中性粒细胞与淋巴细胞比值和非瓣膜性房颤患者左房血栓之间的关系研究

doi:10.3969/j.issn.1674-490X.2014.04.009

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (4): 34-37.DOI: 10.3969/j.issn.1674-490X.2014.04.009

中性粒细胞与淋巴细胞比值和非瓣膜性房颤患者左房血栓之间的关系研究

安艳晓¹,柳克晔²,王洋²,罗志强²,韩喆²,刘福林²

1.河北大学,河北保定,071000
2.河北大学附属医院,河北保定,071000

收稿日期:2016-09-29 修回日期:2016-09-29 出版日期:2014-08-25 发布日期:2014-08-25

Association of neutrophil-lymphocyte ratio with left atrial thrombus in patients with nonvalvular atrial ifbrillation

AN Yanxiao¹,LIU Keye²,WANG Yang²,LUO Zhiqiang²,HAN Zhe²,LIU Fulin²

Received:2016-09-29 Revised:2016-09-29 Online:2014-08-25 Published:2014-08-25

摘要/Abstract

摘要： 目的：中性粒细胞与淋巴细胞比值（NLR）与心血管病人较差的预后有关。旨在对有左房血栓（LAT）的非瓣膜性房颤（NVAF）患者和无左房血栓的非瓣膜性房颤患者之间的NLR进行比较。方法选取河北大学附属医院155名NVAF病人，使用经胸超声心动图（TTE）检测LAT。NLR是中性粒细胞计数与淋巴细胞计数的比值。结果155名病人中有16名（10.3%）病人存在左房血栓，左房血栓组平均NLR明显高于无左房血栓组（2.8±1.2，2.0±1.1，P=0.023）。经多因素分析，NLR是NVAF病人左房血栓的独立危险因素（OR1.78,95%CI1.93~4.24，P<0.001）。结论NLR，新发现的炎症指标，与NVAF病人左房血栓存在独立相关。

关键词: 房颤, 左房血栓, 炎症, 中性粒细胞与淋巴细胞比值

Abstract: Objective To compare NLR among patients with nonvalvular atrial ifbrillation (AF) with or without left atrial (la) thrombus. Methods 155 patients with nonvalvular AF undergone transthoracic echocardiography (TTE) were selected to assess the presence of la thrombus. Baseline NLR was measured by dividing neutrophil count to lymphocyte count. Results Left atrial thrombus was detected in 16(10.3%) of 155 patients. Mean NLR (2.8 ± 1.2, 2.0 ± 1.1, P=0.023) was significantly higher among patients with la thrombus compared to patients without la thrombus. On multivariate analysis, NLR (odds ratio 1.78, 95%conifdence interval 1.93-4.24, P<0.001) was an independent risk factor for the presence of la thrombus in patients with nonvalvular AF. Conclusion Neutrophil-lymphocyte ratio, an emerging marker of inlfammation, is independently associated with the presence of la thrombus in patients with nonvalvular AF.

Key words: atrial ifbrillation, left atrial thrombus, inlfammation, neutrophil-lymphocyte ratio

中图分类号:

安艳晓,柳克晔,王洋,罗志强,韩喆,刘福林. 中性粒细胞与淋巴细胞比值和非瓣膜性房颤患者左房血栓之间的关系研究[J]. 医学研究与教育, 2014, 31(4): 34-37.

AN Yanxiao,LIU Keye,WANG Yang,LUO Zhiqiang,HAN Zhe,LIU Fulin. Association of neutrophil-lymphocyte ratio with left atrial thrombus in patients with nonvalvular atrial ifbrillation[J]. Medical Reserch and Education, 2014, 31(4): 34-37.

