doi:10.3969/j.issn.1674-490X.2023.02.005

Abstract

Abstract: Sepsis is a life-threatening critical illness caused by infection. Serum phosphorus plays an important role in the process of sepsis. Phosphorus is an element component of the body with many biological activities. It participates in the composition of the cell membrane phospholipid bilayer and maintains the normal structure and function of cell membrane. In addition, phosphorus as a component of ATP enzyme is involved in energy storage and transport. It also plays an important role in oxygen delivery, regulation of enzyme activity, and maintenance of acid-base balance in the body. Patients with sepsis often have hypophosphatemia, which is related to multiple organ dysfunction. This paper summarizes the changes of serum phosphorus in sepsis, and provides a new idea for further research and treatment of sepsis.

Key words: sepsis, serum phosphorus, multiple organ dysfunction, critical illness, prognosis

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References

[1] NAPOLITANO L M. Sepsis 2018: definitions and guideline changes[J]. Surg Infect(Larchmt), 2018, 19(2): 117-125. DOI: 10.1089/sur.2017.278.
[2] ARINA P, SINGER M. Pathophysiology of sepsis[J]. Curr Opin Anaesthesiol, 2021, 34(2): 77-84. DOI: 10.1097/aco.0000000000000963.
[3] 张笑婷,纪文焘,薄禄龙,等.脓毒症基础研究的进展及未来方向[J].中华危重病急救医学, 2021, 33(8): 919-921. DOI: 10.3760/cma.j.cn121430-20210126-00132.
[4] 何雪梅,薄禄龙,姜春玲.脓毒症免疫抑制与免疫刺激治疗的研究进展[J].中华危重病急救医学, 2018, 30(12): 1202-1205. DOI: 10.3760/cma.j.issn.2095-4352.2018.12.020.
[5] 梁娜,祝益民.脓毒症高代谢的研究进展[J].中国小儿急救医学, 2014, 21(12): 807-809. DOI: 10.3760/cma.j.issn.1673-4912.2014.12.018.
[6] 付阳,陈捷,蔡蓓,等.血清降钙素原和免疫炎性因子C反应蛋白、白介素-6、血清淀粉样蛋白A在脓毒血症中的诊断价值[J].四川大学学报(医学版), 2012, 43(5): 702-705. DOI: 10.13464/j.scuxbyxb.2012.05.036.
[7] FAIX J D. Biomarkers of sepsis[J]. Crit Rev Clin Lab Sci, 2013, 50(1): 23-36. DOI: 10.3109/10408363.2013.764490.
[8] 张建群.低磷血症在危重症患者中的临床意义及研究进展[J].中国现代药物应用, 2014, 8(12): 240-242. DOI: 10.14164/j.cnki.cn11-5581/r.2014.12.108.
[9] ZAVATTA G, ALTIERI P, VANDI G, et al. Phosphate metabolism and pathophysiology in parathyroid disorders and endocrine tumors[J]. Int J Mol Sci, 2021, 22(23): 12975. DOI: 10.3390/ijms222312975.
[10] MANGHAT P, SODI R, SWAMINATHAN R. Phosphate homeostasis and disorders[J]. Ann Clin Biochem, 2014, 51(pt 6): 631-656. DOI: 10.1177/0004563214521399.
[11] LEUNG J, CROOK M. Disorders of phosphate metabolism[J]. J Clin Pathol, 2019, 72(11): 741-747. DOI: 10.1136/jclinpath-2018-205130.
[12] PENIDO M G M G, ALON U S. Phosphate homeostasis and its role in bone health[J]. Pediatr Nephrol, 2012, 27(11): 2039-2048. DOI: 10.1007/s00467-012-2175-z.
[13] BHADADA S K, RAO S D. Role of phosphate in biomineralization[J]. Calcif Tissue Int, 2021, 108(1): 32-40. DOI: 10.1007/s00223-020-00729-9.
[14] BLAINE J, CHONCHOL M, LEVI M. Renal control of calcium, phosphate, and magnesium homeostasis[J]. Clin J Am Soc Nephrol, 2015, 10(7): 1257-1272. DOI: 10.2215/cjn.09750913.
[15] URSEM S R, VERVLOET M G, DE JONGH R T, et al. Oxidation of parathyroid hormone[J]. Clin Chim Acta, 2020, 506: 84-91. DOI: 10.1016/j.cca.2020.03.020.
[16] LOMBARDI G, ZIEMANN E, BANFI G, et al. Physical activity-dependent regulation of parathyroid hormone and calcium-phosphorous metabolism[J]. Int J Mol Sci, 2020, 21(15): 5388. DOI: 10.3390/ijms21155388.
[17] TINAWI M. Disorders of calcium metabolism: hypocalcemia and hypercalcemia[J]. Cureus, 2021, 13(1): e12420. DOI: 10.7759/cureus.12420.
