doi:10.3969/j.issn.1674-490X.2021.04.003

Abstract

Abstract: Objective To observe the relationship between the expression of miRNA-425-5P and clinicopathological features of gastric cancer(GC)patients. Methods The expression of miRNA-425-5P in 90 cases of GC tissues and cells(MGC-803, SGC-7901)were detected with qRT-PCR assay. The relationship between miRNA-425-5P expression and clinicopathological features of gastric cancer were analyzed. Results The expression of miRNA-425-5P in GC tissues and cells were significantly increased(P<0.05), and it correlated with depth of invasion(χ²=6.106, P=0.014)and TNM stages(χ²=4.472, P=0.035), rather than the age(χ²=0.266, P=0.606), sex(χ²=1.593, P=0.207), lymphatic metastasis(χ²=1.829, P=0.176)and nerve/vessel invaded(χ²=1.029, P=0.310)of GC patients. Conclusion The expression of miRNA-425-5P is an independent prognostic risk factors of gastric cancer, which can be expected to serve as a marker for the diagnosis, treatment, and evaluation of the prognosis of gastric cancer in clinical practice.

Key words: miRNA-425-5P, gastric cancer, expression, prognosis

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References

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