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Table of Content

    25 June 2015, Volume 32 Issue 3
    Effects of different solvents on the polypeptide antigen’s emulsification
    LOU Yongfu, ZHANG Xuejiao, LIU Jialin, WANG Rongai, LIU Shaochuan, MENG Ming
    2015, 32(3):  1-5.  DOI: 10.3969/j.issn.1674-490X.2015.03.001
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    Objective To study the effects of different solvents (sterile water and PBS buffer) on the polypeptide antigen’s emulsification. Methods Dissolved polypeptide antigen was completely emulsified with complete Freund’s adjuvant by the way of pull-and-push with an artificial blender connecting three-way pipe and two yringes. The effects of emulsified mixture were evaluated by water drip test. Results The emulsification time was longer and the procedure was easy to control by taking the sterile water as solvent. The stable water in oil emulsifier was formed in a short time by taking the PBS buffer as solvent, whereas it was easy to get over emulsified. Conclusion The effects of different solvents on the polypeptide antigen’s emulsification were different significantly.
    Candesartan on morphological change of artery in atherosclerosis rats
    ZHOU Yujuan, LIU Li, LIU Chunying, CAO Xiaohua, CHEN Taoping
    2015, 32(3):  6-10.  DOI: 10.3969/j.issn.1674-490X.2015.03.002
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    Objective To investigate the effects of Candesartan on morphological change of the artery in atherosclerosis model rats. Methods Normal rats were fed with high lipid feedstuff to set up atherosclerosis rat model. Fifty rats were randomly divided into normal group, atherosclerosis model group, groups of low, medium and high dose of Candesartan. After 12 weeks, the arteries of the same place in rats of each group were determined and observed under light microscope and electron microscope. At the same time, we measured the intimal and medial thickness of vascular walls. Results Compared with normal group, morphological change of atherosclerosis in the arteries of model group had been observed. Compared with model group, morphological change of atherosclerosis which could be observed under microscope of the Candesartan group had decreased. In model group, compared with normal group, the intimal and medial thickness of vascular walls were significantly increased(P<0.01). Compared with model group, the intimal and medial thickness were significantly reduced(P<0.01). Conclusion Candesartan can influence the morphology of artery in atherosclerosis rats and reduce the hyperplasia in the intima and media of vascular walls.
    Expression of C-erbB-2, Bmi-1 and PTEN gene in colorectal carcinoma and its clinical significance
    ZHENG Zhaozhao1, ZHAO Chunqing2
    2015, 32(3):  11-15.  DOI: 10.3969/j.issn.1674-490X.2015.03.003
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    Objective To study expression of C-erbB-2, Bmi-1 and PTEN gene in colorectal carcinoma and its clinical significance. Methods 50 cases of colorectal carcinoma tissues and 50 cases of adjacent normalcolorectal mucosa were detected by immunohistochemical method, and the expression of C-erbB-2, Bmi-1 and PTEN gene in the study of the correlations and three genes were examined. Results (1) The expression of C-erbB-2, Bmi-1 gene in colorectal cancer tissues were significantly higher than the expression in normal colorectal tissues the expression of PTEN gene in colorectal carcinoma was significantly lower than the expression in normal colorectal tissues, the difference was statistically significant. (2) C-erbB-2, Bmi-1 gene in colorectal cancer and lymph node metastasis, degree of differentiation, depth of invasion, Ducks stage were positively correlated, and the incidence of colorectal cancer, the development and biological behavior had a role. While PTEN gene in colorectal cancer and lymph node metastasis, degree of differentiation, depth of invasion, Ducks staging were negatively related with colorectal cancer, the occurrence, development and biological behavior of inhibitory effect. (3) There was a correlation between C-erbB-2, Bmi-1 and PTEN genes in 3 colorectal cancer tissues, where C-erbB-2 and Bmi-1 genes in the development of colorectal cancer was related to the occurrence and development process. C-erbB-2 and PTEN genes of colorectal carcinoma was negatively correlated. Bmi-1 and PTEN gene in colorectal cancer development was negatively correlated. Conclusion C-erbB-2, Bmi-1 and PTEN gene in the occurrence play a role in the development of colorectal cancer, combined detection may be a prognostic marker and targeted therapy.
