Abstract: In the context of the new era, there are numerous challenges in clinical skills teaching, such as system integration, adoption of new technologies, and shaping of individualization. Taking the Clinical Skills Experimental Teaching Center of Chongqing Medical University as an example, this article explores how it, as a national-level demonstration center, has undergone innovative development. The center has established a construction framework encompassing “three integrations” “four new technologies” and “five modernizations” as well as a development trend of “one platform and three centers”. It has achieved outstanding results in operational innovation, curriculum improvement, teaching reform, information technology creation, and student shaping. The innovative development emphasizes the in-depth application of new technologies such as artificial intelligence and virtual simulation, while also focuses on enhancing students' scientific thinking, innovation ability, and humanistic literacy. This demonstrates the strategic transformation and functional expansion of the Clinical Skills Center, providing a reference example for the high-quality and sustainable development of clinical skills experimental teaching centers.

Key words: experimental teaching of clinical skills, National Demonstration Center for Experimental Education, education reform, artificial intelligence, informationization