doi:10.3969/j.issn.1674-490X.2020.05.001

Abstract

Abstract: Objective To analyze the potential molecular mechanism of coronary heart disease induced by biorhythm disorder. Methods GSE71226 dataset was downloaded from Gene Expression Omnibus(GEO). R software was used to identify coronary heart disease differentially expressed genes(CHD-DEGs), through text mining and protein interaction analysis, biological clock related genes(BRGs)were obtained, and functional annotation, chromosome location and interaction analysis were carried out. Results 488 CHD-DEGs and 64 BRGs were obtained, which densely distributed on chromosomes, mostly related to transcription regulation, inflammation and immune system diseases. Among them, 28 CHD-DEGs interacted significantly with 22 BRGs, and there were 10 important associated target genes. Conclusion Biological rhythm disorder is closely related to the occurrence of coronary heart disease.

Key words: biological clock, coronary heart disease, bioinformatics, chromosome location, enrichment analysis

CLC Number:

R392

References

[1] TORMEY D, COLBOURNE J K, MOCKAITIS K, et al. Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii[J]. BMC Genom, 2015, 16: 754. DOI: 10.1186/s12864-015-1937-y.
[2] MASRI S, CERVANTES M, SASSONE-CORSI P. The circadian clock and cell cycle: interconnected biological circuits[J]. Curr Opin Cell Biol, 2013,25(6):730-734. DOI: 10.1016/j.ceb.2013.07.013.
[3] PEREIRA L R, MOREIRA F P, REYES A N, et al. Biological rhythm disruption associated with obesity in school children[J]. Child Obes, 2019, 15(3): 200-205. DOI: 10.1089/chi.2018.0212.
[4] HONG W, ZHANG Q T. Biological rhythms advance in depressive disorder[M] //FANG Y R.Advances in Experimental Medicine and Biology. Singapore: Springer Singapore, 2019: 117-133. DOI: 10.1007/978-981-32-9271-0_6.
[5] HOMOLAK J, MUDROVC ˇIC ' M, VUKIC ' B, et al. Circadian rhythm and Alzheimer's disease[J]. Med Sci, 2018, 6(3): 52. DOI: 10.3390/medsci6030052.
[6] DAVIS K, RODEN L C, LEANER V D, et al. The tumour suppressing role of the circadian clock[J]. IUBMB Life, 2019, 71(7): 771-780. DOI: 10.1002/iub.2005.
[7] MORRIS C J,YANG J N,SCHEER F A J L. The impact of the circadian timing system on cardiovascular and metabolic function[J].Prog Brain Res,2012,199:337-358. DOI: 10.1016/B978-0-444-59427-3.00019-8.
[8] HERRINGTON W, LACEY B, SHERLIKER P, et al. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease[J]. Circ Res, 2016, 118(4): 535-546. DOI: 10.1161/circresaha.115.307611.
[9] FAWZY M S, TORAIH E A, ALY N M, et al. Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study[J]. BMC Cardiovasc Disord, 2017, 17: 26. DOI: 10.1186/s12872-016-0456-3.
[10] ESCOBAR E. Hypertension and coronary heart disease[J]. J Hum Hypertens, 2002, 16(S1): S61-S63. DOI: 10.1038/sj.jhh.1001345.
[11] NORDENSKJÖLD A M, EGGERS K M, JERNBERG T, et al. Circadian onset and prognosis of myocardial infarction with non-obstructive coronary arteries(MINOCA)[J]. PLoS One, 2019, 14(4): e0216073. DOI: 10.1371/journal.pone.0216073.
[12] WEI Z L, LIU Y H, QIAO S H, et al. Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: an investigation based on GEO and TCGA databases[J]. Oncol Lett, 2019, 17(6):5409-5418. DOI: 10.3892/ol.2019.10232.
[13] LEE K Y, AHN Y M, KIM S H, et al. Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics[J]. Nord J Psychiatry, 2018, 72(8): 599-604. DOI: 10.1080/08039488.2018.1509125.
[14] LAVTAR P, RUDOLF G, MAVER A, et al. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis[J]. PLoS One, 2018, 13(1): e0190601. DOI: 10.1371/journal.pone.0190601.
[15] QIU M J, LIU L P, JIN S, et al. Research on circadian clock genes in common abdominal malignant tumors[J]. Chronobiol Int, 2019,36(7):906-918. DOI: 10.1080/07420528.2018.1477792.