    Application with adaptive statistical iterative reconstruction and low radiation in the pulmonary angiography
    ZHAO Yongxia, CHANG Jin, ZUO Ziwei, ZHANG Changda, ZHANG Tianle, MENG Bo, LI Dan,ZHANG Linlin, ZHU Changyue, LI Shenglan
    2015, 32(3):  16-21.  DOI: 10.3969/j.issn.1674-490X.2015.03.004
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    Objective To investigate the effect of adaptive statistical iterative reconstruction and low radiation on the image quality of CT pulmonary angiography. Methods 150 patients whose body mass index was from 20 to 25 were divided into 5 groups underwent pulmonary angiography on a GE HD 750 CT scanners. The scanning range was from 260mm to 310mm, the first group of scan parameters were 120kV,400mAs, it was the acquiescent parameters of the CT scanner. Reconstruction was performed with ASIR, then the signal to noise ratio (SNR) and contrast to noise ratio(CNR) were calculated. The images of different strength of ASIR were read by 2 independent radiologists with 5-point-scale, then based 120kV, the other group patients were scaned with 350 mAs, 300 mAs, 250 mAs, 200 mAs, recorded the CTDIvol and DLP in different mAs. The effective dose (ED) was calculated based on the DLP, The SNR and CNR were calculated and the image quality were assessed by the two experienced readers. Results The images were assessed under different mAs (400 mAs, 350 mAs, 300 mAs, 250 mAs, 200 mAs) and the 120kV at the strength of 3, the values of the SNR and CNR were 22.95, 22.90, 21.82, 20.80, 20.83 and 23.61, 22.88, 22.86, 21.93, 21.97. The values of from 400 mAs to 200 mAs by two independent radiologists were 4.59±0.32, 4.48±0.30, 4.82±0.28, 4.28±0.36, 4.15±0.38. The CTDIvol and DLP of different mAs (400 mAs,350 mAs, 300 mAs, 250 mAs, 200 mAs) were 13.84 mGy, 11.18 mGy, 9.31 mGy, 8.25 mGy, 7.38 mGy and 351.21 mGy, 312.32 mGy, 286.26 mGy, 233.52 mGy, 206.08 mGy. the ED were 5.27 mSv, 4.68 mSv, 4.29 mSv,3.50 mSv, 3.09 mSv. Statistical analysis was performed using analysis of variance, and the date was not statistically significant(F=5.285, P>0.05) at the exposure factors of 200 mAs, 250 mAs, 300mAs, 350mAs than 400 mAs, but the CTDIvol and DLP of 200mAs were reduced 46.7% and 41.3%, the ED was reduced 41.3%. respectively than the 400 mAs. Conclusion The best mAs is from 200 mAs for the average person whose BMI is from 20 to 25 in CTPA. For smaller (less muscle) or emphysema and other diseases it can be choosen from 180 mAs to 200 mAs.
    Clinical study between blood glucose fluctuation and prognosis of severe cerebral hemorrhage patients
    ZHAO Huixin, DI Weiying, YUAN Bei, CUI Lei, ZHANG Xinghong, YAN Yi, SONG Yueping
    2015, 32(3):  22-25.  DOI: 10.3969/j.issn.1674-490X.2015.03.005
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    Objective To discuss the correlation between blood glucose fluctuation and prognosis of severe cerebral hemorrhage patients. Methods 58 patients with severe cerebral hemorrhage were selected as subjects. The clinical characteristics of all the patients were analyzed,such as mechanical ventilation, days of hospitalization , acute physiology and chronic health evaluation II (APACHE II) score. Those patients were divided into two groups: survival group (n=41) and death group (n=17). Initial blood glucose, blood glucose value, mean number of blood glucose, standard deviation of blood glucose and variation coefficient of blood glucose were recorded. Standard deviation and variation coefficient of blood glucose were used as glucose variability index to explore the correlation between blood glucose fluctuation and death. Results Mechanical ventilation, days of hospitalization, APACHE II score in death group were higher than the control group (P<0.05). Standard deviation and variation coefficient of blood glucose in death group were significantly higher than that of the survival group(P<0.05). Conclusion Blood glucose fluctuation and severe cerebral hemorrhage in the patients may be closely correlated with prognosis.
