Table of Content

25 April 2013, Volume 30 Issue 2

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The implication of G-quadruplex in cancers and neurodegenerative diseases

2013, 30(2):  1-7. 

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In the last decade, translational medicine came into the limelight, aiming to bridge the gap between basic research and clinical application. The association of G-quadruplex with life-threating and debilitating diseases is an emerging topic in translational medicine. Since the formation of G-quadruplex can inhibit telomerase activity, the ligands that can stabilize G-quadruplex have great significance for cancer therapeutics. In addition, growing evidence suggests the implication of quadruplex in neurodegenerative diseases. In this review, the research of G-quadruplex in the fields of anti-tumor drugs and neurodegenerative diseases is discussed.

Study of 6-fluorothiochromanone Mannich bases inhibition activity and kinetics to acetylcholinesterase

2013, 30(2):  8-11. 

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Objective To study the inhibition activity and kinetics style of 6-fluorothiochromanone Mannich bases to acetylcholinesterase. Methods The inhibition and kinetics tests of 6-fluorothiochromanone Mannich bases to acetylcholinesterase were carried out by Ellman methods in vitro. Results The inhibition ratio of acetylcholinesterase was 51% when the concentration of this compound was 10-6mol/L, its inhibitive activity was better than Rivastigmine and primary kinetics experiments proved to be a mixed type of inhibition. conclusion 6-fluorothiochromanones Mannich bases are worthy for further research in acetylcholinesterase inhibitors.

Effects of simvastin on vascular elasticity and characterization of atherosclerotic plaque in rabbits with atherosclerosis

2013, 30(2):  12-15. 

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Abstrac: Objeetive To study the effects of simvastin on the characterization of plaque and vascular elasticity in rabbits with atherosclerosis. Methods 30 New Zealand rabbits were randomly divided into three groups. The rabbits in control group were given basic food, and the rabbits in model group were given aortic endothelium balloon injury and high lipid diet, and simvastin were given to the treatment group. After 10 weeks, the ratio of thickness of fibrous cap and the lipid core areas were obtained by pathological observation, and vascular elasticity were estimated with echo-tracking. Results The rabbits in model group had the less weak thickness of fibrous cap and the greater areas of lipid core than the treatment group. And the vascular elasticity in simvastin treatment group were better than that of the model group(P<0.05). The ratio of thickness of fibrous cap and the lipid core areas were negativly related to pressure-strain elasticity modulus (Eρ) and the stiffness parameter (β). conclusion Simvastin participate in the everlasting atherosclerosis vascular remodeling, with inhibiting inflammation, improving vascular endothelial function and changing the characterization of plaque.

Effects of dexrazoxane for paclitaxel-induced cardiotoxicity

2013, 30(2):  16-20. 

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Objective To study the effects of dexrazoxane in preventing paclitaxel-induced cardiotoxicity in rat models and its mechanism. Methods 64 Wistar rats were randomly divided into four groups: Control group, paclitaxel group, paclitaxel + small dose of dexrazoxane group, paclitaxel + large dose of dexrazoxane group. The cardiotoxicity was assessed by measuring serum cardiac troponinl (cTnI), brain natriuretic peptide (BNP), superoxide dismutase (SOD) and malondialdehyde (MDA) at the end of the 8th and 16th weeks. Results At the end of the 8th weeks the differences for cTnI, BNP, SOD, MDA, pathological performance between groups was not statistically significant (P>0.05). At the end of the 16th weeks paclitaxel increased serum cTnI and BNP (P<0.05). The dexrazoxane acceleration the increasing cTnI and BNP (P<0.05). Dexrazoxane + paclitaxel reduce SOD, increased MDA, the difference was statistically significant (P<0.05). The comparison between the different doses of dexrazoxane group was not statistically significant (P>0.05). conclusion The dexrazoxane increase paclitaxel-induced cardiotoxicity through reducing free radical scavenging enzyme activity, resulting in excessive lipid peroxidation products.

Determination of residual organic solvents in olanzapine by Gc

2013, 30(2):  21-25. 