[16] PRZYBYŁA P, SHARDLOW M, AUBIN S, et al. Text mining resources for the life sciences[J]. Database, 2016, 25: baw145. DOI: 10.1093/database/baw145.
[17] ATHANASIOS A, CHARALAMPOS V, VASILEIOS T, et al. Protein-protein interaction(PPI)network: recent advances in drug discovery[J]. Curr Drug Metab, 2017, 18(1): 5-10. DOI: 10.2174/138920021801170119204832.
[18] THOMAS P D. The gene ontology and the meaning of biological function[M] //DESSIMOZ C.Methods in Molecular Biology. New York: Springer New York, 2016: 15-24. DOI: 10.1007/978-1-4939-3743-1_2.
[19] STELZER G, ROSEN N, PLASCHKES I, et al. The genecards suite: from gene data mining to disease genome sequence analyses[J]. Curr Protoc Bioinformatics, 2016,54:1-33. DOI: 10.1002/cpbi.5.
[20] SZKLARCZYK D, GABLE A L, LYON D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets[J]. Nucleic Acids Res, 2019, 47(D1): D607-D613. DOI: 10.1093/nar/gky1131.
[21] HUANG D W, SHERMAN B T, TAN Q N, et al. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists[J]. Nucleic Acids Res, 2007, 35(S2): W169-W175. DOI: 10.1093/nar/gkm415.
[22] SPOHR P, DINKLA K, KLAU G W, et al. eXamine: visualizing annotated networks in Cytoscape[J]. F1000Res, 2018, 7: 519. DOI: 10.12688/f1000research.14612.2.
[23] HAEUSSLER M, ZWEIG A S, TYNER C, et al. The UCSC genome browser database, 2019 update[J].Nucleic Acids Res, 2019,47(D1):D853-D858. DOI: 10.1093/nar/gky1095.
[24] CHAO J T, KONG Y Z, WANG Q, et al. MapGene2Chrom, a tool to draw gene physical map based on Perl and SVG languages[J].Yi Chuan, 2015, 37(1):91-97. DOI: 10.16288/j.yczz.2015.01.013.
[25] BARRETT T. NCBI GEO: mining millions of expression profiles: database and tools[J]. Nucleic Acids Res, 2004, 33(Database issue): D562-D566. DOI: 10.1093/nar/gki022.
[26] CRNKO S, DU PRÉ B C, SLUIJTER J P G, et al. Circadian rhythms and the molecular clock in cardiovascular biology and disease[J]. Nat Rev Cardiol, 2019, 16(7): 437-447. DOI: 10.1038/s41569-019-0167-4.
[27] STEFFENS S, WINTER C, SCHLOSS M J, et al. Circadian control of inflammatory processes in atherosclerosis and its complications[J]. Arterioscler Thromb Vasc Biol, 2017, 37(6): 1022-1028. DOI: 10.1161/atvbaha.117.309374.
[28] CHOJNACKI M, ZHANG D N, TALAROWSKA M, et al. Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB⁺¹[J]. FEBS Lett, 2016, 590(24): 4573-4585. DOI: 10.1002/1873-3468.12484.
[29] 古联, 黎同顺, 李敏华,等. EP300基因rs20551多态性与缺血性脑卒中痰瘀证和冠心病痰瘀证及其凝血功能的关联研究[J].中华老年心脑血管病杂志,2019,21(7):720-724.DOI: 10.3969/j.issn.1009-0126.2019.07.012.
[30] 陈梦, 余亚莉, 曹楠, 等. 炎症性肠病中CXCL10组蛋白H3K27ac修饰变化研究[J].临床消化病杂志,2019,31(5): 298-303.DOI: 10.3870/lcxh.j.issn.1005-541X.2019.05.07.
[31] WANG E J, CHEN X, YU X B, et al. Degradation of CCNB1 mediated by APC11 through UBA52 ubiquitination promotes cell cycle progression and proliferation of non-small cell lung cancer cells[J]. Am J Transl Res, 2019, 11(11): 7166-7185.
[32] NEILSEN B K, FRODYMA D E, MCCALL J L, et al. ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells[J]. PLoS One, 2019, 14(1): e0209224. DOI: 10.1371/journal.pone.0209224.
[33] ZHANG J S, YUAN P, YAN Z Y, et al. Timeless promotes the proliferation of hepatocellular carcinoma cell by reprogramming of glucose metabolism[J].Zhonghua Zhong Liu Za Zhi,2018,40(7):499-505. DOI: 10.3760/cma.j.issn.0253-3766.2018.07.004.
[34] ZHANG W J, HE W L, SHI Y J, et al. Aberrant TIMELESS expression is associated with poor clinical survival and lymph node metastasis in early-stage cervical carcinoma[J]. Int J Oncol, 2017, 50(1): 173-184. DOI: 10.3892/ijo.2016.3784.
[35] LIU D, ZHANG X X, XI B X, et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer[J]. Int J Oncol, 2014, 45(3): 1232-1240. DOI: 10.3892/ijo.2014.2510.
