Abstract: Objective To explore the clinical effect of laparoscopic colorectal cancer natural orifice specimen extraction surgery(NOSES)in the treatment of colorectal cancer, as well as the effect on oxidative stress and inflammatory response of patients. Methods 134 patients with colorectal cancer who received surgical treatment in our hospital from March 2018 to November 2019 were divided into two groups according to different surgical procedures. Among them, 67 patients in the observation group received laparoscopic NOSES operation, 67 patients in the control group received laparoscopic colorectal cancer radical surgery. After treatment, the operation related indicators, oxidative stress and inflammatory response were compared between the two groups. Results The first exhaust time and postoperative hospitalization time of the observation group were(26.32±3.13)h and(6.62±0.77)d, respectively, which were significantly lower than those of the control group, with statistical difference(P<0.05). The MDA and SOD levels of the two groups were significantly higher and lower 24 hours after operation, and the MDA and SOD levels of the observation group were significantly lower than those of the control group, with statistical difference(P<0.05). 24 hours after operation, the two groups The levels of TNF-α, CRP and IL-6 in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Laparoscopic NOSES can effectively improve oxidative stress and inflammation in patients with colorectal cancer, and the postoperative rehabilitation effect is significant, which is worthy of clinical application.

Key words: colorectal cancer, laparoscopy, natural orifice specimen extraction surgery, oxidative stress, inflammatory response