The significance of PI3K/Akt/mTOR pathway and autophagy in the proliferation of synovial cells in rheumatoid arthritis

doi:10.3969/j.issn.1674-490X.2013.05.019

Abstract

Abstract: Autophagy is a crucial self-saving behavior of mammalian cells in growth and development of organism. Autophagy can keep cells survival via eliminating the metaprotein and necrosis substance then rebuilding the structure of cells in the situation of stress, but it can also lead to typeⅡapoptosis if it occur unduly. PI3K/Akt/mTOR , which involved in multiple physiological and pathological process, is an important signal pathway existing in various cells. The products of activated PI3K/Akt/mTOR pathway will inhibit the cell autophagy. In the early stage of rheumatoid arthritis (RA), the rheumatoid arthritis synovial ifbroblasts (RASF) initiate autophagy in several ways, in order to maintaining the homeostasis of RASF and cell proliferation. With the progress of RA, the activating platelet particles (such as PDGFRα) will suppress autophagy via activating the PI3K/Akt/mTOR signal pathway, thereby prevent RASF from typeⅡapoptosis induced by excessive autophagy, lead to RASF’s continuing proliferation and aggravate the pathogenetic condition. The purpose of this article is to summarize the signiifcance of PI3K/Akt/mTOR signal pathway and autophagy in the persistently proliferation of RASF, discuss the pathogenesis of RA and ifnd new therapeutic targets.

Key words: autophagy, typeⅡapoptosis, PI3K/Akt/mTOR, RASF, activating platelet particles

CLC Number:

MENG Ming,LIANG Hongge,FANG Hao,ZHOU Lei,FENG Jianyong,DONG Yang,YAN Zhen,CHEN Dongzhi. The significance of PI3K/Akt/mTOR pathway and autophagy in the proliferation of synovial cells in rheumatoid arthritis[J]. Medical Reserch and Education, 2013, 30(5): 69-74.

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