[36] KAUR G, BALASUBRAMANIAM S D, LEE Y J, et al. Minichromosome maintenance complex(MCM)genes profiling and MCM2 protein expression in cervical cancer development[J]. Asian Pac J Cancer Prev, 2019, 20(10): 3043-3049. DOI: 10.31557/apjcp.2019.20.10.3043.
[37] KIM H I, LEE H J, CHO C H, et al. Association of CLOCK, ARNTL, and NPAS2 gene polymorphisms and seasonal variations in mood and behavior[J]. Chronobiol Int, 2015, 32(6): 785-791. DOI: 10.3109/07420528.2015.1049613.
[38] SONG H M, CHO C H, LEE H J, et al. Association of CLOCK, ARNTL, PER2, and GNB3 polymorphisms with diurnal preference in a Korean population[J]. Chronobiol Int, 2016, 33(10): 1455-1463. DOI: 10.1080/07420528.2016.1231199.
[39] HODZ ˇIC ' A, RISTANOVIC ' M, ZORN B, et al. Genetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertility[J]. PLoS One, 2013, 8(3): e59220. DOI: 10.1371/journal.pone.0059220.
[40] BERING T, CARSTENSEN M B, WÖRTWEIN G, et al. The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl Clock gene in cortical neurons[J]. Cereb Cortex, 2018, 28(2): 644-657. DOI: 10.1093/cercor/bhw406.
[41] SHIN S, WOLGAMOTT L, ROUX P P, et al. Casein kinase 1 promotes cell proliferation by regulating mRNA translation[J]. Cancer Res, 2014, 74(1): 201-211. DOI: 10.1158/0008-5472.can-13-1175.
[42] ZHENG X, SOWCIK M, CHEN D, et al. Casein kinase 1 promotes synchrony of the circadian clock network[J]. Mol Cell Biol, 2014, 34(14): 2682-2694. DOI: 10.1128/mcb.01571-13.
[43] YU Y M, LI Y H, ZHOU L, et al. Cryptochrome 2(CRY2)suppresses proliferation and migration and regulated clock gene network in osteosarcoma cells[J].Med Sci Monit, 2018, 24:3856-3862. DOI: 10.12659/MSM.908596.
[44] KISHI S, BROOKS C R, TAGUCHI K, et al. Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses[J]. J Clin Investig, 2019, 129(11): 4797-4816. DOI: 10.1172/jci122313.
[45] LIANG J, WANG W F, XIE S, et al. Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis[J]. Oncol Lett, 2015, 9(6): 2651-2656. DOI: 10.3892/ol.2015.3113.
[46] TAKEDA N, MAEMURA K. Circadian clock and cardiovascular disease[J]. J Cardiol, 2011, 57(3): 249-256. DOI: 10.1016/j.jjcc.2011.02.006.
[47] MAEMURA K, TAKEDA N, NAGAI R. Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases[J]. J Pharmacol Sci, 2007, 103(2): 134-138. DOI: 10.1254/jphs.fmj06003x2.
[48] WANG D F, CHEN S Y, LIU M, et al. Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver[J]. Chronobiol Int, 2015, 32(5): 615-626. DOI: 10.3109/07420528.2015.1025958.
[49] FIORANELLI M, BOTTACCIOLI A G, BOTTACCIOLI F, et al. Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based[J]. Front Immunol, 2018, 9: 2031. DOI: 10.3389/fimmu.2018.02031.
[50] VIJAY K. Toll-like receptors in immunity and inflammatory diseases: past, present, and future[J]. Int Immunopharmacol, 2018, 59: 391-412. DOI: 10.1016/j.intimp.2018.03.002.
[51] COCHET F, PERI F. The role of carbohydrates in the lipopolysaccharide(LPS)/toll-like receptor 4(TLR4)signalling[J]. Int J Mol Sci, 2017, 18(11): 2318. DOI: 10.3390/ijms18112318.
[52] ROY A, SRIVASTAVA M, SAQIB U, et al. Potential therapeutic targets for inflammation in toll-like receptor 4(TLR4)-mediated signaling pathways[J]. Int Immunopharmacol, 2016, 40: 79-89. DOI: 10.1016/j.intimp.2016.08.026.
[53] GISTERÅ A, HANSSON G K. The immunology of atherosclerosis[J]. Nat Rev Nephrol, 2017, 13(6): 368-380. DOI: 10.1038/nrneph.2017.51.
[54] HEIPERTZ E L, HARPER J, LOPEZ C A, et al. Circadian rhythms influence the severity of Sepsis in mice via a TLR2-dependent, leukocyte-intrinsic mechanism[J]. J Immunol, 2018, 201(1): 193-201. DOI: 10.4049/jimmunol.1701677.

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