Abstract: Objective To study the effects of the increase of the dose of cisatracurium and rocuronium on the onset time and the clinical duration. Methods 120 patients ASAⅠ-Ⅱ, aged 30-55 years, scheduled for elective gynecologic surgery were randomly divided into four groups(n=30). Group A received cisatracurium 0.10 mg/kg(2×ED95). Group B received cisatracurium 0.15 mg/kg (3×ED95). Group C received cisatracurium 0.2 mg/kg(4×ED95). Group D received rocuronium 0.9 mg/kg. Neuromuscular block was monitored by a TOF Watch SX accelerograph. The onset time and the clinical duration were recorded. Results The onset times for group A, B, C and D were (226±57)s, (184±56)s, (135±45)s, (80±25)s seconds respectively. Compared with group A, B, D, there was statistically difference between group C and those groups (P<0.05). The clinical effective time were (33±5)min, (41±8)min, (53±8)min, (42±11)min among group A, B, D, respectively, compared with group A, B, D, there were signiifcant difference between group C and those groups (P<0.05).Conclusion Increasing dose could signiifcantly shorten cisatracurium onset time of intubation. But compared with rocuronium, clinical duration is longer. Cisatracurium is not suitable for short surgical operation. The clinical effects of rocuronium time variability controllability, cisatracurium is better than that of rocuronium.

Key words: Cisatracurium, Rocuronium, onset time, clinical duration