Abstract: Objective To investigate the effects of serum high-sensitivity C-reactive protein(hs-CRP)value on positive rate of prostate puncture in patients with prostate biopsy. Methods In this study, we selected 230 patients who underwent prostate biopsy in our hospital from May 2013 to May 2017 as subjects, and 150 patients with benign prostatic hyperplasia(BPH)were diagnosed as prostate cancer(PCa)in 80 cases.The effects of hs-CRP and other factors on the positive rate of prostate puncture were analyzed by multivariate logistic regression. Results(1)The hs-CRP level of PCA patients was significantly higher than that in BPH patients(P<0.05).(2)In 76 cases of hs-CRP>3 mg/L, the number of PCA was 42 cases, and the positive rate of puncture was 55.26%(42/76). In 154 cases, the number of PCA patients was 38 cases, and the positive rate of puncture was 24.68%(38/154)hs-CRP≤3 mg/L. The positive rate of prostate puncture in hs-CRP>3 mg/L was significantly higher than that of hs-CRP≤3mg/L(P<0.05).(3)By multivariate logistic regression analysis, hs-CRP is an independent risk factor affecting the positive rate of prostate puncture. Conclusion hs-CRP is an independent risk factor affecting the positive rate of prostate puncture, the positive rate of prostate puncture increases significantly when the level of serum is increased, which has significance in the clinical diagnosis of the disease.

Key words: prostate puncture positive rate, prostatic cancer, prostatic hyperplasia, high-sensitivity C-reactive protein