Prospect of sperm DNA damage and assisted reproductive technology research

doi:10.3969/j.issn.1674-490X.2015.01.020

Abstract

Abstract: There are multiple factors which cause sperm DNA damage,such as radiotherapy or chemotherapy, smoking, electromagnetic radiation and temperature of the testis/epididymis. Improving the methods of sperm DNA damage detection is still necessary. A number of studies have reported that sperm DNA damage is associated with reproductive outcome. For the sake of succeeding in ART and the reducing of sperm DNA damage, some treatments are taken into consideration, such as exterminating the causes, oral antioxidant drugs, traditional Chinese medicine and ICSI /IMSI with testis sperm. This review focuses on the mechanism and detection of sperm DNA damage, it’s association with reproductive outcomes, and relevant treatment strategies in assisted reproductive technology.

Key words: sperm, DNA damage, methods of sperm DNA damage detection

CLC Number:

HE Dandan, LI Shaopeng, LI Yan, ZHAO Xiaorui, WANG Zelan, PAN Xiao. Prospect of sperm DNA damage and assisted reproductive technology research[J]. Medical Reserch and Education, 2015, 32(1): 85-91.

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