    Clinical study of maxillary protraction appliance combined with modified Nance arch and maxillary protraction and rapid palatal expansion in skeletal class Ⅲ malocclusion
    RAN Yidong, LIU Xuan
    2015, 32(3):  26-30.  DOI: 10.3969/j.issn.1674-490X.2015.03.006
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    Objective To compare the clinical investigation of maxillary protraction appliance combined with modified Nance arch and maxillary protraction and rapid palatal expansion andevaluate the changes of patients with skeletal class III malocclusion in skeletal ,dental, profile and before and after the treatment to evaluate the clinical efficacy. Methods 24 patients with skeletal class Ⅲ malocclusion in mixed dentition were divided into two groups who were treated with maxillaryprotraction combined with modified Nance arch and maxillary protraction and rapid palatal expansion.Cephalometric radiographs were analyzed to evaluate skeletodental and profile changes before and after treatment. Results SNA and ANB angle, NA-PA, Ptm-A, were increased and subspinales wereprotracted by 1.99 mm and 2.61 mm. All of the changes were statistically significant (P<0.05).Results Both of the maxillary protraction combined with modified Nance arch.andmaxillary protraction and rapid palatal expansion were obviously effective for skeletal class III malocclusion in mixed dentition, but maxillary protraction and rapid palatal expansion are much better in protracting subspinales.
    Clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ
    ZHANG Gang, QI Juan, LI Zhong, LIN Xiaomeng, CAI Qianqian, HAO Xin
    2015, 32(3):  31-35.  DOI: 10.3969/j.issn.1674-490X.2015.03.007
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    Objective To explore the clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ. Methods SP immunohistochemical were used to detect the expression of molecular markers(BRCA1, BRCA2, C-erbB-2, P53, Bcl-2) in 100 cases of invasive ductal breast cancer, 60 cases of ductal carcinoma in situ, and 100 cases of Hyperplastic disease. The changes reasons and correlation between molecular markers and breast cancer were analyzed. Results Contrast of ductal carcinoma in situ and Hyperplastic disease, biological molecular markers of 100 cases of invasive ductal breast cancer (BRCA1, BRCA2, C-erbB-2, P53, Bcl-2) all had some changes, and the changes of BRCA1, P53 expression were correlated with breast cancer(P<0.05). Conclusion Expression of BRCA1, P53 protein can be helpful in the prediction of the biological behavior and prognosis of invasive ductal breast cancer.
    The efficacy evaluation of interferon alpha on JAK2V617F positive polycythemia vera
    GUO Huimei, XUE Hua, WANG Jing, TIAN Mingjie, ZHAO Xuelian
    2015, 32(3):  36-39.  DOI: 10.3969/j.issn.1674-490X.2015.03.008
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    Objective To observe the clinical efficacy of interferon alpha(IFN-α) in the treatment of polycythemia vera(PV) patients with JAK2V617F mutation. Methods 21 patients of PV with JAK2V617F mutation were treated with IFN-α, and 18 patients were treated with hydroxyurea(HU) as a control. The changes of blood cell counts and spleen sizes were observed. The expression levels of JAK2V617F were detected by real-time fluorescent quantitative PCR. The hematologic remission rate and molecular remission rate were compared between two groups. Results The overall hematologic remission rate(complete and partial remission) of IFN-α group was 85.71%, which was significantly higher than that of HU group(55.56%). The overall molecular remission rate(complete and partial remission) of IFN-α group was 71.43%, and HU group was 5.56%, the difference was statistically significant. Conclusion Compared with HU, IFN-α not only can make PV patients get a higher hematologic remisson rate, but also can reduce the load of JAK2V617F to reach molecular remisson.
    Puncture in treating tuberculous serositis complications and its treatment methods
    JI Pengxian
    2015, 32(3):  40-43.  DOI: 10.3969/j.issn.1674-490X.2015.03.009
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    Objective To explore puncture in the treatment of tuberculous serositis complications and disposal methods. Methods Some causes failed with puncture, catheter occlusion, hemorrhage, bleeding at the puncture point, gas into serous cavity problem resulted from using disposable dispenser pack treating in the patients with tuberculosis serositis were analysed, and some appropriate disposal methods were explored. Results Through timely and symptomatic treatment, significant effects were achieved. Conclusion Puncture in treating tuberculous serositis has good effects, but also prone to arise some complications, thus, proper treatments should be taken to reduce its incidence.
