延时低温对急性肺损伤早期炎症反应和肺水的影响

doi:10.3969/j.issn.1674-490X.2010.02.007

医学研究与教育 ›› 2010, Vol. 27 ›› Issue (2): 20-25.DOI: 10.3969/j.issn.1674-490X.2010.02.007

延时低温对急性肺损伤早期炎症反应和肺水的影响

梁璐¹,曹国辉¹,王新平¹,彭广军¹,徐军²,王仲²,于学忠²,马遂²

1.河北大学附属医院,急诊科,河北,保定,071000
2.北京协和医学院,北京协和医院急诊科,北京,100730

收稿日期:2016-10-09 修回日期:2016-10-09 出版日期:2010-04-25 发布日期:2010-04-25

Effects of delayed hypothermia on earlier inflammatory reaction and lung water of acute lung injury induced by intestinal ischemia-reperfusion in rabbits

Received:2016-10-09 Revised:2016-10-09 Online:2010-04-25 Published:2010-04-25

摘要/Abstract

摘要： 目的研究延迟开始的低温对肠缺血再灌注所致急性肺损伤早期炎症反应和肺水的影响. 方法新西兰大白兔60只(10只/组),随机分为空白对照组(肛温37～38 ℃,假手术组)、缺血对照组(肛温37～38 ℃)、浅低温组(肛温32～35 ℃)、中低温组(肛温28～31.9 ℃)、延迟浅低温组(直肠目标温度32～35 ℃)、延迟中低温组(直肠目标温度28～31.9 ℃).实验组采用完全夹闭肠系膜上动脉(super mesenteric artery,SMA)1 h,开放后再灌注的方法制备肠缺血再灌注(Intestine Ischemia Reperfusion,IIR)致急性肺损伤(acute lung injury,ALI)模型.采用体表降温的方法控制实验动物体温.再灌注6 h后测定支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid,BALF)TNF-α、IL-1β、IL-6、IL-10水平;再灌注6 h后处死动物取肺组织标本,测定肺组织湿/干比值. 结果和空白对照组比较,实验组BALF中TNF、IL-1、IL-6、IL-10水平升高,肺组织肺水增加.在实施低温治疗后,同缺血对照组相比,上述肺损伤的表现得到了改善,延迟开始的低温治疗也有一定的效果. 结论 浅低温和中低温可以有效改善IIR导致ALI动物模型的早期炎症反应,减轻肺组织损伤的程度;延迟开始的低温也有一定的效果.

关键词: 肠缺血再灌注, 急性肺损伤, 浅低温, 中低温

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梁璐,曹国辉,王新平,彭广军,徐军,王仲,于学忠,马遂. 延时低温对急性肺损伤早期炎症反应和肺水的影响[J]. 医学研究与教育, 2010, 27(2): 20-25.

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延时低温对急性肺损伤早期炎症反应和肺水的影响

Effects of delayed hypothermia on earlier inflammatory reaction and lung water of acute lung injury induced by intestinal ischemia-reperfusion in rabbits

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