Medical Reserch and Education ›› 2015, Vol. 32 ›› Issue (5): 26-28.DOI: 10.3969/j.issn.1674-490X.2015.05.007

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Clinical estimation of different concentration of mytomycin C in treating in patients with II-III styles chronic suppurative sinusitis

GAO Yongping, LIU Huiqing, MA Jinying, RAN Cheng, DU Jinduo   

  1. Department of ENT, Affiliated Hospital of Hebei University,Baoding 071000,China
  • Online:2015-10-25 Published:2015-10-25

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Abstract: Objective To assess the efficacy of different concentration mitomycin C (MMC) in treating patients with II-III styles chronic suppurative sinusitis to find out an effective method for using MMC. Methods 420 cases with II-III styles chronic suppurative sinusitis were randomized to group A and group B. The patients in group A were used 0.2 g/L MMC in operation, group B used 0.4 g/L MMC in operation. All patients had follow-up study with the time of 18-30 months(20.5±1.02 months) postoperatively. Results In group A,186 cases were cured,the cure rate was 88.6%, nasal cavity adhesion were 24 cases,invalid rate was 11.4%. In group B, 202 cases were cured,the cure rate was 96.2%, nasal cavity adhesion were 8 cases, invalid rate was 3.8%. Conclusion Intraoperative MMC seems to be a safe and effective procedure and can decrease nasal cavity adhesion.

Key words: mitomycin C (MMC), nasal cavity adhesion, chronic suppurative sinusitis

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