    Comparison of the diagnosis of vaginal and abdominal B ultrasound examination in pregnancy uterine scar
    CHEN Chunyan
    2015, 32(3):  44-47.  DOI: 10.3969/j.issn.1674-490X.2015.03.010
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    Objective To investigate the comparison of vaginal and abdominal B ultrasound examination in the diagnosis of uterine scar pregnancy.Methods From July, 2012 to July, 2014 83 patients with uterine scar pregnancy were conducted with vaginal and abdominal B ultrasound examination. The misdiagnosis rate of two kinds of examination methods were compared to observe the ultrasonographic manifestations of patients with different types of uterine scar pregnancy. Results Off 77 cases diagnosed with vaginal B ultrasound, 6 cases were misdiagnosed, the diagnosis rate was 92.77%, among 66 cases diagnosed with abdominal B ultrasound, 17 cases were misdiagnosed, the diagnosis rate was 79.52. Comparied the two inspection diagnosis rate, the difference was statistically significant (P<0.05). 6 cases were misdiagnosed with vaginal B ultrasound, they were misdiagnosed as corpus luteum rupture in 4 cases and inflammatory mass hemorrhage in 2 cases. 17 cases were misdiagnosed with abdominal B ultrasound examination, of them, 9 cases were misdiagnosed as rudimentary uterine horn pregnancy, 3 cases as corpus luteum rupture hemorrhage, 5 cases as inflammatory mass. Conclusion Using transvaginal B ultrasound for uterine scar has higher rate of diagnosis with abdominal B ultrasound. Transvaginal B ultrasound combined with abdominal B ultrasound examination are performed to analyze the results of ultrasonic image, meanwhile the changes of HCG in the blood are taken into consideration to improve the diagnosis rate of uterine scar pregnancy and the detection rate.
    Study on phloroglucin combined with estradiol valerate for postmenopausal embedded IUDs removal operation
    XU Xiaoning, CUI Yakun, LU Zhiru
    2015, 32(3):  48-51.  DOI: 10.3969/j.issn.1674-490X.2015.03.011
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    Objective To investigate the curative effects of phloroglucin combined with progynova in postmenopausal women with embeded IUDs removal operation. Methods 317 postmenopausal women who experienced 1-3 times failure of IUDs removal operations were randomly divided into three groups. Patients in group A took progynova (2 mg qd) orally, and served it for 5 days before the operation, and then locally injected phloroglucin 40 mg at cervical 2 points, 10 points, 10min before the operation. Patients in group B was only treated with progynova (2 mg qd) orally, and served for 5 days before operation. In group C, we only administered phloroglucin 40 mg at cervical 2 points, 10 points, 10min before the operation. The observation index were the degree of pain and cervical softening degree during the IUD removal operation. Results The cervical softening degree in group A had statistically differences than that in group B and group C respectively (P<0.05). Among the three groups, the degree of pain in group A showed statistically differences than thatin group B and group C(P< 0.05). Conclusion The application of phloroglucin combined with progynova on postmenopausal women during embedded IUDs removal operation can not only improve the cervical softening degree, but also can relieve the pain of patients, and increase the success rate, which is worthy for clinical distribution.
