Abstract: Objective To explore the effect of early inhalation of budesonide on lung function, osteopontin and α-SMA in asthmatic animals. Methods Sixty male SD rats were randomly divided into control group, model group and treatment group. The model group and the treatment group were prepared by intraperitoneal injection of ovalbumin and repeated aerosol inhalation of ovalbumin, and the control animals were treated with physiological saline. Changes in lung function, osteopontin, and α-SMA were measured in three groups of animals. Results Compared with the control group, the basic airway resistance and airway responsiveness increased in the model group and the treatment group. The basic airway resistance and airway responsiveness in the treatment group were better than those in the model group. The expression of osteopontin and airway α-SMA in the model group and the treatment group was significantly higher than that in the control group. The expression of the above indicators in the treatment group was lower than that in the model group. The expression of osteopontin was positively correlated with airway resistance, and it was also positively correlated with the expression of α-SMA. Conclusion Early inhalation of budesonide is beneficial to improve lung function and reduce airway remodeling in asthma, and its mechanism may be related to the regulation of osteopontin.

Key words: asthma, budesonide, lung function, osteopontin, α-smooth muscle actin(α-SMA)