Developments on acute respiratory distress syndrome induced by sepsis

doi:10.3969/j.issn.1674-490X.2016.05.007

Abstract

Abstract: Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens.Acute respiratory distress syndrome(ARDS)is a devastating complication of severe sepsis,in which patients have high mortality.Advances in treatment modalities including lung protective ventilation,prone positioning,use of neuromuscular blockade,and extracorporeal membrane oxygenation,have improved the outcome over recent decades,nevertheless,the mortality rate still remains high.Timely treatment of underlying sepsis and early identification of patients at risk of ARDS can help to decrease its development.In addition,further studies are needed regarding pathogenesis and novel therapies in order to show promising future treatments of sepsis-induced ARDS.

Key words: sepsis, shock, acute respiratory distress syndrome

CLC Number:

R563.8

JU Hailong,ZHOU Yinglian,LIU Peng,ZHANG Xinxin,PENG Guangjun. Developments on acute respiratory distress syndrome induced by sepsis[J]. Medical Reserch and Education, 2016, 33(5): 30-34.

References

[1] MIKKELSEN M E,SHAH C V,MEYER N J,et al.The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis[J].Shock,2013,40(5):375-381.DOI: 10.1097/SHK.0b013e3182a64682.
[2] 北京市科委重大项目MODS课题组.1998-2003年北京地区重症加强治疗病房急性呼吸窘迫综合征的临床流行病学调查[J].中国危重病急救医学,2007,19(4):201-204.
[3] MENEZES S L,BOZZA P T,NETO H C,et al.Pulmonary and extrapulmonary acute lung injury: inflammatory and ultrastructural analyses[J].J Appl Physiol,2005,98(5):1777-1783.DOI:10.1152/japplphysiol.01182.2004.
[4] CALFEE C S,JANZ D R,BERNARD G R,et al.Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies[J].Chest,2015,147(6):1539-1548.DOI: 10.1378/chest.14-2454.
[5] FRAT J P,RAGOT S,THILLE A W.High-flow nasal cannula oxygen in respiratory failure[J].N Engl J Med,2015,373(14):1374-1375.DOI: 10.1056/NEJMc1508390.
[6] KANG B J,KOH Y,LIM C M,et al.Failure of high-flow nasal cannula therapy may delay intubation and increase mortality[J].Intensive Care Med,2015,41(4):623-632.DOI: 10.1007/s00134-015-3693-5.
[7] OH D K,LEE M G,CHOI E Y,et al.Low-tidal volume mechanical ventilation in patients with acute respiratory distress syndrome caused by pandemic influenza A/H1N1 infection[J].J Crit Care,2013,28(4):358-364.DOI: 10.1016/j.jcrc.2013.03.001.
[8] AMATO M B,MEADE M O,SLUTSKY A S,et al.Driving pressure and survival in the acute respiratory distress syndrome[J].N Engl J Med,2015,372(8):747-755.DOI: 10.1056/NEJMsa1410639.
[9] CALFEE C S,DELUCCHI K,PARSONS P E,et al.Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials[J].Lancet Respir Med,2014,2(8):611-620.DOI: 10.1016/S2213-2600(14)70097-9.
[10] MERCAT A,RICHARD J C,VIELLE B,et al.Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial[J].JAMA,2008,299(6):646-655.DOI: 10.1001/jama.299.6.646.
[11] GUERIN C,REIGNIER J,RICHARD J C,et al.Prone positioning in the acute respiratory distress syndrome[J].N Engl J Med,2013,369(10):980-981.DOI: 10.1056/NEJMc1308895.
[12] SLUTSKY A S,RANIERI V M.Ventilator-induced lung injury[J].N Engl J Med,2013,369(22):2126-2136.DOI: 10.1056/NEJMc1400293.
[13] STEINGRUB J S,LAGU T,ROTHBERG M B,et al.Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis[J].Crit Care Med,2014,42(1):90-96.DOI: 10.1097/CCM.
[14] PEEK G J,MUGFORD M,TIRUVOIPATI R,et al.Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure(CESAR): a multicentre randomised controlled trial[J].Lancet,2009,374(9698):1351-1363.DOI: 10.1016/S0140-6736(09)61069-2.
[15] COMBES A,BRODIE D,BARTLETT R,et al.Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients[J].Am J Respir Crit Care Med,2014,190(5):488-496.DOI: 10.1164/rccm.
[16] CHO W H,LEE K,HUH J W,et al.Physiologic effect and safety of the pumpless extracorporeal interventional lung assist system in patients with acute respiratory failure-a pilot study[J].Artif Organs,2012,36(4):434-438.DOI: 10.1111/j.1525-1594.2011.01359.x.
[17] TAYLOR R W,ZIMMERMAN J L,DELLINGER R P,et al.Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial[J].JAMA,2004,291(13):1603-1609.
[18] GIRARD T D,KRESS J P,FUCHS B D,et al.Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care(Awakening and Breathing Controlled trial): a randomised controlled trial[J].Lancet,2008,371(9607):126-134.DOI: 10.1016/S0140-6736(08)60105-1.
[19] PRZYBYSZ T M,HEFFNER A C.Early Treatment of severe acute respiratory distress syndrome[J].Emerg Med Clin North Am,2016,34(1):1-14.DOI: 10.1016/j.emc.2015.08.001.
[20] ANNANE D,BELLISSANT E,BOLLAERT P E,et al.Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review [J].JAMA,2009,301(22):2362-2375.DOI: 10.1001/jama.2009.815.
[21] O'NEAL H R J r,KOYAMA T,KOEHLER E A,et al.Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome[J].Crit Care Med,2011,39(6):1343-1350.DOI: 10.1097/CCM.0b013e3182120992.
[22] CHANG Y,PARK S H,HUH J W,et al.Intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome[J].J Korean Med Sci,2014,29(3):438-440.DOI: 10.3346/jkms.2014.29.3.438.