Abstract: Objective To study the inhibition activity and kinetics style of 6-fluorothiochromanone Mannich bases to acetylcholinesterase. Methods The inhibition and kinetics tests of 6-fluorothiochromanone Mannich bases to acetylcholinesterase were carried out by Ellman methods in vitro. Results The inhibition ratio of acetylcholinesterase was 51% when the concentration of this compound was 10-6mol/L, its inhibitive activity was better than Rivastigmine and primary kinetics experiments proved to be a mixed type of inhibition. conclusion 6-fluorothiochromanones Mannich bases are worthy for further research in acetylcholinesterase inhibitors.

Key words: thiochromanones, acetylcholinesterase inhibitors, Mannich bases, Alzheimer’s disease, kinetics