Abstract: Platinum drugs are one of the most effective chemotherapy drugs for ovarian cancer, and although the initial response to platinum chemotherapy is as high as 80%, resistance is common. In most advanced patients, eventual relapse and death are caused by acquired resistance. Chemotherapy resistance of ovarian cancer is a major obstacle affecting its therapeutic effect. However, the cause of chemotherapy resistance is unclear and the mechanism is complex, which is a difficult and hot point in clinical and scientific research. Therefore, the study of drug resistance mechanism of ovarian cancer will provide a basis for the exploration and development of chemotherapy for ovarian cancer.This article reviews the molecular mechanism of platinum resistance in ovarian cancer.

Key words: ovarian cancer, platinum chemotherapy resistance, molecular mechanism

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