doi:10.3969/j.issn.1674-490X.2020.03.003

Abstract

Abstract: Objective To evaluate the prognostic and clinicopathological significance of AXL expression in breast cancer tissues by meta-analysis. Methods Such databases as CNKI, Wanfang Data, Cochrane Library, Embase, PubMed and Medline were searched for the studies on the prognostic value of AXL expression in breast cancer from inception to October 2019. Two researchers independently screened eligible literature, extracted data and evaluate the risk of bias of included studies to analyze the data. Results Seven studies involving 933 patients were included. It was shown that,the higher AXL expression group had a shorter overall survival than that of the lower AXL expression group(HR=2.36, 95%CI 1.60-3.46, P<0.000 1). However,there was no significant difference between two group in relapse free survival and disease free survival. It was shown that the expression of AXL was not associated with age, clinical stages, histologic grade, lymph node metastasis or receptor expression. Conclusion The meta-analysis suggests that AXL positive expression is associated with worse survival in patients. It will be a protential molecular marker for individualized treatment of breast cancer.

Key words: AXL, breast cancer, meta-analysis, prognosis

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References

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