Abstract: Objective To study the effects of small dose aspirin on preeclampsia and its effect on coagulation function. Methods From September 2016 to August 2017, 90 pregnant women with preeclampsia were selected. According to the random number table method, the participants were randomly divided into observation group and control group(45 cases each)according to a 1∶1 ratio. The patients in the control group were treated with the basic intervention combined with traditional prevention methods, the patients in the observation group were given added low-dose aspirin. Two groups of pregnant women before and after prevention of symptoms, blood pressure, blood coagulation levels ［D-dimer(D-D), prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), thrombin Time(TT)］, endothelin(ET), were observed and compared. Results The observation group had a clinical control rate of 55.56% and a total effective rate of 95.56%, which was significantly higher than that of the control group(40.00%, 77.78%, P<0.05). After prevention, systolic blood pressure and diastolic blood pressure decreased in both study groups before and after treatment, and systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group(P<0.05).After prevention, the levels of D-D, FIB, TT and ET in the two study groups decreased compared with those before the prevention, while the levels of PT, APTT and PT, APTT in the observation group decreased more than those in the control group but higher than that of the control group, the difference was statistically significant(P<0.05). The comparison of coagulation indicators and ET difference before and after treatment in two groups showed statistical significance(P<0.05). Conclusion Low-dose aspirin is effective in curing preeclampsia, prolonging gestational age, enriching and enriching the mechanism of preeclampsia, and providing a reference for clinical prevention.

Key words: preeclampsia, aspirin, small dose, coagulation