Distribution and biological function of endothelin receptors

doi:10.3969/j.issn.1674-490X.2014.03.020

Abstract

Abstract: Endothelins (ETs) are composed of 21-aminoacids produced by endothelial cells and considered to be potent vasoconstrictor. Recent studies found that they could not only induce the angiogenesis, mitosis and differentiation, but also act the role of cytokines. Previous studies have identiifed three isoforms of ET (ET-1, ET-2 and ET-3), which are involved in a variety of physiological and pathological processes. ET-1 is most potent one among ETs, whereas ET-3 is the weakest once. ET peptides exhibit their functions in a number of mammalian physiological systems, including gastrointestinal. ETs act via two distinct isoforms of receptors in human body, i.e. endothelin receptor A (ETA) and endothelin receptor B (ETB), which can be found expressed in many mammalian cardiovascular system, neural system and gastrointestinal tract. ETA and ETB have same signaling pathways. And at the meantime, ETB can promote the activation of PLA2. The study also found that endothelins were widely associated with benign and malignant diseases.

Key words: endothelin, receptors, distribution, biological function

CLC Number:

R473

ZHANG Ke,CHEN Queting,WANG Xiaodong,ZHANG Yue,LI Tingting,SHI Lin. Distribution and biological function of endothelin receptors[J]. Medical Reserch and Education, 2014, 31(3): 76-81.

