Klotho蛋白在急性肾损伤诊治中的研究进展

doi:10.3969/j.issn.1674-490X.2021.02.003

摘要/Abstract

摘要： Klotho基因最初被认为是一种抗衰老相关的基因,近年来该基因编码的蛋白抗炎症反应、抗氧化应激、抗凋亡、调节组织自噬和钙磷代谢等多种作用也逐渐被发现。相关研究表明Klotho蛋白可参与多种肾脏疾病的发生发展,其中Klotho与急性肾损伤(acute kidney injury, AKI)的诊治密切相关,不仅有望成为AKI早期诊断的生物标志物,甚至有望成为其治疗靶点。现就Klotho蛋白在AKI诊治中的研究进展进行详细阐述。

关键词: Klotho, 急性肾损伤, 抗炎, 抗氧化, 抗凋亡, 自噬

Abstract: Klotho gene was originally thought to be an anti-aging gene.In recent years, its’ anti-inflammatory response, anti-oxidative stress, anti-apoptosis, regulation of tissue autophagy, calcium and phosphorus metabolism and other functions have been gradually discovered.Related studies have shown that Klotho can participate in the occurrence and development of a variety of kidney diseases, among which Klotho is closely related to the diagnosis and treatment of acute kidney injury(AKI), which is expected to become not only a biomarker for early diagnosis of AKI, but also a therapeutic target.This article reviews the research progress of Klotho in the diagnosis and treatment of AKI in detali.

Key words: Klotho, acute kidney injury, anti-inflammatory, antioxidant, resistance to apoptosis, autophagy

中图分类号:

R692.5

张思, 张海松, 李叶, 王倩, 高燕. Klotho蛋白在急性肾损伤诊治中的研究进展[J]. 医学研究与教育, 2021, 38(2): 14-20.

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