Toll样受体与脑缺血的关系及相关药物研究进展

doi:10.3969/j.issn.1674-490X.2019.01.002

摘要/Abstract

摘要： Toll样受体(TLRs)是天然免疫体系的首要调节因子,在缺血性脑损伤引起的炎症反应中发挥着不可或缺的作用。随着对脑卒中发病过程中TLRs的信号传导机制的认识逐渐深入,靶向于TLRs信号通路的治疗方法日渐成为脑卒中治疗的焦点。现将直接作用于TLRs、调节MyD88或TRIF信号通路以及TLRs配体等治疗脑卒中的药物研究进展做一综述,以期为脑卒中的机制钻研与新药开辟提供思路。

关键词: 脑缺血, Toll样受体, 药物, 炎症

Abstract: Toll-like receptors(TLRs)are critical regulators of innate immunity and inflammatory response in cerebral ischemic injury. In recent years, with a deeper understanding of the signaling mechanisms of TLRs during the onset of stroke, targeting TLRs have become a promising therapy for cerebral ischemic stroke. Medication or compounds can inhibit the inflammatory reaction in cerebral ischemia via directly acting on TLRs, modulating MyD88 or TRIF signaling pathways, and TLRs ligand preconditioning or postconditioning. This review will focus on promising therapies which exert neuroprotective effects against ischemic injury by acting on TLRs.

Key words: cerebral ischemia, Toll-like receptors, medication, inflammation

中图分类号:

R743

邱燕英,赵勃,方伟蓉,李运曼. Toll样受体与脑缺血的关系及相关药物研究进展[J]. 医学研究与教育, 2019, 36(1): 6-12.

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