细胞自噬与肿瘤、感染和免疫耐受

doi:10.3969/j.issn.1674-490X.2011.01.019

医学研究与教育 ›› 2011, Vol. 28 ›› Issue (1): 65-69.DOI: 10.3969/j.issn.1674-490X.2011.01.019

细胞自噬与肿瘤、感染和免疫耐受

孟明,李春晓,洪洋

河北大学基础医学院,河北保定,071000

收稿日期:2016-10-09 修回日期:2016-10-09 出版日期:2011-02-25 发布日期:2011-02-25

The relationship between autophagy and tumor, infection and immunological tolerance

MENG Ming,LI Chunxiao,HONG Yang

Received:2016-10-09 Revised:2016-10-09 Online:2011-02-25 Published:2011-02-25

摘要/Abstract

摘要： 细胞自噬是广泛存在于真核生物中的古老生命现象.其主要作用是细胞清除或降解自身受损的细胞器和多余的生物大分子,利用降解产物提供能量并重建细胞结构,以维持代谢平衡和内环境稳态.自噬不仅在细胞的正常生长、发育、衰老、死亡过程中起关键作用,而且与肿瘤及神经退行性疾病的形成及预后、胞内病原体感染的结局以及机体自身免疫耐受的形成关系密切.通过研究和利用自噬机制,可以发展新的临床治疗方法.

关键词: 自噬, 肿瘤, 胞内病原体, 自身免疫耐受

中图分类号:

R392

孟明,李春晓,洪洋. 细胞自噬与肿瘤、感染和免疫耐受[J]. 医学研究与教育, 2011, 28(1): 65-69.

MENG Ming,LI Chunxiao,HONG Yang. The relationship between autophagy and tumor, infection and immunological tolerance[J]. Medical Reserch and Education, 2011, 28(1): 65-69.

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细胞自噬与肿瘤、感染和免疫耐受

The relationship between autophagy and tumor, infection and immunological tolerance

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