Research progress of WBC count and the prognosis of acute myocardial infarction

Abstract

Abstract: The rise of blood leukocyte count can reflect the prognosis of patients with acute myocardial infarction (AMI). This paper summarized from the following aspects: the mechanism of elevated white blood cell count in patients with AMI, white blood cell count and AMI reperfusion therapy, white blood cell count and AMI infarction area, the relationship between neutrophil counts and the prognosis of AMI, the relationship between neutrophil/lymphocyte ratio and the prognosis of AMI, lymphocyte count and the prognosis of AMI, monocytes and the prognosis of AMI. Research shows that in AMI early detection of peripheral blood leukocyte count and classification, reducing the white cell number and function timely have a certain clinical significance to prevent the infarction area expansion and reduce the occurrence of complications and reduce the mortality.

Key words: WBC count, acute myocardial infarction, prognosis

CLC Number:

XIAO Nuan, TANG Luning, TAN Lili, CHEN Yaqing, ZHAO Hongmei. Research progress of WBC count and the prognosis of acute myocardial infarction[J]. Medical Reserch and Education, 2014, 31(6): 89-94.

References

[1] KHAN H A, ALHOMIDA A S, SOBKI S H, et al. Blood cell counts and their correlation with creatinekinase and C-reactive protein in patients with acute myocardial infarction[J]. Int J Clin Exp Med, 2012, 5(1): 50-55.
[2] YIP H K, SUN C K, CHANG L T, et al. Strong correlation between serum levels of inflammatory mediators and their distribution in infarct-related coronary artery[J]. Circ J, 2006, 70(7): 838-845.
[3] PALMERINI T, MEHRAN R, DANGAS G, et al. Impact of leukocyte count on mortality and bleeding in patients with myocardial infarction undergoing primary percutaneous coronary interventions analysis from the harmonizing outcome with revascularization and stent in acute myocardial infarction trial[J]. Circ J, 2011, 123(24): 2829-2837.
[4] ISHIHARA M, KOJIMA S, SAKAMOTO T, et al. Usefulness of combined white blood cell count and plasma glucose for predicting in-hospital outcomes after acute myocardial infarction[J]. Am J Cardiol, 2006, 97(11): 1558-1563.
[5] SJAUW K D, VAN DER HORST I C, NIJSTEN M W , et al. Value of routine admission laboratory tests to predict thirty-day mortality in patients with acute myocardial infarction[ J]. Am J Cardiol, 2006, 97( 10): 1435-1440.
[6] NUNEZ J, FACILA L, LIACER A, et al. Prognostic value of white blood cell count in acute myocardial infarction : long-term mortality [J]. Rev Esp Cardiol, 2005, 58(6) : 631-639.
[7] SMIT J J J, OTRERVANGER J P, SLINGERLAND R J, et al. Successful reperfusion for acute ST elevation myocardial infarction is associated with a decrease in WBC count[J]. J Lab Clin Med, 2006, 147(6): 321-326.
[8] ALBERTAL M, CURA F, ESCUDERO A G, et al. Relationship between collateral circulation and successful myocardial reperfusion in acute myocardial infarction: a subanalysis of the PREMIAR trial[J]. Angiology, 2008, 59(5): 587-592.
[9] MADEN O, KACMAZ F, SELCUK H, et al. Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions[J]. Can J Cardiol, 2009, 25(6): E164-E168.
[10] PATEL M R, MAHAFFEY K W, ARMSTRONG P W, et al. Prognostic usefulness of white blood cell count and temperature in acute myocardial infarction[J]. Am J Cardiol, 2005, 95(5): 614-618.
[11] 王永祥, 于晶峰, 阿荣. 白细胞增多与急性心肌梗死面积及冠状动脉病变程度的关系[J]. 内蒙古医学院学报, 2010, 32(4): 383-386.
[12] YIP H K, YOUSSEF A A, CHANG L T, et al. Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention [J]. Circ J, 2007, 71(7): 1086-1091.
[13] REZKALLA S H, KLONER R A. Coronary no-reflow phenomenon: from the experimental laboratory to the cardiac catheterization laboratory [J]. Catheter Cardiovasc Interv, 2008, 72(7): 950-957.
[14] VRINTS C J. Pathophysiology of the no-reflow phenomenon [J]. Acute Card Care, 2009, 11(2): 69-76.
[15] NEZ J, NEZ E, BODI V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction[J]. Am J Cardiol, 2008, 101(6): 747-752.
[16] 陆奕, 付强, 刘奕, 等. 中性粒细胞/淋巴细胞比率对急性心肌梗死患者临床并发症的预测价值[J]. 江苏大学学报: 医学版, 2010, 20(2): 177-179.
[17] O’DONOGHUE M, MORROW D A, CANNON C P, et al. Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy[J]. Eur Heart J, 2008, 29(8): 984-991.
[18] BOTTO N, SBRANA S, TRIANNI G, et al. An increased platelet-leukocytes interaction at the culprit site of coronary artery occlusion in acute myocardial infarction: a pathogenic role for no-reflow phenomenon? [J]. Int J Cardiol, 2007, 117(1): 123-130.
[19] KIRTANE A J, BUI A, MURPHY S A, et al. Association of peripheral neutrophilia with adverse angiographic outcomes in ST-elevation myocardial infarction[J]. Am J Cardiol, 2004, 93(5): 532-536.
[20] NUNEZ J, NUNEZ E, BODI V, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts long-term recurrent myocardial infarction[J]. Coron Artery Dis, 2010, 21(1): 1-7.
[21] NUNEZ J, SANCHIS J, BODI V, et al. Relationship between low lymphocyte count and major cardiac events in patients with acute chest pain, a non-diagnostic electrocardiogram and normal troponin levels [J]. Atherosclerosis, 2009, 206(1): 251-257.
[22] MAEKAWA Y, ANZAI T, YOSHIKAWA T, et al. Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction: A possible role f or left ventricular remodeling [J]. J Am Coll Cardiol, 2002, 39(2): 241-246.
[23] 李春艳, 张雪娥. 急性心肌梗死患者外周血单核细胞水平对预后的影响[J]. 中西医结合心脑血管病杂志, 2009, 7(1): 23-24.
[24] 陈还珍, 刘达瑾, 郭文玲, 等. 急性心肌梗死再灌注后 CK 活性峰值出现时间与心功能关系的研究[J]. 中西医结合心脑血管病杂志, 2007, 5(10) : 942-943.