小剂量阿司匹林治疗子痫前期的疗效及对凝血功能的影响

doi:10.3969/j.issn.1674-490X.2019.04.002

医学研究与教育 ›› 2019, Vol. 36 ›› Issue (4): 5-9.DOI: 10.3969/j.issn.1674-490X.2019.04.002

小剂量阿司匹林治疗子痫前期的疗效及对凝血功能的影响

石清蒲,李力,汪丛敏

保定市第一中心医院产科, 河北保定 071000

收稿日期:2018-10-15 出版日期:2019-08-25 发布日期:2019-08-25
作者简介:石清蒲(1980—),女,河北高阳人,副主任医师,硕士,主要从事产科孕产期保健、妊娠合并症的诊治,产科危重病人抢救的研究与处理。 E-mail: 1123879329@qq.com
基金资助:
河北省重点研发计划项目(152777187)

Received:2018-10-15 Online:2019-08-25 Published:2019-08-25

摘要/Abstract

摘要： 目的研究小剂量阿司匹林治疗子痫前期的疗效及对凝血功能的影响。方法选取2016年9月至2017年8月子痫前期孕妇90例,参考随机数字表法,按照1∶1比例将纳入者随机分为观察组和对照组(各45例)。对照组采取基础干预联合传统治疗方法,观察组加用联合小剂量阿司匹林,观察和比较2组孕妇治疗前后自觉症状、血压、凝血指标水平［D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)］、内皮素(ET)。结果观察组显效率55.56%、总有效率95.56%,高于对照组的40.00%、77.78%,差异有统计学意义(P<0.05)。治疗后,2组研究对象收缩压、舒张压均较治疗前下降,且观察组收缩压、舒张压低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组研究对象D-D、FIB、TT、ET均较治疗前下降,PT、APTT较治疗前升高,且观察组D-D、FIB、TT、ET水平下降优于对照组,PT、APTT水平升高优于对照组,2组研究对象凝血指标及ET治疗前后差值的比较,差异均有统计学意义(P<0.05)。结论小剂量阿司匹林治疗子痫前期效果显著,利于延长孕周,丰富和充实了子痫前期发生机制学说。

关键词: 子痫前期, 阿司匹林, 小剂量, 凝血

Abstract: Objective To study the effects of small dose aspirin on preeclampsia and its effect on coagulation function. Methods From September 2016 to August 2017, 90 pregnant women with preeclampsia were selected. According to the random number table method, the participants were randomly divided into observation group and control group(45 cases each)according to a 1∶1 ratio. The patients in the control group were treated with the basic intervention combined with traditional prevention methods, the patients in the observation group were given added low-dose aspirin. Two groups of pregnant women before and after prevention of symptoms, blood pressure, blood coagulation levels ［D-dimer(D-D), prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), thrombin Time(TT)］, endothelin(ET), were observed and compared. Results The observation group had a clinical control rate of 55.56% and a total effective rate of 95.56%, which was significantly higher than that of the control group(40.00%, 77.78%, P<0.05). After prevention, systolic blood pressure and diastolic blood pressure decreased in both study groups before and after treatment, and systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group(P<0.05).After prevention, the levels of D-D, FIB, TT and ET in the two study groups decreased compared with those before the prevention, while the levels of PT, APTT and PT, APTT in the observation group decreased more than those in the control group but higher than that of the control group, the difference was statistically significant(P<0.05). The comparison of coagulation indicators and ET difference before and after treatment in two groups showed statistical significance(P<0.05). Conclusion Low-dose aspirin is effective in curing preeclampsia, prolonging gestational age, enriching and enriching the mechanism of preeclampsia, and providing a reference for clinical prevention.

Key words: preeclampsia, aspirin, small dose, coagulation

中图分类号:

石清蒲,李力,汪丛敏. 小剂量阿司匹林治疗子痫前期的疗效及对凝血功能的影响[J]. 医学研究与教育, 2019, 36(4): 5-9.

[1]	赵峰,张红茹,丁乾,徐洋涛,刘倩. 启阳胶囊联合小剂量5-磷酸二酯酶抑制剂治疗2型糖尿病性勃起功能障碍[J]. 医学研究与教育, 2020, 37(3): 28-31.
[2]	马腾腾,霍丽娇,柏金秀,魏继红,张磊. 内皮微粒与肾脏疾病研究进展[J]. 医学研究与教育, 2019, 36(1): 17-23.
[3]	刘宏祥,赵永辰,史曼,齐姣,刘一,王颖. 双联抗血小板聚集在TIA-ABCD3-I评分中的应用[J]. 医学研究与教育, 2013, 30(3): 33-36.
[4]	梁义娟,刘金,薛会灵,张旭静,赵丹,吕丽娟. 子痫前期患者胎盘组织中Endoglin的表达及意义[J]. 医学研究与教育, 2012, 29(4): 17-19.

小剂量阿司匹林治疗子痫前期的疗效及对凝血功能的影响

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价