References

[1] ROCKEY D. The cellular pathogenesis of portal hypertension:stellate cell contractility, endothelin, and nitric oxide [J]. HEPATOLOGY 2007, 25(05).
[2] NUSSDORFER G G, ROSSI G P, MALENDOWICZ L K. Autocrine-paracrine endothelin system in the physiology and pathology ofsteroid-secreting tissues [J]. Pharmacological Reviews 2012, 54(11).
[3] Davenport AP. International Union of Pharmacology. XXIX. Update on Endothelin Receptor Nomenclature. [J]. Pharmacological reviews 2002, 2(2).
[4] NELSON J, BAGNATO A, BATTISTINI B. The endothelin axis:emerging role in cancer [J]. Nature Reviews Cancer 2003, 3(02).
[5] Khodorova A, Montmayeur JP, Strichartz G. [J]. The journal of pain: official journal of the American Pain Society 2009.
[6] Yanagisawa H, Yanagisawa M, Kapur RP, Richardson JA, Williams SC, Clouthier DE, de-Wit D, Emoto N, Hammer RE. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. [J]. Development 1998, 5(5).
[7] HUBLOUE I, BIARENT D, ABDEL KAFI S. Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction [J]. European Respiratory Journal 2013, 21(08).
[8] Evans RG, Bergstrom G, Cotterill E, Anderson WP. Renal haemodynamic effects of endothelin-1 and the ETA/ETB antagonist TAK-044 in anaesthetized rabbits. [J]. Journal of hypertension 1998, 12 Pt.2(12 Pt.2).
[9] BOHM F, PERNOW J, LINDSTROM J. ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic and renal circulation of healthy men [J]. CLINICAL SCIENCE 2003, 104(04).
[10] Tycho Vuurmans JL, Boer P, Koomans HA. [J]. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association 2004.
[11] OTA S, HIRATA Y, SUGIMOTO T. Endothelin-1 secretion from cultured rabbit gastric epithelial cells [J]. Journal of Cardiovascular Pharmacology 1991, 17(03).
[12] OLSEN U B, WEIS J. Rat gastric relaxation induced by stimulation of endothelin-1 selective receptors [J]. Regulatory Peptides 1992, 39(11).
[13] ALLCOCK G H, BATTISTINI B, FOURNIER A, el al. Characterization of endothelin receptors mediating mechanical responses to the endothelins in the isolated stomach strip of the rat [J]. Journal of Pharmacology and Experimental Therapeutics 1995, 275(07).
[14] Koepp Janice, Cardozo AlcibiaM, D'Orleans-Juste Pedro, Rae GilesA. Influence of indomethacin on effects of endothelin-1 on guinea pig isolated rings of common bile duct and sphincter of Oddi. [J]. European Journal of Pharmacology: An International Journal 2002, 1(1).
[15] Huang SC, Lee MC, Wei CK, Huang SM. Endothelin receptors in human and guinea-pig gallbladder muscle. [J]. Regulatory Peptides: An International Journal 2001, 3(3).
[16] Okabe H, Chijiiwa Y, Nakamura K, Yoshinaga M, Akiho H, Harada N, Nawata H. Two endothelin receptors (ETA and ETB) expressed on circular smooth muscle cells of guinea pig cecum. [J]. Gastroenterology 1995, 1(1).
[17] YOSHINAGA M, CHIJIIWA Y, MISAWA T. Endothelin B receptor on guinea pig small intestinal smooth muscle cells [J]. American Journal of Physiology 1992, 262(09).
[18] KITSUKAWA Y, GU Z F, HILDEBRAND P. Gastric smooth muscle cells possess two classes of endothelin receptors but only one alters contraction [J]. American Journal of Physiology 1994, 266(10).
[19] ALLCOCK G H, BATTISTINI B, FOURNIER A. Characterization of endothelin receptors mediating mechanical responses to the endothelins in the isolated stomach strip of the rat [J]. Journal of Pharmacology and Experimental Therapeutics 1995, 275(02).
[20] Uchida, K, Yuzuki, R, Kamikawa, Y. Pharmacological characterization of endothelin-induced contraction in the guinea-pig oesophageal muscularis mucosae. [J]. British Journal of Pharmacology 1998, 4(4).
[21] Huang SC. [J]. Regulatory Peptides: An International Journal 2005.
[22] Shih-Che Huang. [J]. Current Protein and Peptide Science 2005.
[23] JIANG Y F, JIA R P. Endotheline, endotheline receptor antagonist and homone refractory prostate cancer [J]. Int J of Urol and Nephrol 2006, 269(02).
[24] Neylon CB. [J]. Clinical and experimental pharmacology & physiology 1999.
[25] CHEN C, WAGONER P K. Endothelin induces a nonselective cation current in vascular smooth muscle cells [J]. CIRCULATION RESEARCH 1991, 69(07).
[26] GRINSTEIN S, ROTHSTEIN A. Mechanisms of regulation of the Na+/H+exchanger [J]. Journal of Membrane Biology 1986, 90(11).
[27] KOH E, MORIMOTO S, KIM S, NABATA T. Endothelin stimulates Na+/H+exchange in vascular smooth muscle cells [J]. Biochemistry International 2010, 20(07).
[28] LONCHAMPT M O, PINELIS S, GOULIN J. Proliferation and Na+/H+exchange activation by endothelin in vascular smooth muscle cells [J]. American Journal of Hypertension 1991, 4(01).
[29] NEWTON A C, KERANEN L M. Phosphatidyl-l-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-contain-ing membranes [J]. Biochemistry 2004, 33(05).
[30] CLERK A, BOGOYEVITCH M A, ANDERSON M B. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts [J]. Journal of Biological Chemistry 2004, 269(12).
[31] SIMONSON M S, WANG Y, HERMAN W H. Ca2+channels mediate protein tyrosine kinase activation by endothelin-1 [J]. American Journal of Physiology 1996, 270(04).
[32] ZAMORA M R, DEMPSEY E C, WALCHAK S J. BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells [J]. American Journal of Respiratory Cell and Molecular Biology 2013, 9(08).
[33] Clerk A, Kemp TJ, Harrison JG, Mullen AJ, Barton PJR, Sugden PH. Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein [J]. The Biochemical Journal 2002, 0(0).
[34] BARTON M. Reversal of proteinuric Fellal disease and the enlerging role of endothelin [J]. NEPHROLOGY 2008, 4(09).
[35] Caligiuri G, Levy B, Pernow J, Thoren P, Hansson GK. [J]. Proceedings of the National Academy of Sciences of the United States of America 1999.
[36] AHMED S I, THOMPS0U J, COULS0N J M. Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium [J]. Am J Resp Cell Mol Biol 2012, 22(04).