CysC和Hcy在糖尿病肾病中的应用

doi:10.3969/j.issn.1674-490X.2013.05.009

医学研究与教育 ›› 2013, Vol. 30 ›› Issue (5): 32-34,45.DOI: 10.3969/j.issn.1674-490X.2013.05.009

CysC和Hcy在糖尿病肾病中的应用

王建国,王淑仙,梁淑新,李铁民

河北大学附属医院,河北保定,071000

收稿日期:2016-10-10 修回日期:2016-10-10 出版日期:2013-10-25 发布日期:2013-10-25

Clinical application of CysC and Hcy detection in diabetic nephropathy

WANG Jianguo,WANG Shuxian,LIANG Shuxin,LI Tiemin

Received:2016-10-10 Revised:2016-10-10 Online:2013-10-25 Published:2013-10-25

摘要/Abstract

摘要： 目的：探讨胱抑素C（CysC）和同型半胱氨酸（Hcy）联合检测在糖尿病肾病（DN）中的临床应用价值。方法根据24尿白蛋白排泄率将142例糖尿病（DM）患者分为单纯糖尿病组（SDM组）、早期糖尿病肾病组（EDN组）、临床糖尿病肾病组（CDN组），分别检测各组患者血清中CysC和Hcy。结果 CysC浓度在4组之间经方差分析，其差异具有统计学意义（F=180.273，P<0.05）；Hcy浓度在4组之间经方差分析，其差异具有统计学意义（F=117.064，P<0.05）。CysC和Hcy的浓度在SDM组与正常对照组（NC组）之间进行两两比较时，经统计学分析其差异无统计学意义（P>0.05）；而EDN组和CDN组分别与NC组进行两两比较时，经统计学分析其差异均有统计学意义（P<0.05）；CysC和Hcy在SDM、EDN、CDN 3组间的浓度呈逐渐增高趋势，且3组之间进行两两比较时，经统计学分析，其差异均有统计学意义（P<0.05）。结论CysC和Hcy联合检测可作为DN的早期诊断指标，同时也可作为DN病情的监测指标。

关键词: 胱抑素C, 同型半胱氨酸, 糖尿病肾病

Abstract: Objective To study the value of clinical application of detection of serum cystatin C(Cysc), hemocysteine(Hcy) in judgement of renal damage of patients with early diabetic nephropathy(DN). Methods According to 24 h urinary albumin excretion rate(UAER), 142 patients with diabetes mellitus(DM) were divided into three groups, including simple diabetes mellitus(SDM), early diabetic nephropathy(EDN) and clinical diabetic nephropathy(CDN) group. Results There were significant differences among the four groups considering the concentration of CysC and Hcy(F=180.273, P<0.05. F=117.064, P<0.05). There were no signiifcant differences between SDM and NC groups connecting the concentration of CysC and Hcy(P>0.05). There were signiifcant differences between EDN, CDN and NC groups connecting the concentration of CysC and Hcy(P<0.05). There was an increased trend in the concentration of CysC and Hcy in the groups of SDM, EDN and CDN. There were signiifcant differences between the groups (P<0.05). Conclusion The combined detection of CysC and Hcy were sensitve indicators in judgement of early renal damage of DN patients, At the same time, they could be used as a monitoring index in patients with DN.

Key words: cystatin C, homocysteine, diabetic nephropathy

中图分类号:

R446

王建国,王淑仙,梁淑新,李铁民. CysC和Hcy在糖尿病肾病中的应用[J]. 医学研究与教育, 2013, 30(5): 32-34,45.

WANG Jianguo,WANG Shuxian,LIANG Shuxin,LI Tiemin. Clinical application of CysC and Hcy detection in diabetic nephropathy[J]. Medical Reserch and Education, 2013, 30(5): 32-34,45.

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CysC和Hcy在糖尿病肾病中的应用

Clinical application of CysC and Hcy detection in diabetic nephropathy

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