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Objective To develop a method for the determination of five residual organic solvents in olanzapine. Methods The residual organic solvents including methanol, dichloromethane, ethanol, triethylamine and toluener were quantitatively determined by GC, and nitrogen was the carrier gas. Results Five residual organic solvents were completely separated. The linear range of methanol was 0.030 7-0.614 0 mg/mL(r=1), the linear range of ethanol was 0.051 9-1.038 0 mg/mL(r=0.999 7), the linear range of dichloromethane was 0.005 7-0.114 8 mg/mL(r=0.999 9), the linear range of triethylamine was 0.051 36-1.027 2 mg/mL(r=0.999 9), the linear range of toluener was 0.009 5-0.190 0 mg/mL(r=0.999 9). The theoretical plates of five organic solvents were much more than 5 000, the separation of the organic solvents was more than 2.0, the separation of the measured solvent and solvent blank was more than 2.0, system suitability and system precision are required. The RSDs of precision of six residual organic solvents were less than 5%, the average recovery rates of the preparation were in the range of 90%-100%. The RSDs of recovery were less than 2.0%. conclusion The method is simple, sensitive, accurate and can be used for the quality control of olanzapine.

clinical Study of Dongyuan Shengyangyiwei method in the treatment of rheumatoid arthritis

2013, 30(2):  26-29. 

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Objective To observe the process of treatment and the role of attenuated effects in the rheumatoid arthritis (RA) treatment with Shengyangyiwei method. Methods 150 patients with RA were randomly divided into two groups. 75 patients in the control group while 75 patients in the treatment group. Both groups were treated with Methotrexate Nimesulide and methylprsdnisone, while the former was added with pantoprazole sodium capsules, and the later was added with Shengyangyiwei Tang treatment. The gastric mucosal injury and gastrointestinal symptoms were observed respectively before treatment and after treatment for 30 d and 90 d. ALT、ESR、CRP of the patients were observed after treating for 30 d and 90 d. Results After 90days’ treatment, the gastric mucosal injury and gastrointestinal symptoms in the patients of the experimental group were significantly lower than that of the control group.Therefore, the differences of the total efficiency in both groups were statistically significant. (With P<0.05). As for ALT, ESR and CRP comparison, the results of the treatment group was significantly better than that of the control group, the differences were significant (P<0.05). conclusion The Shengyangyiwei Tang can effectively prevent and control the digestive side effects in RA therapy and with significant treatment effects, at the same time it has good curative effects to improve symptoms, control the disease progress etc.

clinical observation on mic-operation in treating pneumothorax

2013, 30(2):  30-33. 

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Objective To examine clinical value and complication of treating pneumothorax by using central venous catheter. Methods Ninety cases of spontaneous pneumothorax were divided into 3 equal groups randomly: Research group, treated with pleural drainage by using central venous catheter. Control group A, treated with closed thoracic drainage. Control group B, drainage with thoracentesis once a day. Results The curative effect of research group was similar with that of the control group A, better than group B evidently. The complications of surgery and the average time of duration hospitalization in research group were less than that of the control group A. conclusion The treatment of spontaneous pneumothorax is a satisfactory remedy with easy operation less side effect fewer complication and duration chest pain compared with that of the traditional methods.

Efficacy of H-FABP and IMA in the early diagnosis of acute myocardial infarction

2013, 30(2):  34-36. 

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Objectiv To evaluate the sensitivity of heart-type fatty acid-binding protein (H-FABP) and ischaemia modified albumin (IMA) in acute myocardial infarction (AMI) and compare theirs diagnostic efficacy in early stage AMI. Methods The creteria pulished by Chinese society of cardiology at December, 2001 was taken as the golden standard. H-FABP and IMA were measured in AMI patients at 2 h, 3 h, 6 h, 9 h, 24 h after the onset of chest pain, and the efficacy of these index were evaluated. Results At 2 h after chest pain, the sensitivity rate of H-FABP was 62.7%, the sensitivity of IMA was 76.5%. At 3 h after chest pain, the sensitivity rate of H-FABP was 82.4%, the sensitivity of IMA was 86.3%. At 6 h after chest pain, the sensitivity rate of H-FABP was 84.3%, the sensitivity of IMA was 80.4%. At 9 h after chest pain, the sensitivity rate of H-FABP was 64.7%, the sensitivity of IMA was 54.9%. At 24 h after chest pain, the sensitivity rate of H-FABP was 37.3%, the sensitivity of IMA was 23.5%. conclusion The sensitivity of H-FABP and IMA is high.

complicated urinary tract stones treated with holmium laster by establishing standard percutaneous nephrolithotomy channel with balloon dilation

2013, 30(2):  37-39. 