    Observation on treating effects of thyroidectomy and traditional thyroidectomy with modified small incision
    HE Xun
    2015, 32(3):  52-55.  DOI: 10.3969/j.issn.1674-490X.2015.03.012
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    Objective To investigate the clinical therapeutic effects with modified small incision in treating thyroidectomy and traditional thyroidectomy. Methods From 2012 January to 2014 December 84 cases of patients with thyroid resection in our hospital were randomly divided into two groups, the observation group of 42 cases and control group 42 cases, the patients in the control group were treated with the readitional method, the observation group were treated with modified small incision thyroidectomy operation mode, the operation time, intraoperative bleeding volume, postoperative hospitalization time and the overall treatment effects of the two groups were compared according to the VAS score standard to evaluate the quality of life of patients after operation. Results The average operation time (85.37±21.35) min, average amount of bleeding during the operation of min (21.09±5.48) mL, the average postoperative hospital stay (3.29±0.84) d of the observation group was significantly better than that of the control group, and the average operation time (132.67±38.44) min, amount of bleeding during the operation of min (34.15±5.27) mL, postoperative hospital stay (6.35±1.48) d of the control group were higher than that of the observation group, the difference was statistically significant (P<0.05).The effective rate of the observation group was 97.62%, the effective rate of the control group 95.38%, the difference was not statistically significant (P>0.05). The pain score in the observation group was significantly lower than that of the control group, the quality of life of the patients in the observation group was improved after surgery, the difference was statistically significant (P<0.05). Conclusion Compared with the traditional thyroidectomy, the improved small incision thyroidectomy has shorter operation time, intraoperative bleeding volume, postoperative hospitalization time is short, quality of life is improved, the treatment effects are stable, which is an ideal way for thyroid resection mode.
    Application of etomidate anesthesia in short-time neurosurgery operation
    REN Feng, LIU Bin, LYU Lin, LU Xinlai
    2015, 32(3):  56-60.  DOI: 10.3969/j.issn.1674-490X.2015.03.013
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    Objective To investigate and compare the changes of hemodynamic and the occurrence of adverse reaction of etomidate and propofol used in short time neurosurgery.Methods 50 patients undergone elective neurosurgery, whose operation time was limited to 2-3 hours, were randomly divided into etomidate group (group E, n=25) and propofol group (group P, n=25). Induction with sufentanil 0.3 μg/kg, rocuronium 0.6 mg/kg, group P with propofol 2.0 mg/kg, group E with etomidate 0.3 mg/kg. Recording the basal state (T0), beforeintubation moment (T1), after intubation (T2) and 1 min after intubation (T3), 3 min (T4), 5 min (T5), 10 min (T6), systolic blood pressure(SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), oxygen saturation (SpO2) and heart rate (HR), recording the application of vasoactive drugs, intake and output, the recovery time and extubation time and the incidence of adverse reactions were recorded. Results (1) The fluid volume, operation time, anesthesia time, postoperative recovery time after extubation were not difference in patients in the two groups. (2) In group P, in T4, T5, T6, SBP, DBP decreased significantly (P<0.05 or P<0.01). In T3 HR increased obviously (P<0.05), in T4, T5, T6, decreased (P<0.05). In group E T3, T4, HR increased significantly (P<0.05 or P<0.01). (3) The highest HR, the highest SBP and the lowest SBP, were of no statistical significance, application of vasoactive drugs in patients in the two group were 4% in group E, and 16% in group P, the difference was statistically significant (P<0.01). (4) Injection pain was significantly lower in the group E than that in group P(P<0.01). Conclusion Etomidate can be safely applied in short-time neurosurgery operation. Compared with propofol, etomidate has less influence on hemodynamic in induction and maintenance, but the postoperative restlessness, nausea, vomiting were higher.
    Clinical analysis of some related factors affecting the treatment of femoral neck fractures
    YAN Zuo
    2015, 32(3):  61-64.  DOI: 10.3969/j.issn.1674-490X.2015.03.014
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    Objective To explore some late collapse factors associated with ischemic necrosis of femoral head in affecting the treatment of patients with femoral neck fractures by applying hollowscrew fixation Methods 44 patients with femoral-neck- fracture in our hospital from February 2010 to December 2013 were selected as research subjects treated with hollow screw nail fixation. The related factors ,such as the fracture types, reset categories, the conditions of the fractures, operation time and so on were analyzed by using Logistic multivariate analysis method. Results The results indicated that related factors affecting the treatment effects were the followings; first fracture translocation , then the quality of reduction, the injury time to operation time and the reset types and etc. Conclusion The degree of fracture displacement is the most important factors affecting the prognosis of patients with femoral-neck-fracture, operation time and the fracture reduction effects have an impact on the prognosis of quality , but opening-reduction and age factor have not obvious effects on femoral head necrosis and ischemia.