[18] DEBOWSKA M, DAI L, WOJCIK-ZALUSKA A, et al. Association between biomarkers of mineral and bone metabolism and removal of calcium and phosphate in hemodialysis[J]. Blood Purif, 2020, 49(1/2): 71-78. DOI: 10.1159/000503623.
[19] MANTOVANI G, ELLI F M. PTH resistance[J]. Mol Cell Endocrinol, 2021, 531: 111311. DOI: 10.1016/j.mce.2021.111311.
[20] KHUNDMIRI S J, MURRAY R D, LEDERER E. PTH and vitamin D[J]. Compr Physiol, 2016, 6(2): 561-601. DOI: 10.1002/cphy.c140071.
[21] SONG L. Calcium and bone metabolism indices[J]. Adv Clin Chem, 2017, 82: 1-46. DOI: 10.1016/bs.acc.2017.06.005.
[22] BIENAIMÉ F, PRIÉ D, FRIEDLANDER G, et al. Vitamin D metabolism and activity in the parathyroid gland[J]. Mol Cell Endocrinol, 2011, 347(1/2): 30-41. DOI: 10.1016/j.mce.2011.05.031.
[23] NIEDZIELA N, PIERZCHAŁA K, ZALEJSKA-FIOLKA J, et al. Assessment of biochemical and densitometric markers of calcium-phosphate metabolism in the groups of patients with multiple sclerosis selected due to the serum level of vitamin D3[J]. Biomed Res Int, 2018, 2018: 9329123. DOI: 10.1155/2018/9329123.
[24] 杨凡.维生素D: 综述和指南解读[J].中华妇幼临床医学杂志(电子版), 2010, 6(4): 229-230. DOI: 10.3969/cma.j.issn.1673-5250.2010.04.001.
[25] MATTHIAS J, CUI Q X, SHUMATE L T, et al. Extra-large Gα protein(XLαs)deficiency causes severe adenine-induced renal injury with massive FGF23 elevation[J]. Endocrinology, 2020, 161(1): bqz025. DOI: 10.1210/endocr/bqz025.
[26] RODRÍGUEZ M. FGF23: is it another biomarker for phosphate-calcium metabolism?[J]. Adv Ther, 2020, 37(2): 73-79. DOI: 10.1007/s12325-019-01181-4.
[27] IMEL E A, BIGGIN A, SCHINDELER A, et al. FGF23, hypophosphatemia, and emerging treatments[J]. JBMR Plus, 2019, 3(8): e10190. DOI: 10.1002/jbm4.10190.
[28] AL HARBI S A, AL-DORZI H M, AL MESHARI A M, et al. Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock[J]. BMC Pharmacol Toxicol, 2021, 22(1): 30. DOI: 10.1186/s40360-021-00487-w.
[29] ARIYOSHI N, NOGI M, ANDO A, et al. Hypophosphatemia-induced cardiomyopathy[J]. Am J Med Sci, 2016, 352(3): 317-323. DOI: 10.1016/j.amjms.2016.04.013.
[30] GEERSE D A, BINDELS A J, KUIPER M A, et al. Treatment of hypophosphatemia in the intensive care unit: a review[J]. Crit Care, 2010, 14(4): R147. DOI: 10.1186/cc9215.
[31] BARAK V, SCHWARTZ A, KALICKMAN I, et al. Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines[J]. Am J Med, 1998, 104(1): 40-47. DOI: 10.1016/s0002-9343(97)00275-1.
[32] ZHAO J N, TAN Y, WANG L, et al. Serum sphingosine-1-phosphate levels and Sphingosine-1-Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study[J]. J Transl Med, 2020, 18(1): 156. DOI: 10.1186/s12967-020-02322-y.
[33] 王颖勤,钟鸣,诸杜明.鞘氨醇-1-磷酸在脓毒症中调节作用的研究进展[J].中国临床医学, 2018, 25(6): 977-982. DOI: 10.12025/j.issn.1008-6358.2018.20180150.
[34] SHEU C C, GONG M N, ZHAI R, et al. Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS[J]. Chest, 2010, 138(3): 559-67. DOI: 10.1378/chest.09-2933.
[35] LIU Y C, YU M M, SHOU S T, et al. Sepsis-induced cardiomyopathy: mechanisms and treatments[J]. Front Immunol, 2017, 8: 1021. DOI: 10.3389/fimmu.2017.01021.
[36] O'CONNOR L R, WHEELER W S, BETHUNE J E. Effect of hypophosphatemia on myocardial performance in man[J]. N Engl J Med, 1977, 297(17): 901-903. DOI: 10.1056/NEJM197710272971702.
[37] CLAUDIUS I, SACHS C, SHAMJI T. Hypophosphatemia-induced heart failure[J]. Am J Emerg Med, 2002, 20(4): 369-370. DOI: 10.1053/ajem.2002.33950.
[38] 肖瑶.低磷血症的发生及其对机体的影响[J].临床和实验医学杂志, 2007, 6(4): 161-163. DOI: 10.3969/j.issn.1671-4695.2007.04.119.
[39] 李婉丽,李建国.脓毒症相关性血小板减少症的研究及治疗进展[J].大连医科大学学报, 2018, 40(6): 549-552. DOI: 10.11724/jdmu.2018.06.16.

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