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Objective To explore the safety and clinical efficacy of the balloon dilatation establishing standard percutaneous nephrolithotomy(PCNL) channel under holmium laser treatment for complex upper urinary tract stones. Methods Selected the clinical data of 38 patients in the Affiliated Hospital of Hebei University(20 females and 18 males, the average age is 38.3 years) with complex upper urinary tract calculi who were treated by the holmium laser under the balloon dilation establishing standard PCNL channel, including 15 cases of upper calyx diverticular calculi, 15 cases of light diverticulum kidney stones and 8 cases of renal and upper ureteral stones. The stones diameter was 2.0-4.2 cm, average 2.8 cm. All patients were treated with the holmium laser, punctured by ultrasound-guided. Results One case was difficult to establish the channel due to light obvious hydrocephalus and was re-established the channel. The renal access was successfully established in 37 patients and the stones were cleared out in all cases in the first stage of treatment, the calculus clearance rate was 100%. Postoperative examination of 38 patients had no residual stones. The operation duration was 30-98 minutes, averaged 45 minutes. The blood loss was 10-65 mL, averaged 25 mL. There were no serious complications and no cases converting to open surgery cases. The length of postoperative hospital stay was 7-14 days. conclusion The balloon dilatation establishing standard PCNL channel, and holmium laser lithotripsy has the advantages of fewer trauma, less bleeding, high stone clearance rate, shorter operative time and provides a better treatment for patients with upper urinary tract stones.

Clinical Analysis of Tubeless Percutaneous Nephrolithotomy (48 cases)

2013, 30(2):  40-43. 

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Objectives To assess our initial experience in extending the implementation of tubeless PCNL without preoperative patient selection and evaluate the safety and feasibility of tubeless percutaneous nephrolithotomy. Methods All consecutive PCNL performed during 2009-2012 were evaluated. Tubeless PCNL was performed when residual stones, bleeding and extravasation were excluded intraoperatively. Staghorn stones, stone burden, supracostal and multiple accesses, anatomic anomalies, solitary kidneys and operative time were not considered contraindications. We analyzed the clinical data and the choice of tubeless. PCNL over time. Results Of 600 PCNL performed during the study period 48 (71%) were tubeless. Including 5 cases of the procedure was totally tubeless percutaneous nephrolithotomy. The postoperative recovery time and relatively cost was low, 48 patients were discharged in the short term. 1 case of bilateral and tubeless percutaneous nephrolithotomy appears postoperative high fever. The temperature returned to normal after replace cephalosporins antibiotics of three generations. One patient with totally tubeless percutaneous nephrolithotomy had severe postoperative pain and discharge after give received alimta. conclusion Tubeless PCNL can be safely and effectively performed based on intraoperative decisions, without preoperative contraindications. They are easily accommodated by experienced endourologists and provide real advantages.

Retrospective analysis on the treatment of risk factors determining arrhythmias following cardiac valve replacement

2013, 30(2):  44-48. 

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Objective To analyze the risk factors of arrhythmias and its treatment following cardiac valve replacement undergoing Cardiopulmonary bypass. Methods The clinic date of 52 patients undergoing cardiac valve replacement which were studied retrospectively. The risk factors of arrhythmias were identified by using univariate andmultivariate logistic regression analysis. Results There were 30 patients who had arrhythmia, occurrence rate 57.7%, no death case. The high risk factors of arrhythmias were preoperative arrhythmias, electrolyte disturbance, NYHA function Class Ⅲ-Ⅳ, aortic-cross clamping time≥80 min after operation respectively. conclusion Active measures to avoid occurrence of these predictors or correct them should be taken so as to decrease postoperative occurrence rate and improve prognosis.

