钙通道阻滞剂对神经损伤后瘢痕处血管分布的影响

doi:10.3969/j.issn.1674-490X.2015.01.007

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (1): 31-35.DOI: 10.3969/j.issn.1674-490X.2015.01.007

钙通道阻滞剂对神经损伤后瘢痕处血管分布的影响

刘冲¹，刘晓峰²，陈涛平²，王云飞²，任宝²，郭召²，薛金伟² ，刘双立³

1. 河北大学，河北保定 071000；2. 河北大学附属医院，河北保定 071000；3. 中国人民解放军第 252 医院，河北保定 071000

出版日期:2015-02-25 发布日期:2015-02-25
通讯作者: 薛金伟（1978—），男，河北保定人，副主任医师，博士，研究生导师，主要从事周围神经损伤临床与基础研究。E-mail: xuexueisen@sohu.com
作者简介:刘冲（1986—），男，河北定州人，在读硕士，主要从事周围神经损伤临床与基础研究。E-mail: 478522677@qq.com

Effects of calcium channel blockers on the distribution of blood vessels around the scar after nerve injury

LIU Chong¹, LIU Xiaofeng², CHEN Taoping², WANG Yunfei², REN Bao², GUO Hao², XUE Jinwei², LIU Shuangli³

1. Hebei University, Baoding 071000, China; 2. Affiliated Hospital of Hebei University, Baoding 071000, China; 3. No. 252 Hospital of PLA, Baoding 071000, China

Online:2015-02-25 Published:2015-02-25

摘要/Abstract

摘要： 目的探讨钙通道阻滞剂对大鼠坐骨神经损伤后瘢痕处血管分布的实验研究。方法选用SD大鼠96 只，随机4 组，每组 24 只，制作大鼠坐骨神经损伤模型，实验组及对照组每天分别给予腹腔注射维拉帕米和生理盐水（4 mg/kg），分别于术后第4、8周进行免疫组化染色及血管灌注，观察损伤后瘢痕处血管分布情况。结果术后4、8周实验组瘢痕处血管数量多、密度高，血管分布较均匀，血管走形较规律。对照组血管数量少，密度低，血管分布不均，血管走形紊乱。结论钙通道阻滞剂能够改变损伤处血管分布状况，改善损伤处神经组织的血液供应。

关键词: 钙通道阻滞剂, 神经瘢痕, 坐骨神经损伤, 神经再生, 血管构筑

Abstract: Objective To investigate the correlation between the calcium channel blockers on the distribution of blood vessels scar after sciatic nerve injury in rats. Methods 96 SD rats were divided into 4 group at random, 24 rats in each group. The experimental rats were made sciatic nerve injury model, the experimental group and control group were given respectively a intraperitoneal injection of verapamil and physiological saline(4 mg/kg), in 4, 8 weeks after surgery immunohistochemical staining and vascular perfusion were conducted to observe the scar after injury of vascular distribution. Results In 4, 8 weeks after surgery, the blood vessel numbers were increased and the density of the nerve lesions became higher, the vascular distributions were more uniform in the rats of the experimental group. However, the results of the controls indicated that the blood vessels numbers were decreased, the density of the nerve lesions became lower, the vascular distributions were in the state of disorder. Conclusion Calcium channel blockers can be used to reduce the formation of collagen fibers to soften the scars, and thus improve the distribution of the lesions of blood vessels and promote the blood supply of nerve tissue damage, and make the damaged nerve bundle membrane and blood capillary hyperplasia of outer membrane recovered to accelerate the nerve regeneration and speed up the recovery of neural functions.

Key words: calcium channel blockers, nerve scar, sciatic nerve injury, nerve regeneration, angioarchitecture

中图分类号:

R361

刘冲，刘晓峰，陈涛平，王云飞，任宝，郭召,薛金伟，刘双立. 钙通道阻滞剂对神经损伤后瘢痕处血管分布的影响[J]. 医学研究与教育, 2015, 32(1): 31-35.

LIU Chong, LIU Xiaofeng, CHEN Taoping, WANG Yunfei, REN Bao, GUO Zhao, XUE Jinwei, LIU Shuangli. Effects of calcium channel blockers on the distribution of blood vessels around the scar after nerve injury[J]. Medical Reserch and Education, 2015, 32(1): 31-35.

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钙通道阻滞剂对神经损伤后瘢痕处血管分布的影响

Effects of calcium channel blockers on the distribution of blood vessels around the scar after nerve injury

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