医学研究与教育 ›› 2015, Vol. 32 ›› Issue (6): 21-24.DOI: 10.3969/j.issn.1674-490X.2015.06.004

• 基础研究 • 上一篇    下一篇

丹参多酚对重症急性胰腺炎大鼠胰腺微血管通透性的影响

李田阳1,韩丽2,贾宁2,李雅静2,田媛2   

  1. 河北省唐县人民医院麻醉科,河北 唐县 072350
  • 出版日期:2015-12-25 发布日期:2015-12-25
  • 通讯作者: 田媛(1980—),女,河北保定人,主治医师,硕士,主要从事急性胰腺炎的诊治。 E-mail: tianyuan19800524@163.com
  • 作者简介:李田阳(1995—),男,河北保定人。E-mail: 1146252287@qq.com

Effects of Salvia miltiorrhiza polyphenols on the microvascular permeability of pancreas in rats with severe acute pancreatitis

LI Tianyang1 , HAN li2 , JIA Ning2 , LI Yajing2, TIAN Yuan2   

  1. 1. College of Clinical Medicine, Hebei University, Baoding 071000, China; 2. Department of Gastroenterology, Affiliated Hospital of Hebei University, Baoding 071000, China
  • Online:2015-12-25 Published:2015-12-25

摘要: 目的 探讨丹参多酚对重症急性胰腺炎大鼠胰腺微血管通透性的影响。方法 重症急性胰腺炎大鼠预防性尾静脉给予 丹参多酚,通过伊文氏兰法检测大鼠胰腺微循环通透性改变。结论 与空白对照组比较,SAP 模型组造模 6 h 后,胰腺微 血管通透性明显增强;与 SAP 模型组比较,丹参多酚组胰腺微血管通透性明显降低,组间差异有统计学意义(P<0.05)。 结论 丹参多酚是改善重症急性胰腺炎大鼠胰腺微血管通透性的有效方法。

关键词: 丹参多酚, 重症急性胰腺炎, 微血管通透性

Abstract: Objective To investigate the effects of Salvia miltiorrhiza polyphenols on the microvascular permeability of pancreas in rats with severe acute pancreatitis. Methods The rats with severe acute pancreatitis were given Salvia miltiorrhiza polyphenols through caudal vein, the pancreatic microvascular permeability was detected by using the Evans blue method.Results Compared with the control group, the pancreatic microvascular permeability was significantly enhanced in SAP model group; compared with the SAP model group, the pancreatic microvascular permeability was decreased significantly in Salvia miltiorrhiza polyphenols group, the differences between the two groups were significant. Conclusion Salvia miltiorrhiza polyphenols is an effective method to improve the microvascular permeability of the rats with severe acute pancreatitis.

Key words: Salvia miltiorrhiza polyphenols, severe acute pancreatitis, microvascular permeability

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