Abstract: Objective To compare the effects of acetate ringers solution and lactated ringers solution on metabolic acidosis in patients with hemorrhagic shock. Methods 50 patients with hemorrhagic shock were divided equally into 2 groups randomly(n=25): the acetate ringers solution(group A) and lactated ringers group(group L). Changes of arterial blood gas and volume of NaHCO₃ before and 1, 2, 3, 4h after induction respectively were observed. Results There were no statistics difference in the ASA grade, operation time, the volume of transfusion during operation and hemorrhage volume of both groups(P>0.05). pH in group A changed at time point of T3 respectively compared to group L(P<0.05). Serum lactate level(LAC) decreased at T₂ compared to T0 time in group A(P<0.05). LAC level increased at T₂, T₃, T₄ compared to T0 time in group L(P<0.05). LAC level in group L increased at time point of T₂, T₃, T₄ compared to group A(P<0.05). Volume of NaHCO₃ in group A decreased compared to group L (P<0.05). Conclusion Acetate ringers solution changes pH, decreases serum lactate level and decreases volume of NaHCO₃ during fluid resuscitation in hemorrhagic shock.

Key words: hemorrhagic shock, acetate ringers solution, lactated ringers solution, arterial blood gas