参考文献

[1] 周自强, 胡大一, 陈捷, 张仁汉, 李奎宝, 赵秀丽. 中国心房颤动现状的流行病学研究 [J]. 中华内科杂志 2004.doi:10.3760/j.issn:0578-1426.2004.07.005
[2] Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. [J]. JAMA: the Journal of the American Medical Association 2001, 18(18).
[3] Watson T, Shantsila E, Lip GY. Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited. [J]. The Lancet 2009, 9658(9658).
[4] Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. [J]. JAMA: the Journal of the American Medical Association 2001, 22(22).
[5] 封盼攀, 贾锋鹏, 顾俊, 高凌云, 何泉, 吕斐. CHA2DS2-VASc评分对非瓣膜病心房颤动患者射频消融前左房血栓的风险评估 [J]. 第三军医大学学报 2013.
[6] Neutrophil to lymphocyte ratio and cardiovascular diseases: A review [J]. Expert review of cardiovascular therapy 2013, 1(1).
[7] Vardas PE, Agladze V, Aliot E, Balabanski T, Blomstrom Lundqvist C, Capucci A, Crijns H, Dahlof B, Folliguet T, Glikson M, Goethals M, Gulba DC, Ho SY, Klautz RJ, Kose S, McMurray J, Perrone Filardi P, Raatikainen P, Salvador MJ, Schalij MJ, Shpektor A, Sousa J, Stepinska J, Uuetoa H, Zamorano JL, Zupan I. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). [J]. Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2010, 10(10).
[8] Gregory Y H Lip. Can we predict stroke in atrial fibrillation? [J]. Clinical cardiology 2012, Suppl.1(Suppl.1).
[9] Erta?, G., S?nmez, O., Turfan, M., Kul, ?., Erdo?an, E., Tasal, A., Bacaksiz, A., Vatankulu, M.A., Altinta?, ?., Uyarel, H., G?ktekin, ?.. Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation [J]. Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology 2013, 1/2(1/2).
[10] Klein AL. Relation of C-reactive protein correlates with risk of thromboembolism in patients with atrial fibrillation. [J]. The American Journal of Cardiology 2004, 6(6).
[11] Marin F, Corral J, Roldan V, Gonzalez Conejero R, Del Rey ML, Sogorb F, Lip GY, Vicente V. Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation. [J]. Journal of Molecular and Cellular Cardiology 2004, 3(3).

[1]	罗发梦,刘蓉,林威娜,张海燕,陶德智. 炎症性肠病患者延续性护理体验和需求的质性研究[J]. 医学研究与教育, 2023, 40(5): 66-71.
[2]	周向阳,吴迪,米甜,李文娟. 瘦素的生物学作用及其相关机制研究进展[J]. 医学研究与教育, 2023, 40(4): 1-10.
[3]	张静波, 史坚, 杨静云, 冉继鹏, 刘子腾, 张莎莎. 抗核抗体与主动脉壁间血肿发生的相关性分析[J]. 医学研究与教育, 2022, 39(5): 19-24.
[4]	罗发梦,刘蓉,张海燕. 炎症性肠病患者的药物管理研究进展[J]. 医学研究与教育, 2022, 39(2): 66-71.
[5]	朱健平,李运曼. Nrf2在缺血性脑损伤中的关键性作用[J]. 医学研究与教育, 2022, 39(2): 1-9.
[6]	周程艳,李倩,梁宇璇,国洪宾,赵盈秋. 两种动脉粥样硬化模型制备方法的比较[J]. 医学研究与教育, 2021, 38(1): 1-11.
[7]	柴素伟. 腹腔镜结直肠癌NOSES疗效分析以及对氧化应激、炎性反应的影响[J]. 医学研究与教育, 2020, 37(5): 31-35.
[8]	马莹莹,傅继华. 脂质、炎症在动脉粥样硬化发展机制中的研究进展[J]. 医学研究与教育, 2019, 36(2): 1-7.
[9]	马腾腾,霍丽娇,柏金秀,魏继红,张磊. 内皮微粒与肾脏疾病研究进展[J]. 医学研究与教育, 2019, 36(1): 17-23.
[10]	邱燕英,赵勃,方伟蓉,李运曼. Toll样受体与脑缺血的关系及相关药物研究进展[J]. 医学研究与教育, 2019, 36(1): 6-12.
[11]	赵会娟,尹晓琳,王园园,刘慧芳,孟明,陈冬志. iNKT细胞在肥胖脂肪组织慢性炎症发生中的作用[J]. 医学研究与教育, 2018, 35(1): 19-24.
[12]	卢志茹,李力. 剖宫产术后全身炎症反应综合征4例临床分析[J]. 医学研究与教育, 2016, 33(3): 73-76.
[13]	张兰芳，陈彦霞，赵淑君，解俊敏，陈美鹤，张进尊，韩昆鹏. 厄贝沙坦联合胺碘酮对阵发性房颤患者转律及窦性心律维持的临床研究[J]. 医学研究与教育, 2014, 31(6): 41-45.
[14]	李向农，王丽萍，崔英凯. 经食道超声对射频消融术前房颤患者左房及左心耳血栓的诊断价值[J]. 医学研究与教育, 2014, 31(6): 21-23.
[15]	侯英健,于哲,步玉辉,韩艳梅. 血红素氧合酶-1介导匹伐他汀对大鼠肝脏缺血再灌注损伤的保护作用[J]. 医学研究与教育, 2013, 30(1): 9-14.

中性粒细胞与淋巴细胞比值和非瓣膜性房颤患者左房血栓之间的关系研究

Association of neutrophil-lymphocyte ratio with left atrial thrombus in patients with nonvalvular atrial ifbrillation

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价