缺血性脑卒中后抑郁的发病机制及新生物学指标

doi:10.3969/j.issn.1674-490X.2023.02.003

摘要/Abstract

摘要： 缺血性脑卒中后抑郁是缺血性脑卒中疾病发生后最常见的精神系统疾病之一,严重影响患者预后,延长住院时长、妨碍回归社会及家庭、降低生活质量,还可增加脑血管疾病再发的风险。缺血性脑卒中后抑郁发病原因复杂多样,目前发病机制不明确,诊断不及时,治疗效果不明显。为早期诊断、有效治疗、改善患者预后,需更详细研究缺血性脑卒中后抑郁发病机制,寻找新生物学指标。

关键词: 缺血性脑卒中后抑郁, 发病机制, 巨噬细胞炎性蛋白-1α, 高迁移率族蛋白B1

Abstract: Post-ischemic stroke depression is one of the most common psychiatric diseases after ischemic stroke, which seriously affects the prognosis of patients, prolongs the length of hospital stay, hinders social and family return, and reduces the quality of life. It can also increase the recurrence of cerebrovascular disease risk of occurrence. The pathogenesis of post-ischemic stroke depression is complex and diverse. At present, the pathogenesis is not clear, the diagnosis is not timely, and the treatment effect is not obvious. For early diagnosis, effective treatment, and improvement of the prognosis of patients, it is necessary for us to study the pathogenesis of ischemic post-stroke depression in more detail and find new biological indicators.

Key words: post-ischemic stroke depression, pathogenesis, macrophage inflammatory protein-1α, high mobility group box protein B1

中图分类号:

房翠,王秀丽,李玲钰,史福平. 缺血性脑卒中后抑郁的发病机制及新生物学指标[J]. 医学研究与教育, 2023, 40(2): 18-24.

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