective aspects of non(low)-response after the adult human body vaccination of hepatitis B vaccine, which reviews the human body factors, the vaccine factors and the vaccination factors.

Key words: hepatitis B vaccine, non/low-response in adults, affecting factors

中图分类号:

R186

王静茹,张荣贞,曹志然. 成人接种乙肝疫苗无/弱免疫应答的影响因素分析[J]. 医学研究与教育, 2013, 30(5): 87-91.

WANG Jingru,ZHANG Rongzhen,CAO Zhiran. Analysis of affecting factors of non(low)-response to hepatitis B vaccine in adults[J]. Medical Reserch and Education, 2013, 30(5): 87-91.

参考文献

[1] 赵东设, 董雷, 谢海斌, 姚军. 重组酵母乙肝疫苗接种后抗体水平分析 [J]. 上海预防医学 2008.doi:10.3969/j.issn.1004-9231.2008.11.005
[2] 时景璞, 王昕, 王桂花, 徐占民, 杨志奇, 郑力国, 李征远, 郭乃全, 吴晓音, 梁争论. 成人接种重组酵母乙型肝炎疫苗免疫效果观察 [J]. 中华预防医学杂志 2002.doi:10.3760/j:issn:0253-9624.2002.06.002
[3] 吕兰秋, 傅君芬, 梁黎, 郑乐朋, 黄应, LU Lan-qiu, FU Jun-fen, LIANG Li, ZHENG Le-peng, HUANG Ying. 单纯性肥胖儿童T细胞免疫功能及其影响因素分析 [J]. 临床儿科杂志 2006.doi:10.3969/j.issn.1000-3606.2006.09.019
[4] 翟祥军. 乙肝疫苗接种无(弱)应答的研究现状 [J]. 铁道医学 2002.doi:10.3969/j.issn.1671-7562.2002.01.034
[5] 胡丹标, 刘世科, 赵丽丽, 黄美林, 徐爱萍, 洪因之, 曹品元. 重组乙型肝炎疫苗(酵母)10μg成人免疫失败因素探讨 [J]. 中国疫苗和免疫 2008.doi:10.3969/j.issn.1006-916X.2008.04.010
[6] 孟艳丽, 韦颖华, 吴健林, 吴继周, 李国坚, 陈茂伟, 龚星光, 万裴奇, 虞艳琦, 胡蝶飞, MENG Yan-li, WEI Ying-hua, WU Jian-lin, WU Ji-zhou, LI Guo-jian, CHEN Mao-wei, GONG Xing-guang, WAN Pei-qi, YU Yan-qi, HU Die-fei. 淋巴细胞亚群对乙肝疫苗免疫效果的影响研究 [J]. 内科 2009.doi:10.3969/j.issn.1673-7768.2009.01.001
[7] Vijayakumar Velu, Shanmugam Saravanan, Subhadra Nandakumar, Esaki Muthu Shankar, Appasamy Vengatesan, Suresh Sakharam Jadhav, Prasad Suryakant Kulkarni, Sadras Panchatcharam Thyagarajan. Relationship between T-lymphocyte cytokine levels and sero-response to hepatitis B vaccines [J]. 世界胃肠病学杂志(英文版) 2008.doi:10.3748/wjg.14.3534
[8] 冯春颜, 汪宇婴, 赵祥胜, FENG Chun-yan, WANG Yu-ying, ZHAO Xiang-sheng. 乙肝疫苗接种后无弱应答分析 [J]. 热带医学杂志 2005.doi:10.3969/j.issn.1672-3619.2005.03.056
[9] 韦颖华, 吴继周, 吴健林, 李国坚, 陈茂伟, 玉艳红, 吴霜, 龚星光, 孟艳丽, 虞艳琦, WEI Ying-Hua, WU Ji-Zhou, WU Jian-Lin, LI Guo-Jian, CHEN Mao-Wei, YU Yan-Hong, WU Shuang, GONG Xing-Guang, MENG Yan-Li, YU Yan-Qi. HLA-DRB1*07, 13等位基因对乙肝疫苗免疫效果影响的研究 [J]. 中国免疫学杂志 2009.
[10] 黄晓晖, 陈思东, HUANG Xiao-hui, CHEN Si-dong. 乙肝疫苗无、弱应答与HLA-DRB1*07、DQB1*02相关性的研究 [J]. 广东药学院学报 2011.doi:10.3969/j.issn.1006-8783.2011.04.021
[11] 郑忠志, 王亚辉, 祖静. 2种接种乙肝疫苗的方法比较 [J]. 蛇志 2002.doi:10.3969/j.issn.1001-5639.2002.01.019
[12] 陈胤忠, 姜仁杰, 沈进进, 陈昌标, 周聪玲, 汤权, 胡高兵, 吴巨飞. 基因重组乙型肝炎疫苗用于成人的免疫程序和接种剂量的研究 [J]. 中国计划免疫 2005.doi:10.3969/j.issn.1006-916X.2005.02.006
[13] 朱建琼, 黄振宇, 毛东波, 李粤荣. 健康人群中乙肝疫苗无(低)应答者再免疫效果研究 [J]. 实用预防医学 2008.doi:10.3969/j.issn.1006-3110.2008.06.031
[14] 蒋汝刚, 付翔, 周静, 范杉, 罗德生, JIANG Ru-gang, FU Xiang, ZHOU Jing, FAN Shan, LUO De-sheng. 成年人接种乙肝疫苗后无(弱)应答状况及其影响因素分析 [J]. 中华疾病控制杂志 2011.
[15] WOOD R C, MACDONALD K L, WHITE K E. Risk factors for lack of detectable antibody following hepatitis B vaccination of Minnesota health care workers [J]. Journal of the American Medical Association 2005, 270(05).
[16] 陈思东, 黄晓晖, 杨翌, 谭剑斌. 乙肝疫苗无、弱应答相关因素病例对照研究 [J]. 中国公共卫生 2009.
[17] 潘喜华, 杨隽, 郑勇英. 茶多酚调节免疫、抑制肿瘤及抗衰老作用的研究 [J]. 上海预防医学 2000, 12(02).
[18] Goncalves L, Albarran B, Salmen S, Borges L, Fields H, Montes H, Soyano A, Diaz Y, Berrueta L. The nonresponse to hepatitis B vaccination is associated with impaired lymphocyte activation. [J]. Virology 2004, 1(1).
[19] DESOMBERE I, CAO T, GIJBELS Y. Leroux-roels non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a la-ck of B7co-stimulation [J]. Clin Experimimmunol 2005, 140(02).
[20] 黄晓晖, 陈思东, HUANG Xiao-hui, CHEN Si-dong. HLA-DRB1*0701基因与吸烟在乙肝疫苗免疫应答中的交互作用 [J]. 公共卫生与预防医学 2009.
[21] Li X, Yang X, Li L, Liu H, Liu J. [J]. Vaccine 2006.
[22] RAHMAN F, DAHMAEN A, HERZOG H S. Cellular and humoralimmune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antige [J]. Hepatology 2000, 31(02).
[23] Playford EG, Hogan PG, Bansal AS, Harrison K, Drummond D, Looke DF, Whitby M. Intradermal recombinant hepatitis B vaccine for healthcare workers who fail to respond to intramuscular vaccine. [J]. Infection control and hospital epidemiology 2002, 2(2).