doi:10.3969/j.issn.1674-490X.2020.01.008

Abstract

Abstract: Objective To study the correlation between the level of thyroid stimulating hormone(TSH)and the severity of coronary artery disease in patients with subclinical hypothyroidism(SCH).Methods 246 patients with coronary heart disease diagnosed by coronary angiography, according to the level of serum TSH, were selected and divided into subclinical hypothyroidism group(126 patients)and normal nail function group(120 patients), and the SYNTAX score of coronary artery disease in subclinical hypothyroidism group was calculated. Spearman was used to analyze the correlation between TSH level and severity of coronary artery disease. Results There was no significant difference in age, sex, smoking history, prevalence of hypertension, systolic blood pressure and diastolic blood pressure between subclinical hypothyroidism group and normal group(P>0.05).The TSH,TC, TG, LDL-C, AIP in subclinical hypothyroidism group were higher than those in normal group, the difference was statistically significant(P<0.05). The TSH, TC, TG, LDL-C, AIP were higher than middle group and low group、middle group were higher than low group in subclinical hypothyroidism group, the difference was statistically significant(P<0.05). Spearman correlation analysis showed that TSH was positively correlated with SYNTAX score(r=0.768, P<0.001). Conclusion The increase of TSH at subclinical level is one of the risk factors of coronary heart disease, and has a positive correlation with the severity of coronary artery disease.

Key words: coronary heart disease, subclinical hypothyroidism, SYNTAX score, plasma arteriosclerosis index

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References

[1] DECANDIA F. Risk factors for cardiovascular disease in subclinical hypothyroidism[J]. Ir J Med Sci, 2018, 187(1): 39-43. DOI: 10.1007/s11845-017-1617-9.
[2] 杨军, 王光辉, 丁赛良, 等. 血清瘦素水平与冠心病危险分层及冠脉病变程度的相关性[J]. 重庆医学, 2014, 43(2): 158-160. DOI: 10.3969/j.issn.1671-8348.2014.02.011.
[3] CAI G, LIU W, LV S, et al. Gender-specific associations between atherogenic index of plasma and the presence and severity of acute coronary syndrome in very young adults: a hospital-based observational study[J]. Lipids Health Dis, 2019, 18: 99. DOI: 10.1186/s12944-019-1043-2.
[4] HUSSAIN A, ELMAHDAWI A M, ELZERAIDI N E, et al. The effects of dyslipidemia in subclinical hypothyroidism[J]. Cureus, 2019, 11(11): e6173. DOI: 10.7759/cureus.6173.
[5] VAN TIENHOVEN-WIND L J, DULLAART R P. Low-normal thyroid function and the pathogenesis of common cardio-metabolic disorders[J]. Eur J Clin Invest, 2015, 45(5): 494-503. DOI: 10.1111/eci.12423.
[6] SARIC M S, JURASIC M J, SOVIC S, et al. Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol(sdLDL-C)[J]. Rom J Intern Med, 2017, 55(3): 159-166. DOI: 10.1515/rjim-2017-0015.
[7] JAMES S R, RAY L, RAVICHANDRAN K, et al. High atherogenic index of plasma in subclinical hypothyroidism: Implications in assessment of cardiovascular disease risk[J]. Indian J Endocrinol Metab, 2016, 20(5): 656-661. DOI: 10.4103/2230-8210.190550.
[8] 田刚, 南岳, 孙中华, 等. 亚临床甲状腺功能减退症与冠心病相关性因素的研究进展[J]. 山东医药, 2013, 53(32): 83-85. DOI: 10.3969/j.issn.1002-266X.2013.32.036.
[9] 苗莉, 丁瑾, 严庭智, 等. 亚临床甲状腺功能减退症合并心血管疾病患者的临床特征分析[J]. 天津医药, 2016, 44(11): 1308-1310. DOI: 10.11958/20161136.
[10] YILDIZ G, CANDAN F, KAYATAS M, et al. The mean platelet volume and atherogenic index of plasma in nondipper normotensive individuals compared to dippers[J]. Clin Exp Hypertens, 2013, 35(1):35-39. DOI: 10.3109/10641963.2012.689043.
[11] SCHIELE F, FARNIER M, KREMPF M, et al. A consensus statement on lipid management after acute coronary syndrome[J]. Eur Heart J Acute Cardiovasc Care, 2018, 7(6): 532-543. DOI: 10.1177/2048872616679791.
[12] GITT A K, LAUTSCH D, FERRIÈRES J, et al. Contemporary data on treatment practices for low-density lipoprotein cholesterol in 3867 patients who had suffered an acute coronary syndrome across the world[J]. Data Brief, 2017, 16: 369-375. DOI: 10.1016/j.dib.2017.11.034.
[13] FUJISUE K, TSUJITA K. Current status of lipid management in acute coronary syndrome[J]. J Cardiol, 2017, 70(2): 101-106. DOI: 10.1016/j.jjcc.2017.02.004.
[14] 姚艳妮, 胡越成, 丛洪良. SYNTAX评分及其衍生评分的研究进展[J]. 中华心血管病杂志, 2017, 45(4): 341-344. DOI: 10.3760/cma.j.issn.0253-3758.2017.04.019.
[15] 李张曼玉, 李晓盼, 于莹, 等. 血浆致动脉硬化指数与冠状动脉病变严重程度的相关性研究[J]. 中国介入心脏病学杂志, 2019, 27(2): 107-110. DOI: 10.3969/j.issn.1004-8812.2019.02.008.

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[4]	. [J]. Medical Reserch and Education, 2017, 34(1): 39-43.
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