Clinical observation of Jixue-dianduan acupuncture in the treatment of dysphagia after stroke

2013, 30(2):  49-52. 

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Objective To observe the effects of Jixue-dianduan acupuncture in treating dysphagia after stroke. Methods Randomly separated 60 patients into the observation group and the control group. Based on the neurological traditional treatment for stroke and fundamental swallowing train for each of the two groups, the control group had acupuncture on ordinary acupoints while the observation group had Jixue-dianduan acupuncture treatment. The two groups were both evaluated by the WaTian’s drinking water test after two courses of treatment. Results There were significant differences in efficacy between the two groups (P<0.05). conclusion The Jixue-dianduan acupuncture treatment is worthwhile for expanding in clinic for its striking curative effects.

Low-magnetic-field MRI diagnosis in acute cerebral hemorrhage

2013, 30(2):  53-56. 

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Objective To explore the MRI diagnosing values by analysis the low-magnetic-field MRI representaions of acute cerebral hemorrhage in 58 cases. Methods The characteristic MRI appearances of 58 patients of acute cerebral hemorrhage were retrospectively analyzed. Results The signal of acute cerebral hemorrhage was an equality T1WI , and equality or high T2WI. conclusion The signal representations of acute cerebral hemorrhage are characteristics on low-magnetic-field. MRI is an effective examining method of acute cerebral hemorrhage.

Investigation on maternal health care status and affecting factors among migrant pregnant women in Urumqi

2013, 30(2):  57-61. 

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Objective To investigate the current status of maternal health care utilization for migrant pregnant women in Urumqi. Methods Many outpatient clinics for planned immunization were selected, migrant women with under 3 year children were selected as study objects, a self-designed questionnaire was used to survey their health status during pregnancy. Results 200 migrant pregnant women were selected, the rate of pregnancy registration was 75.0%, the rate of prenatal examination was 86.0%, the rate of adequate prenatal examination was 14.0%. The rate of postpartum visit was 72.0%, the rate of adequate postpartum visit was 39.5%. The education level of migrant pregnant women and their husband, the income of their families were the main influencing factors. conclusion The maternal health care utilization for migrant pregnant women is very low, especially in the low income family and low degree culture of target population. It is necessary to increase the knowledge propaganda dynamics prenatal care.

Survey on cervical vertebra health and the related knowledge, attitudes and behaviors of college students

2013, 30(2):  62-66. 

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Objective To understand the current situation about cervical vertebra health and the related knowledge, attitudes and behaviors of college students, and provide evidence for the health education programs. Methods Using cluster sampling, selected 354 on-campus college students in Baoding and they were investigated with questionnaires. 4 groups of focus group discussion was conducted by the convenience sampling. Results 78.5% students were in the cervical fatigue, spending much time at desk and lacking of exercise, the awareness on the cervical vertebra health was low among them. 73.2% students hoped the colleges and society to conduct more related health education. conclusion Cervical vertebra health problems were widespread among college students, it is suggested to strengthen the cervical vertebra health education and behavior intervention for them.

Effects of nursing intervention on prognosis of patients with hypertensive intracerebral hemorrhage

2013, 30(2):  67-70. 

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Objective To observe the effects of nursing intervention on prognosis of patients with hypertensive intracerebral hemorrhage. Methods 298 cases with hypertensive intracerebral hemorrhage diagnosed and treated in the People’s Hospital of Rongcheng County from January in 2009 to March in 2012 were randomly divided into two groups, the observation group(n=149) and the control group(n=149). Patients in the control group received regular nursing, while patients in the observation group received nursing intervention and regular nursing. We used Barthel and FIM to evaluate the patients’ life quality and self-care ability. Results The patients’ life quality and self-care ability were approved significantly in the observation group, and there were significant difference between the 2 groups. conclusion Nursing intervention can improve life quality and self-care ability of patients with hypertensive intracerebral hemorrhage, enhance their social sense of belonging, and reduce the financial and spiritual burden on family and society.

continual nursing service for prostate cutting on the quality of life of patients with postoperative research progress

2013, 30(2):  71-75. 

