Abstract: Objective To study the protective effect of compound glycyrrhizin (CG) on hepatic injury Induced by Con A. Methods 50 mice of BALB/C species were randomly divided into normal group, model group, high, medium, low-dose CG-treated group (400, 200, 100 mg?kg-1?d-1), CG-treated group were injected into peritoneal cavity, the normal and model groups were given normal saline. After 7 days, beside mice in normal group, other groups were injected with concanavalin A (Con A) 20 mg/kg via the tail vein to damage mice’s liver. After 12 hour, the index of liver and spleen were calculated .Using automatic biochemical analyzer, the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were examined, using ELISA for determination of the serum cytokines:tumor necrosis factor alpha (TNF-α). Results Compared with model group, high, medium, low-dose CG-treated group could significantly decrease the activity of AST and ALT and the index of liver and spleen in mice, and CG also could significantly reduce the inflammatory cytokines TNF-αlevel. Conclusion CG is effective in protecting immunological liver injury in mice induced by Con A.

Key words: compound glycyrrhizin(CG), hepatic damage, concanavalin A