Abstract: Objective To explore the changes of blood urea nitrogen(BUN)in the monitoring of stress ulcer bleeding in critically ill patients and its correlation with the amount of bleeding. Methods Retrospective collection of critically ill patients in Tangshan Hongci Hospitals complicated with stress ulcer bleeding of clinical data(30 cases)and the same number of clinical data without stress ulcer bleeding were randomly selected as the experimental group and the control group, the clinical information of the monitoring of two groups of patients with BUN and creatinine(Cr), BUN/Cr ratio, white blood cell(WBC)count, hemoglobin(Hb), and the variable difference analysis were examined.Results In the bleeding group, BUN, BUN/Cr and WBC at 1 week and 2 weeks after admission were higher than those in the control group and this group at 24 hours after admission(P<0.001), Hb was lower than those in the control group and this group at 24 hours after admission(P<0.001).There was no significant change in Cr between the two groups(P<0.05).Conclusion BUN, BUN/Cr and WBC can be used as simple and effective indexes for early detection of stress ulcer bleeding and prediction of bleeding degree in critical patients.

Key words: stress ulcer, bleeding, blood urea nitrogen, blood urea nitrogen/ creatinine ratio, white blood cell count, hemoglobin content