瘦素的生物学作用及其相关机制研究进展

doi:10.3969/j.issn.1674-490X.2023.04.001

摘要/Abstract

摘要： 瘦素(leptin)是一种由白色脂肪细胞分泌的激素,作为脂肪组织和中枢神经系统网络联系的外周信号,影响人体的摄食、能量平衡、内分泌和免疫功能等。通过分析总结瘦素及其受体(leptin receptor,LEPR)分子结构和细胞内分布, 对其在调节脂代谢、炎症与免疫、创伤愈合及肿瘤发展等方面的研究进展进行综述。

关键词: 瘦素, 脂肪组织, 代谢, 炎症, 创伤愈合, 肿瘤

Abstract: As a hormone secreted by white fat cells, leptin acts as a peripheral signal linking adipose tissue and the central nervous system networks, affecting feeding, energy balance, endocrine and immune functions. Through the analysis and summary of molecular structure and intracellular distribution of leptin and its receptor(LEPR), the recent developments on the regulation of lipid metabolism, inflammation and immunity, wound healing and tumor development are reviewed.

Key words: leptin, adipose tissue, metabolism, inflammation, wound healing, tumors

中图分类号:

周向阳,吴迪,米甜,李文娟. 瘦素的生物学作用及其相关机制研究进展[J]. 医学研究与教育, 2023, 40(4): 1-10.

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