    Investigation on prevalence rate of dental caries and status of related knowledge of pupils in a primary school in Baoding
    LI Jialin, LI Hefei
    2015, 32(3):  65-68.  DOI: 10.3969/j.issn.1674-490X.2015.03.015
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    Objective To investigate the prevalence rate of dental caries of pupils in Baoding and know the status of caries awareness of prevention, so as to provide feasibility suggestion for pupils’ early prevention of caries. Methods By useing the method of group sampling, 1 441 children aged from 7 to 12 in a primary school in Baoding were examined and investigated separately.Results (1)There were 977 children had caries, prevalence rate was 67.80%. Prevalence rates of urban and rural were 65.96% and 75.94% respectively and were showed significant difference between them( χ2=9.900, P=0.002). The highest and lowest rates of caries were in the age groups 6-7 (71.95%) and 10-12(61.29%) respectively. (2) In the five questions of caries prevention, scores of urban pupils were higher than rural ones, those of girls were higher than boys, there were no significant difference between three age groups. Conclusion The current rate of dental caries of pupils is high, educational institutions and parents should take some effective measures according to the different characteristics such as town and countryside, gender and age to protect children’s teeth and decrease the rate of caries.
    Effects of structural psychological intervention on the patients with malnutrition after cardiac cancer operation
    LI Jialin,LI Hefei
    2015, 32(3):  69-74.  DOI: 10.3969/j.issn.1674-490X.2015.03.016
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    Objective To evaluate the effects of structural psychological intervention on the mentality and quality of life in patients with malnutrition after the cardiac cancer operation. Methods Fifty-six patients with malnutrition after the operation of cardiac cancer were randomly divided into intervention group and control group. The 28 patients in the control group received routine admission education and health education. The others in the intervention group received 3 structural psychological intervention in addition to routine admission education and health education. The mentality and quality of life with two group patients were investigated by using SCL-90 and QLQ-C30 questionare at the time of admission and 1 month later. Results There was significant difference in mental health status for patients with malnutrition compared with the norm assessed by SCL-90 (P<0.01). After intervention, the SCL-90 scores in intervention group (except hostility) were lower than that in the control group(P<0.01). The comparison between the two groups after 1 month showed there was statistically significant differences in physical function, emotional function, sociology function, general health status ,fatigue, nausea and vomiting, insomnia, appetite loss, constipation (P<0.01). Conclusion The structural psychological intervention is able to alleviate the mental symptoms and improve their quality of life in the patients with malnutrition after the cardiac operation.
    The development of orthodontics in the three dimensional finite element method
    ZHANG Wanjun, LI Jinyuan, MA Yongping, GAO Linqing
    2015, 32(3):  75-81.  DOI: 10.3969/j.issn.1674-490X.2015.03.017
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    The action force is usually reflected during orthodontic process, so the study of orthodontic cannot be separated with the biomechanics analysis. With the development and popularization of the computer technology, the mechanical analysis method, for example, the three dimensional finite element analysis method has become more and more mature. Because its model has good geometry similarity, as well as the analysis of complex geometry is widely used in the field of biomechanics. This paper is mainly about the definition, operation steps of the three dimensional finite element analysis method, and the application and development of this method in many aspects of the orthodontics field, such as teeth body, periodontal tissue, dental implant etc. Besides, the development direction of the three dimensional finite element analysis method (3D-FEM) in orthodontic biomechanics is also introduced.
    The role of innate immune response during infection of Brucella
    GAO Wei, WANG Meng, CAO Zhiran
    2015, 32(3):  82-86.  DOI: 10.3969/j.issn.1674-490X.2015.03.018
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    Brucella is a Gram-negative, facultative intracellular bacteria, which includes Brucella. abortus(cattle), B.melitensis(goats), B.suis (swine), B.canis(dogs) and Brucella infected by marine mammals,et al. B.abortus, B.melitensis, B.suis and B.canis, et al can invade into humans and animals through a variety of ways and cause Brucellosis that is a severe zoonotic desease. The innate immune system is the first line of defensing against the infection of pathogen for our organism, which plays a key role during the infection of Brucella. This paper overviews the role of innate immune response during the infection of Brucella.