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Transurethral resection of prostate (TURP) is the gold standard for treatment of benign prostatic hyperplasia (BPH). But in the treatment of patients, alleviate disease pain at the same time, it is hard to avoid the occurrence of a series of complications, many factors affect the TURP postoperative patients quality of life. Continual nursing service is the extension and expansion of hospital nursing service, its for many diseases patients life quality and recovery have certain effects. In this paper, we elaborate the role of continual nursing service for TURP postoperative patients quality of life.

Advances on the treatment of constipation with traditional chinese medicine acupoint application

2013, 30(2):  76-81. 

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This review will focus on the recent clinical research progress on the treatment of constipation with traditional Chinese medicine acupoint application,discuss the development prospects,and provide reference for the clinical research and application on the treatment of constipation with traditional Chinese medicine.

Developments on diagnosis and treatment of obstructive sleep apnea hypopnea syndrome

2013, 30(2):  82-84. 

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Obstructive sleep apnea hypopnea syndrom (OSAHS) is a chronic respiratory sleep disorders, the harm is serious, many diseases are independent risk factors, but easy to misdiagnosis and missed diagnosis. Current diagnosis methods mainly depend on many guide sleep monitoring (PSG) to diagnose, there are several trenting ways, and a variety of noninvasive ventilator is reliable medical treatment method, which can alleviate symptoms and a variety of complications.

The expression and research progress of Survivin,COX-2 in salivary gland tumors

2013, 30(2):  85-89. 

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Survivin, possessing high expression in a wide variety of tumor tissues, is the new family member of inhibitor of appoptosis proteins. As an inducible Cyclooxygenase, COX-2 has become a new method of preventing and curing cancer for its biological properties in recent years. This research on the relationship between survivin, COX-2 and salivary gland tumors has significance in theory and clinical practice.

Research progress on the influencing factor of college students’ coping style and the relationship between mental health and college students’ coping style

2013, 30(2):  90-93. 

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Through the summarization of massive internal study about the influencing factor of college students’ coping style and the relationship between mental health and college students’ coping style, the relationship between college students’ coping style and the influencing factor as sexual distinction, age, subject, hometown, parental care style, personality, as well as the effects of coping styles on mental health of college students were analyzed.

curriculum system reform in the undergraduate nursing program directed by social needs

2013, 30(2):  94-96. 

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Drawing upon the experience of the reforms at home and abroad, orienting social needs, this paper presents a program reforming four-year undergraduate nursing curriculum system. By means of optimizing the training target, the curriculum structure, the curriculum content and the practical teaching, this reform aims at designing a curriculum system orienting social needs and laying a foundation for cultivating qualified nurses meeting social needs.

Effect evaluation about PBL in experimental teaching of epidemiology for the students in clinical medicine

2013, 30(2):  97-100. 

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Objective To study the application of PBL in experimental teaching of epidemiology in the student of clinical medicine. Methods 152 students were selected. They were divided into the PBL group and traditional method group at random. The teaching effects of two groups were compared. Results The excellent rates of PBL group was higher than that of the traditional method group. conclusion PBL can effectively increase the teaching quality of epidemiology.

Emphasis on application-oriented teaching reform of medical statistics- application of statistical tables as an example

2013, 30(2):  101-103. 

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Medical Statistics is a required course for today's medical professional graduate, and statistical tables is the most common part for expressing results in the paper. Although most of the textbooks have clear requirements on the principle of statistical tables, graduates often have many problems such as not having ability to draw right tables in the practical application. During teaching statistical tables we took practice-oriented practical application, realized tables with Microsoft Word, and received good results.

Experience of teaching calculus for international students in medical university

2013, 30(2):  104-106. 

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The higher requirements are put forward with the increase of number of international students in medical university of China. As a special group in university, they have high learning enthusiasm but poor foundation of mathematics. In order to reinforce their mathematic basis and better learn other course. Some experience and expectation of teaching calculus in total English were described from several different aspects including teaching content, preparation before class, teaching mode and system of grade evaluation. This may provide reference for those who are engaging in reform of of education oriented to international students.