Abstract: Objective To investigate and compare the changes of hemodynamic and the occurrence of adverse reaction of etomidate and propofol used in short time neurosurgery.Methods 50 patients undergone elective neurosurgery, whose operation time was limited to 2-3 hours, were randomly divided into etomidate group (group E, n=25) and propofol group (group P, n=25). Induction with sufentanil 0.3 μg/kg, rocuronium 0.6 mg/kg, group P with propofol 2.0 mg/kg, group E with etomidate 0.3 mg/kg. Recording the basal state (T0), beforeintubation moment (T1), after intubation (T2) and 1 min after intubation (T3), 3 min (T4), 5 min (T5), 10 min (T6), systolic blood pressure(SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), oxygen saturation (SpO2) and heart rate (HR), recording the application of vasoactive drugs, intake and output, the recovery time and extubation time and the incidence of adverse reactions were recorded. Results (1) The fluid volume, operation time, anesthesia time, postoperative recovery time after extubation were not difference in patients in the two groups. (2) In group P, in T4, T5, T6, SBP, DBP decreased significantly (P<0.05 or P<0.01). In T3 HR increased obviously (P<0.05), in T4, T5, T6, decreased (P<0.05). In group E T3, T4, HR increased significantly (P<0.05 or P<0.01). (3) The highest HR, the highest SBP and the lowest SBP, were of no statistical significance, application of vasoactive drugs in patients in the two group were 4% in group E, and 16% in group P, the difference was statistically significant (P<0.01). (4) Injection pain was significantly lower in the group E than that in group P(P<0.01). Conclusion Etomidate can be safely applied in short-time neurosurgery operation. Compared with propofol, etomidate has less influence on hemodynamic in induction and maintenance, but the postoperative restlessness, nausea, vomiting were higher.

Key words: general anesthesia, Etomidate, Propofol, neurosurgery