Abstract: Objective To investigate expression of osteopontin (OPN) and adhesion molecule CD44v6 in colon adenocarcinoma and their clinical signiifcance. Methods 80 cases of colon cancer tissue were detected by immunohistochemical methods (with lymph node metastasis in 32 cases, 48 cases without lymph node metastasis), 30 cases of colorectal adenoma, 20 cases from colon tumor (polyp, adenoma, cancer, etc.) 5 cm above normal tissue osteopontin and CD44v6 expression levels were examined to analyze the correlation of osteopontin and CD44v6 expression in colon adenocarcinoma. Results Adenocarcinoma of the colon and surrounding lymph nodes, osteopontin and CD44v6 expression were signiifcantly higher than that of normal colon tissue and colonic adenoma expression levels (P<0.05), colon adenocarcinoma with metastasis in osteopontin CD44v6 protein expression levels were significantly higher than that of non-metastatic colon adenocarcinoma (P<0.05). Colon adenocarcinoma osteopontin expression and expression of CD44v6 were in a state of consistency (P<0.05). Conclusion OPN-CD44v6 with colon adenocarcinoma, developing consistent, osteopontin and CD44v6 joint detection for colon cancer development and prognosis explicitly provide a basis for clinical diagnosis and treatment , which has a certain signiifcance in clinical practices.

Key words: colon adenocarcinoma, tumor metastasis, osteopontin, CD44v6, immunohistochemistry