Advance on the relationship between COX-2 and gastric cancer

doi:10.3969/j.issn.1674-490X.2013.05.022

Abstract

Abstract: Cyclooxygenase (COX) was the rate-limiting enzyme of the arachidonic acid synthesis of prostaglandins, which had a twofold activity of cyclooxygenase and peroxidase, now it had been confirmed there were two isozymes:COX-1 and COX-2. COX-2 was seen as“rapid response gene”, which was speciifc high expression in gastric cancer, and it was involved in gastric blood vessels, lymphatic formation, inhibition of apoptosis, inhibition of tumor imunity, promoting tumor metastasis, inifltration. Thus, it played an important role in the development of gastric cancer.

Key words: cyclooxygenase, gastric cancer, cyclooxygenase-2

CLC Number:

R735

YANG Nan,FENG Yichao. Advance on the relationship between COX-2 and gastric cancer[J]. Medical Reserch and Education, 2013, 30(5): 83-86,91.

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