    Advances on inhibitory effects of Genistein on colon cancer cell and its mechanism
    LI Weiwei, SHI Ruiting, WU Suhuan
    2015, 32(3):  87-90.  DOI: 10.3969/j.issn.1674-490X.2015.03.019
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    Genistein is a kind of estrogen natural isoflavone compounds which exists in the leguminous and dentate plants. It is significant to the prevention and treatment of cancer with wide anticancer pharmacological activities. In this paper, we summarize the latest research progress of the effects of Genistein on cell inhibitory and its mechanism of colon cancer cell on the basis of a large number of recent references at home and abroad.
    Research advance on clinical application of Safflower
    LIU Juan, LI Jianwei, QIAO Yufeng, NIU Tianzeng, LI Minghua
    2015, 32(3):  91-94.  DOI: 10.3969/j.issn.1674-490X.2015.03.020
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    Safflower is applied in the treatment of cardiac-cerebral vascular disease, gynecological diseases and traumatic injuries because of its significant effects in blood circulation and activating collaterals. In recent years, new pharmacological actions of safflower have been reported, such as calming effect, analgesic effect, anti-inflammatory and analgesic effect, anti-tumor and hypoxia, so it is widely used in the treatment of nerve system disease, neoplastic disease, diabetes, leucoderma and so on. The authors have summarized the clinical applications and adverse effects of safflower and its preparations in order to provide some references for the correct use in the future.
    The current researching situation and thinking of Orem theory of self-care in the aged patient with stroke
    RONG Yanqin, JING Kunjuan
    2015, 32(3):  95-98.  DOI: 10.3969/j.issn.1674-490X.2015.03.021
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    Improving the quality of survival in patients with stroke has became the focus of the medical staff,because stroke is common and frequently-occurring disease threating to people’s life and health.By reviewing 31 related papers, the authors review researching method for evaluating the self-care needs and self-care ability,using in different sequela and nursing unit and so on. At the same time, the authors come up with ideas of the service, aiming at providing a theoretical basis for taking care of patient with stroke and indicating the direction for future research.
    Analysis of the clinical nursing characteristics of peptic ulcer disease in the elderly
    ZHENG Pei
    2015, 32(3):  99-101.  DOI: 10.3969/j.issn.1674-490X.2015.03.022
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    In recent years, the incidence of the aged patients with peptic ulcer is on the rise in our country. Many aspects, such as pathogenic sites, pathological characteristics, clinical symptoms, and complications have unique characteristics which are different from young and middle-aged patients in this disease. Fully understanding the clinical characteristics of the aged patients with peptic ulcer correctly and developing positive and effective nursing are significant for the health of the elderly.
    Significance of special education of acute chest pain in general practitioners training
    ZHI Xiao, WANG Yanbo, ZHANG Lanying
    2015, 32(3):  102-104.  DOI: 10.3969/j.issn.1674-490X.2015.03.023
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    “Acute chest pain” is the common symptoms in emergency department which involves in multiorgans and systems.The difficulty and the critical point of emergency treatments are making differential diagnosis rapidly and accurately. In recent years, we undertake the task of general practice training in Hebei province and train general practitioners for Shijiazhuang and surrounding counties and cities. Training for general practitioners about acute chest pain, as a special education, have improved its recognition and management significantly.
    Investigation on the reasons of medical students from the second military medical university failing to complete the extracurricular research projects
    ZHAN Xianbao, ZHANG Jingxi
    2015, 32(3):  105-107.  DOI: 10.3969/j.issn.1674-490X.2015.03.024
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    Objective The reasons of medical students failing to complete the extracurricular research projects.Methods The completion of extracurricular research projects by medical students from the year 1990 to 2015 was investigated retrospectively. The reasons of medical students failing to complete the extracurricular research projects were analyzed. Results A total of 32 medical students participated in 35 research projects led by our team, among which 23 projects were completed (65.71%). The major failure reasons of 12 uncompleted projects included: lack of enthusiasm from instructor(4, 33.33%), lack of capacity of students(3, 25.00%), lack of interest from students (2, 16.67%), lack of teamwork from students (16.67%), lack of innovation of the project (1, 8.33%). Conclusion It is desireable to improve the outcomes of the medical students’ extracurricular scientific acitivities by improving the instructor's enthusiasm and the students’ teamwork, establishing the students’ interest and innovation, and following individualized instructional strategies.